Primary nerve-sheath tumours of the trigeminal nerve: clinical and MRI findings

Majoie, Charles B. L. M.; Hulsmans, F J; Castelijns, Jonas A.; Sie, L. H.; Walter, A.; Valk, Jacob; Albrecht, K. W.

doi:10.1007/s002340050713

Cited by 58 publications

(32 citation statements)

References 21 publications

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“…Majoie et al [26] and Rigamonti et al [27] described dumb-bells configuration of trigeminal schwannomas due to involvement of CPA and Meckel's cave. In one patient in the present study, the trigeminal schwannoma extended through the foramen ovale as was reported by Kapila et al [28].…”

Section: Discussionmentioning

confidence: 99%

Role of Magnetic Resonance Imaging in Evaluation of Cerebellopontine Angle Schwannomas

Singh

Thukral

et al. 2014

Indian J Otolaryngol Head Neck Surg

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The aim of the present study was to evaluate the role of Magnetic Resonance Imaging (MRI) to localize and characterize the MR imaging features of cerebellopontine angle schwannomas and to compare with surgical/ histopathological findings. It was a prospective study which included 19 patients, who presented with signs and symptoms s/o any lesion in the CP angle and were referred to the radiology department for MRI. All patients included in the study were subjected to detailed clinical history and physical examination following which MRI was carried out on Philips Gyroscan Achieva 1.5 Tesla unit and the standard protocol consisted of T1WI, T2WI, DWI and FLAIR images in axial, sagittal and coronal planes. Hearing abnormality was the most common presenting complaint in patients with CP angle schwannoma's followed by headache and tinnitus. Vestibulocochlear nerve was the most commonly involved nerve in patients with these lesions followed by involvement of trigeminal nerve. MRI was erroneous in giving provisional diagnosis of schwannoma in one case, which on subsequent surgery and histopathology was found to be a meningioma. The sensitivity of MRI for correctly diagnosing vestibular schwannoma was 100 % and specificity was 92.86 % with a positive predictive value of 94.12 % and accuracy of 96.67 %. MRI is considered as an excellent noninvasive investigation for CP angle schwannoma's. It can identify the site and extension of the lesions as well as the characteristic signal. Apart from diagnosing, MR imaging plays an important role in stratifying patients into appropriate treatment options.

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Section: Discussionmentioning

confidence: 99%

Role of Magnetic Resonance Imaging in Evaluation of Cerebellopontine Angle Schwannomas

Singh

Thukral

et al. 2014

Indian J Otolaryngol Head Neck Surg

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“…Plexiform neurofibroma (PNF) may occur at any age and is typically found in about one-third of patients with neurofibromatosis type 1 (NF-1). 1 PNF most commonly involves the trigeminal nerve, especially its 1st and 2nd divisions. Primary nerve sheath tumours of the trigeminal nerve may occur with a wide variety of symptoms and signs, including trigeminal sensory deficit, atypical neuralgia or paraesthesia, absent corneal reflex and diplopia, depending on lesion location.…”

Section: Introductionmentioning

confidence: 99%

Severe exophthalmos in trigeminal plexiform neurofibroma involving the orbit and the infratemporal fossa

Santaolalla

Sánchez

Ereño

et al. 2009

Journal of Clinical Neuroscience

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“…A diffuse neurofibroma involving the skin and subcutaneous tissues is a common variant of neurofibroma which is often seen in head and neck region and may involve the oral cavity [15]. In the head and neck, plexiform neurofibromas most commonly involve the fifth cranial nerve, especially the first and second divisions [16].…”

Section: Introductionmentioning

confidence: 99%

Oral soft tissue alterations in patients with neurofibromatosis

et al. 2011

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Our aim was to characterize the type and frequency of oral soft tissue alterations in neurofibromatosis. A total of 103 patients with neurofibromatosis 1 (NF1) and three patients with neurofibromatosis 2 (NF2) were clinically evaluated for their oral soft tissue alterations. Disturbing growths were removed from nine patients with NF1 and from one patient with NF2. The specimens were analyzed using routine histological methods and with immunohistochemistry using antibodies to S100, type IV collagen, CD34, neurofilament, and neuron-specific tubulin (TUBB3). Alterations including oral tumors, overgrowths of gingival soft tissue, and enlarged papillae of the tongue were discovered in 74% of NF1 patients. The results showed that three tumors clinically classified as plexiform neurofibromas and five out of six discrete mucosal tumors displayed histology and immunohistology consistent with that of neurofibroma. The histology of one palatal lesion resembled that of a scar, and the lesion removed from the patient with NF2 was classified as an amyloid tumor. To conclude, oral soft tissue growths are common findings in NF1, but most lesions do not require treatment and the patients may even not be aware of these alterations. Collagen IV, S100, and CD34 are useful biomarkers in the analysis of NF1-related oral soft tissue tumors. The clinicians should recognize that oral soft tissue alterations are relatively common in NF1. Some of the growths are disturbing, and plexiform neurofibromas may bear a risk of malignant transformation.

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Primary nerve-sheath tumours of the trigeminal nerve: clinical and MRI findings

Cited by 58 publications

References 21 publications

Role of Magnetic Resonance Imaging in Evaluation of Cerebellopontine Angle Schwannomas

Role of Magnetic Resonance Imaging in Evaluation of Cerebellopontine Angle Schwannomas

Severe exophthalmos in trigeminal plexiform neurofibroma involving the orbit and the infratemporal fossa

Oral soft tissue alterations in patients with neurofibromatosis

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