Primary myxopapillary ependymoma of the fourth ventricle with cartilaginous metaplasia: a case report and review of the literature

Chakraborti, Shrijeet; Govindan, Aparna; Alapatt, Jacob Paul; Radhakrishnan, M.; Santosh, Vani

doi:10.1007/s10014-011-0059-8

Cited by 22 publications

(17 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our case, the tumor cells were positive for GFAP and S-100 protein. EMA staining has been reported to be focal, 1) faintly positive, 18) or negative 2) in MPE, but staining for EMA was not found in our case. The optimal management of MPE is complete resection, but surgical procedures may facilitate spread of metastases.…”

Section: Discussioncontrasting

confidence: 45%

“…The cytological and histological diagnoses are determinative and the cytological features of MPE include myxoid background, hyaline globules, papillary structures, perivascular pseudorosettes, andothers. 9) Positive staining for GFAP, 2,20) S-100 protein, 2,19) and vimentin 6,10) has been reported in some MPEs. In our case, the tumor cells were positive for GFAP and S-100 protein.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Myxopapillary Ependymoma in the Third Ventricle Area and Sacral Canal: Dropped or Retrograde Metastasis?

Wang

Zhou

et al. 2013

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

Myxopapillary ependymoma (MPE) is a rare type of central nervous system neoplasm mostly located in the cauda equina and filum terminale regions. A previously healthy 22-year-old Chinese man presented with the first case of MPE in the third ventricle area and sacral canal initially manifesting as spinal cord compression. The patient was admitted with pain in the right lower extremity for 5 months and encopresis for 3 months. Magnetic resonance imaging of the lumbar spine revealed an intradural lesion at the S2 level. The patient accordingly underwent lumbar laminectomy surgery and gross total resection of the tumor. Shortly after surgery, a mass was found in the third ventricle. The patient subsequently underwent further craniotomy surgery, and the histopathological examination eventually revealed MPE. MPE usually undergoes intracranial retrograde metastasis, but we consider that our case was a dropped metastasis of the primary intracranial MPE. Neurosurgeons need to be aware of intracranial MPEs in patients with isolated spinal lesions, and long-term follow-up is important in patients who are diagnosed with MPE after surgical excision.

show abstract

Section: Discussioncontrasting

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Myxopapillary Ependymoma in the Third Ventricle Area and Sacral Canal: Dropped or Retrograde Metastasis?

Wang

Zhou

et al. 2013

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

show abstract

“…Of 12 cases that were tested for epithelial membrane antigen 58% were found positive, and all 7 cases tested for S-100 protein were positive [3,4,5]. …”

Section: Discussionmentioning

confidence: 99%

“…Cartilaginous metaplasia was found on the initial operation in 7 cases (64%), on the 2nd operation following adjuvant radiotherapy in 1 (9%) and on the 3rd operation following radiotherapy in 2 (18%) [3,4,5,10]. Our patient was the only one to have 5 resections in total and histological findings progressed from a grade II to more aggressive grade III anaplastic ependymoma following a year of chemotherapy and then, after a course of radiotherapy, to ependymoma with cartilaginous metaplasia.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Extensive Cartilaginous Metaplasia of Recurrent Posterior Fossa Ependymoma: Case Report and Review of the Literature

Boukas¹,

Joshi

Jenkins³

et al. 2013

Pediatr Neurosurg

View full text Add to dashboard Cite

Cartilaginous metaplasia in ependymomas is extremely rare and only few cases have been reported in the literature. We describe a case of a 5-year-old patient with a 5th recurrence of 4th ventricle ependymoma. He was previously treated with 4 resections, chemotherapy and radiotherapy. Histopathology revealed well-differentiated chondroid tissue occupying almost the entire lesion. Near total resection was achieved for the 5th time, but the patient died 3 months later achieving a total survival of 48 months, the 3rd longest reported in literature. Multiple resections of tumour recurrence provided a new insight in this very rare tumour, as it gave us the opportunity to observe the progression of tumour aggressiveness from grade II to grade III and finally to chondroid metaplasia. Cartilaginous metaplasia in posterior fossa ependymomas is a very atypical and challenging tumour with poor overall prognosis.

show abstract

Myxopapillary ependymoma in children: A study of 11 cases and a comparison with the adult experience

Cimino

Agarwal

Dehner

2014

Pediatric Blood & Cancer

View full text Add to dashboard Cite

show abstract

Primary myxopapillary ependymoma of the fourth ventricle with cartilaginous metaplasia: a case report and review of the literature

Cited by 22 publications

References 27 publications

Myxopapillary Ependymoma in the Third Ventricle Area and Sacral Canal: Dropped or Retrograde Metastasis?

Myxopapillary Ependymoma in the Third Ventricle Area and Sacral Canal: Dropped or Retrograde Metastasis?

Extensive Cartilaginous Metaplasia of Recurrent Posterior Fossa Ependymoma: Case Report and Review of the Literature

Myxopapillary ependymoma in children: A study of 11 cases and a comparison with the adult experience

Contact Info

Product

Resources

About