Primary neuroendocrine carcinoma of male breast: A cytologically diagnosed rare entity

Lingappa, Hemalatha Anthanahalli; Indushekar, Varna; Chamarthy, Neelima P; Soni, Abha

doi:10.4103/0970-9371.138685

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…Secondly, these rare cases of NE Carcinoma will be mainly metastasis from other primary sites (lungs and GIT). Primary NE Carcinoma, male breast in an extremely rare malignancy described in literature with only a handful of reports [4,5]. According to 2003 World health organization (WHO) classification, mammary NE carcinoma are defined as carcinomas with more than 50% expression of NE markers in tumour cells [6].…”

Section: Discussionmentioning

confidence: 99%

Primary Neuroendocrine Carcinoma of the Male Breast: a Rare Case Report

Sharma

2017

JOJNHC

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Section: Discussionmentioning

confidence: 99%

Primary Neuroendocrine Carcinoma of the Male Breast: a Rare Case Report

Sharma

2017

JOJNHC

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“…The contralateral breast, haematological malignancies, melanomas, carcinomas and sarcomas are the primary sites for the majority of breast metastases [3][4][5][6]. Most cases have been reported in female patients, while male breast metastases seem to be very infrequent [7][8][9][10]. Bilateral metastases to the breast are even more uncommon, with only very few reported in the literature [11].…”

Section: Introductionmentioning

confidence: 99%

The rare entity of bilateral and unilateral neuroendocrine metastases to the breast: a case series and literature review

Zagami

Kandaraki

Renne

et al. 2020

ecancer

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Introduction Primary neuroendocrine neoplasms (NENs) in the breast are very rare. Until 2011, the prevalence was 0.1% of all breast lesions and 1% of all NENs, whereas metastatic breast NENs represent 1%–2% of all breast tumours. However, it seems that over the last 5 years the diagnostic frequency of breast NENs has increased, probably for more alert specialists and advanced diagnostic tools, leading to a prevalence of 2%–5% of diagnosed breast cancers, mostly in the elderly population. Breast metastases from extramammary malignancies are uncommon and bilateral ones are even more uncommon, with few reported in the literature. We describe four clinical settings of breast metastases from different NENs and the multidisciplinary approach for diagnosis and treatment. Methods Four patients were found to have NEN primaries metastasised to the breast. A literature review was conducted to identify similar cases and characterise breast metastases from neuroendocrinal tumors (NETs). Results Two patients presented with bilateral breast metastases (one with well-differentiated panNET and another with atypical lung carcinoid) and two had unilateral (one with moderately differentiated lung NET and one with atypical lung carcinoid). There are about 13 cases of NEN breast metastases reported in the English literature. The ileum is the most common primary site, followed by the appendix, duodenum, pancreas and lung. Conclusion Breast lesions from extramammary primary often pose a diagnostic challenge, since a breast nodule can be the first and often the only presentation of the disease. However, differentiating between primary and secondary NEN breast lesions is essential, owing to different clinical management and prognosis.

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Primary neuroendocrine carcinoma of the breast: A rare presentation and review of the literature

Salemis¹

2020

IRDR

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neuroendocrine, carcinoma, breastPrimary neuroendocrine carcinoma of the breast (NEBC) is a very rare occurrence accounting for less than 0.1% of all breast cancers. Typically, the tumor presents with ER-and PgR-positive and HER-2-negative status. Despite its luminal type, NEBC is associated with a more aggressive clinical course and poorer prognosis compared to the other types of invasive breast cancer. Clinical and radiological findings are nonspecific. The most common clinical manifestation is a palpable mass whereas in mammography the tumor most commonly appears as a round or oval mass without spiculated margins. Herein, a very rare case of NEBC is described in an asymptomatic patient who presented with an area of architectural distortion and the presence of microcalcifications that was incidentally detected on a screening mammography. A review of the literature has also been conducted. The diagnosis of NEBC requires a thorough investigation to exclude the possibility of a metastatic neuroendocrine tumor from another site because the two entities require different treatment approaches. Due to the rarity of the disease, the optimal therapeutic approach has not been clearly defined. Surgical resection is the mainstay of treatment. Further research is needed to better understand the molecular characteristics of NEBC and identify novel targeted therapies.

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Primary neuroendocrine carcinoma of male breast: A cytologically diagnosed rare entity

Cited by 3 publications

References 4 publications

Primary Neuroendocrine Carcinoma of the Male Breast: a Rare Case Report

Primary Neuroendocrine Carcinoma of the Male Breast: a Rare Case Report

The rare entity of bilateral and unilateral neuroendocrine metastases to the breast: a case series and literature review

Primary neuroendocrine carcinoma of the breast: A rare presentation and review of the literature

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