Primary neuroblastoma: a rare cause of a retropharyngeal mass in a neonate

Jonas, Nico; Thandar, Mohammed; Pitcher, R; Fagan, Johannes J.

doi:10.1017/s0022215106006682

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Although there were some cases reported before the 1990s, treatment modalities varied widely, even for the same stage of disease, and may have been related to proximity to vital structures which may have made complete surgical excision difficult. There have been three approaches described for surgical treatment for retropharyngeal NB; transoral [1], transcervical [14], and transhyoidpharyngotomy [4]. In our case, we performed a tracheostomy prior to complete excision transorally.…”

Section: Discussionmentioning

confidence: 96%

Retropharyngeal neuroblastoma in a neonate: case report and literature review

et al. 2007

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Primary cervical neuroblastoma (NB) in neonates is extremely rare. We treated a 1-day-old male neonate who presented with stridor and feeding difficulty and was subsequently diagnosed with NB of the retropharynx. The tumor was excised in toto transorally, and no metastatic lesions were confirmed. Histopathology and molecular genetic analysis showed poorly differentiated NB with no N-myc amplification, stage I NB. He has had no signs of recurrence or adverse sequelae during 18 months of follow-up. We report our experience and review the literature.

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Section: Discussionmentioning

confidence: 96%

Retropharyngeal neuroblastoma in a neonate: case report and literature review

et al. 2007

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Primary Cervical Neuroblastoma

2017

Diagnostic Imaging: Head and Neck

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Spontaneously Regressing Retropharyngeal Neuroblastoma – A Rare Cause of Upper Airway Obstruction in a Neonate: A Case Report with Review of Literature

Piridi,

Manugu,

Kamuni

et al. 2024

Indian Pediatrics Case Reports

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Background: Retropharyngeal masses may rarely cause persistent respiratory distress, stridor, and feeding difficulties in a neonate. We report a rare case of a primary cervical neuroblastoma presenting as a retropharyngeal mass, which underwent spontaneous regression. Clinical Description: A 29-day-old male baby was referred for recurrent vomiting since day 10 of life followed by severe difficulty in breathing since day 14 of life. At admission, the baby had stridor, cyanosis with respiratory failure, without any facial dysmorphism or cardiovascular involvement. Management and Outcome: After initial stabilization, investigations showed pneumonia in chest X-ray, with no evidence of sepsis. On intubation, a retropharyngeal bulge was noticed which was later confirmed by direct laryngoscopy. Later, computed tomography delineated the soft-tissue mass extending from C2–C5. Endoscopy with marsupialization of the tumor was done, and on histopathological examination, it was diagnosed as a small round blue cell tumor, suggestive of neuroblastoma, along with positive immunohistochemistry. According to the International Neuroblastoma Staging System, the tumor belonged to Stage I. As the baby had started improving clinically, further management by a multidisciplinary team was collectively decided to continue conservative observation. On follow-up, there was spontaneous regression in size of tumor with no recurrence of symptoms till the last follow-up at 11 months. Conclusion: Neuroblastoma, the most common solid tumor malignancy in children, may rarely have a primary cervical presentation, causing breathing and feeding difficulties. Depending on the course of symptoms, a strategy of observation and close monitoring by a multidisciplinary team can be taken, as such tumors may regress spontaneously.

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Primary neuroblastoma: a rare cause of a retropharyngeal mass in a neonate

Cited by 3 publications

References 7 publications

Retropharyngeal neuroblastoma in a neonate: case report and literature review

Retropharyngeal neuroblastoma in a neonate: case report and literature review

Primary Cervical Neuroblastoma

Spontaneously Regressing Retropharyngeal Neuroblastoma – A Rare Cause of Upper Airway Obstruction in a Neonate: A Case Report with Review of Literature

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