2014
DOI: 10.1590/s0100-39842014000200017
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Primary neuroendocrine breast carcinoma: a case report and literature review

Abstract: The authors present a case of a neuroendocrine carcinoma in an asymptomatic 75-year-old woman, detected in routine breast screening. The lesion was visible at mammography as a well circumscribed, medium density nodule, with no associated microcalcifications, and at ultrasonography as a hypoechoic nodule, with irregular shape and ill-defined margins. Magnetic resonance imaging revealed findings consistent with malignancy.

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Cited by 16 publications
(17 citation statements)
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“…Recent studies conducted in Brazil have highlighted the importance of imaging examinations, especially mammography, to improving the diagnosis of breast cancer (28-34) .…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies conducted in Brazil have highlighted the importance of imaging examinations, especially mammography, to improving the diagnosis of breast cancer (28-34) .…”
Section: Discussionmentioning
confidence: 99%
“…NEBC appears hypodense on mammography, as round or irregularly shaped masses with variable margins either speculated, indistinct, circumscribed, or obscured [14]. On ultrasonography, such tumors may present as either morphologically irregular solid lesions or lesions with a cystic component, with ill defined margins and increased vascularization [11]. In the present report, the tumor had speculated margins.…”
Section: Discussionmentioning
confidence: 44%
“…The 2003 World Health Organization (WHO) histologic classification of tumors of the breast and female genital organs defined NECB as breast carcinoma with more than 50% of the cell population expressing these neuroendocrine markers. Furthermore, the diagnosis of primary neuroendocrine carcinoma of the breast can be established when either an in situ component is found or extramammary sites are excluded [ 4 5 ]. In 2012, the WHO histologic classification was upgraded and these tumors were divided into three subtypes: neuroendocrine carcinoma, well-differentiated; neuroendocrine carcinoma, poorly-differentiated/small cell carcinoma; and invasive breast carcinoma with neuroendocrine differentiation [ 6 ].…”
Section: Introductionmentioning
confidence: 99%