Primary myxoid chondrosarcoma of the breast

Farahat, Ahmed; Magdy, Nesreen; Elaffandi, Ahmed

doi:10.1308/003588414x13824511649210

Cited by 5 publications

(3 citation statements)

References 6 publications

(7 reference statements)

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“…By contrast, the study revealed a more severe prognosis for the patients that underwent simple lumpectomy. Notably, at the time of writing, a novel case report was published in the literature that used a similar conservative breast surgery approach ( 26 ), supporting the present approach of performing quadrantectomy instead of mastectomy.…”

Section: Discussionmentioning

confidence: 64%

Rare chondrosarcoma of the breast treated with quadrantectomy instead of mastectomy: A case report

et al. 2014

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Breast chondrosarcoma is a rare sarcoma that mainly occurs in females >50 years old. To the best of our knowledge, only 16 cases were reported in the literature prior to 2013 and all patients were surgically treated by mastectomy, with or without lymphadenectomy, which was occasionally preceded by neoadjuvant chemotherapy. However, the literature does not report the benefit of mastectomy compared with a more conservative surgery. The present study reports a novel case of extraskeletal chondrosarcoma of the breast. A 63-year-old female patient presented with a neoplasm localized in the upper-outer quadrant of the right breast. The palpable lesion with sharp margins was a firm parenchymatous mass, which was confirmed by ultrasonography and mammography. The patient underwent conservative quadrantectomy instead of mastectomy, followed by post-surgical chemotherapy. A positron emission tomography scan performed five months subsequent to the surgery revealed no remnants of the disease. The patient underwent a strict clinical and instrumental follow-up, and two and half years after surgery, there are no signs of recurrent disease. In conclusion, the present case is currently one of the two cases in which a more conservative quadrantectomy was performed, instead of mastectomy. This surgical approach did not lead to metastasis and resulted in a good follow-up for the patient.

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Section: Discussionmentioning

confidence: 64%

Rare chondrosarcoma of the breast treated with quadrantectomy instead of mastectomy: A case report

et al. 2014

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“…Only 18 cases of primary breast chondrosarcoma have been reported in the literature between 1967 and 2014. Until 2013 the gold standard was a radical mastectomy [7] , and conservative breast surgery was never part of the management of the 16 reported cases; in 2014, two cases of quadrantectomy were reported in the literature [8] , [9] , but the benefits of radical mastectomy compared with a more conservative surgery have not been mentioned. Mastectomy was associated with lymphadenectomy in 4 cases, associated with grafting in one case [2] ; it was preceded by neoadjuvant chemotherapy(with partial responce) in one case [6] and was followed by adjuvant radiotherapy in three cases.…”

Section: Discussionmentioning

confidence: 99%

“…The present case report describes a new case of primary mammary chondrosarcoma: by analysing the nature of the neoplasm, its dimensions, its suprafascial localisation, the necessity of wide margins of resection, the dimension of the breast, and the young age of the patient, and considering the absence of extra-lymph nodal and lymph nodal metastasis, it was decided to perform a skin-nipple-sparing mastectomy with the insertion of a mammary expander, rather than a definitive prosthesis, to allow the patient to undergo adjuvant radiotherapy. This surgical approach and the adjuvant radiotherapy were chosen with the consideration that the rare histological “myxoid chondrosarcoma” pattern of the tumour makes it chemoresistant [8] , and that hormone therapy has no rule in the treatment of pure mammary sarcomas. This fact is supported by immunohistochemical studies: the mesenchymal elements are positive both for S-100 and vimentin, but negative for common epithelial markers, such as cytokeratins and oestrogen and progesterone receptors [7] , [11] .…”

Section: Discussionmentioning

confidence: 99%

Skin-nipple-sparing mastectomy: The first approach in primary myxoid chondrosarcoma of the breast

Militello

Zabbia

Mascolino

et al. 2017

International Journal of Surgery Case Reports

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The primary mammary chondrosarcoma corresponds to less than 0,5% of the mammary malignancies. For the period ranging from 1967 to 2014, only 18 cases were reported in the literature.A 41 year old woman found a hard nodule on her external right superior quadrant/axillary prolongation through breast self-examination. The vacuum-assisted core biopsy (VACB) revealed “high grade extra-skeletal myxoid chondrosarcoma”. A skin-nipple-sparing mastectomy with the insertion of a mammary expander was performed. A protocol of adjuvant radiotherapy was also indicated.Until 2013, the gold standard was the radical mastectomy. By 2014, there were two cases of conservative approach to quadrantectomy. To our knowledge, this represents the first case in the literature in which a skin-nipple-sparing mastectomy has been performed on a primitive mesenchymal neoplasm of the breast. Such an oncoplastic approach was performed considering the young age of the woman, to assure the surgical radicality and a better quality of life to the patient.

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