Primary Multiple Cancers

Fried, B. M.

doi:10.1001/archsurg.1958.01290040078010

Cited by 38 publications

(3 citation statements)

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“…The criterion for a tumor's being "synchronous" or "metachronous" is 6 months or 1 year depending on the study, but this research adopted 6 months as a standard [10, 11]. The study conducted by Kim et al [12] reported that 36.3% chance of a tumor's being synchronous and 63.7% chance of its being metachronous and those results are quite similar to the results of our research.…”

Section: Discussionsupporting

confidence: 86%

Clinical Characteristics of Colorectal Cancer Patients With a Second Primary Cancer

Lee

Kim

2014

Ann Coloproctol

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PurposeThe incidence of colorectal cancer is increasing due to a westernized dietary lifestyle, and improvements in treatment and diagnostic tools have resulted in more patients being confirmed of having multiple primary cancers. However, studies regarding multiple primary cancers are insufficient. In this study, the clinical aspects of patients with primary multiple cancers, including colorectal cancers, were investigated, and the results were compared to those of patients with primary colorectal cancer only.MethodsSeven hundred eighteen patients who received surgery for colorectal cancer between March 2003 and September 2012 in CHA Medical Center were enrolled. A retrograde cohort was done for comparison of the two groups: those with and those without multiple primary cancer. The analysis was done according to sex, age, tumor location, tumor size, metastatic regional lymph-node number, vascular/lymphatic microinvasion, staging, tumor markers, microsatellite instability, and C/T subgroup of polymorphism in methylenetetrahydrofolate reductase.ResultsOf the 718 subjects, 33 (4.6%) had multiple primary cancers: 12 (36.4%) synchronous and 21 (63.6%) metachronous. The malignancy most frequently accompanying colorectal cancer was gastric cancer, followed by thyroid, prostate, and esophageal malignancies in that order. In the comparison between groups, mean age, tumor location, and microsatellite instability showed statistically significant differences; others parameters did not.ConclusionThe incidence of multiple primary cancers, including colorectal cancer, is increasing. Therefore, defining the characteristics of patients with multiple primary cancers is crucial, and those characteristics need to be acknowledged in the follow-up of colorectal cancer patients.

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Section: Discussionsupporting

confidence: 86%

Clinical Characteristics of Colorectal Cancer Patients With a Second Primary Cancer

Lee

Kim

2014

Ann Coloproctol

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“…Some cancer cells have also been reported to produce chemokines that induce lymphocytic migration. 3 In the reported case, the pathogenesis of the composite tumor consisting of carcinoma and lymphoma could be attributed to both hypothetical mechanisms, although it is also possible that the mixed tumor occurred coincidentally.…”

Section: Conflict Of Interestmentioning

confidence: 77%

A case of mixed tumor formed by metastasis of urothelial carcinoma and malignant lymphoma to the same lymph nodes

et al. 2021

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Introduction: Mixed tumor in the same lymph nodes is extremely rare and no previous reports have described mixed tumor comprising urothelial carcinoma and malignant lymphoma. Case presentation: A 71-year-old woman visited a local clinic with a main complaint of hematuria. Imaging revealed right hydronephrosis and a mid-ureter tumor shadow. Positron emission tomography-computed tomography showed high uptake of fluorodeoxyglucose in para-aortic lymph nodes. Abdominal para-aortic lymph node biopsy was performed. Pathology showed urothelial carcinoma and malignant lymphoma in the same lymph nodes, where a mixed tumor was diagnosed. Conclusion:We encountered a case of mixed tumor of urothelial carcinoma and Hodgkin lymphoma, which metastasized to the same tissues.

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“…Numerous authors have now described many different combinations of multiple malignancy, including carcinoma and sarcoma in the same patient and “cancer to cancer” metastases (bobbing, 1958; Fried, 1958; Moertel, 1968; Woodruff and Julian, 1969; Rajhvajn et al , 1972; Silverman, 1972).…”

Section: Discussionmentioning

confidence: 99%