Primary multifocal osseous Hodgkin's lymphoma

Langley, Clare R; Garrett, Simon J.; Urand, Jill; Kohler, Janice A.; Clarke, Nick M P

doi:10.1186/1477-7819-6-34

Cited by 37 publications

(34 citation statements)

References 10 publications

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“…A case with initial involvement of the sternum was described in the present study, which is an uncommon phenotype in PBL. To the best of our knowledge, only six such cases have been previously reported in the medical literature (13)(14)(15)(16)(17)(18). In addition, the clinical characteristics are nonspecific, making the diagnosis difficult at the onset.…”

Section: Discussionmentioning

confidence: 99%

Primary sternum diffuse large B-cell lymphoma: A case report and review of the literature

Tong

Zhang

et al. 2015

Oncology Letters

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Abstract. Primary bone lymphoma (PBL) is a rare disease, accounting for >1% of all cases of malignant lymphoma. Diffuse large B-cell lymphoma (DLBCL) is the most common histological type of PBL. The present study reported the case of a 68-year-old male with primary bone DLBCL, originally occurred in the sternum, which is a rare form of presentation. Computed tomography (CT), magnetic resonance imaging and bone emission CT were performed, followed by immunohistochemical analysis of a biopsy specimen, and the results were used to establish the diagnosis. At the time of diagnosis, no osseous involvement was observed. The clinical, radiological and histological features of PBL can mimic other medical conditions, thereby making the diagnosis difficult, and frequently leading to delays in treatment. The present study investigated the clinical features, management and prognosis of PBL, and reviewed previous relevant cases.

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Section: Discussionmentioning

confidence: 99%

Primary sternum diffuse large B-cell lymphoma: A case report and review of the literature

Tong

Zhang

et al. 2015

Oncology Letters

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“…Попытки сопоставить наши наблюдения с данными литературы оказались затруднитель-ными, прежде всего, не только из-за упоминания о первичных опухолевых поражениях грудины у детей как о крайне редких [2], но и из-за того, что при типичных для этой возрастной группы системных лимфопролиферативных заболевани-ях -неходжкинской лимфоме и лимфоме Ход-жкина [3][4][5] -поражение грудины крайне редко выступает как первично манифестирующий очаг. Вместе с тем нельзя не отметить, что в структу-ре злокачественных новообразований человека первичные опухоли грудной стенки составляют 0,2-2 % [6], а среди всех опухолей грудины зло-качественный характер имеют 85 % поражений, значительная часть из которых приходится имен-но на хондросаркому и злокачественные лимфо-мы [7][8][9].…”

Section: Discussionunclassified

“…Определение категории нодулярного склероза считает-ся целесообразным в рамках накопления данных для дальнейших исследований. ведет к продолжительному неадекватному лече-нию и поздней диагностике [2,5,10,11]. Актив-ная хирургическая тактика при этом имеет два принципиальных преимущества: бактериологическое исследование операцион-ного материала позволяет исключить инфек-ционную этиологию процесса, а морфологи-ческое -верифицировать опухоль.…”

Section: Discussionunclassified

Malignant tumors of the sternum in pediatric patients: report of two cases and literature review

Малетин

Зорин

Gileva

et al. 2017

Pediatr Traum Orthop Reconstr Surg

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Деструктивные поражения осевого скелета встречаются относительно редко в повседневной практике детского травматолога-ортопеда. Вместе с тем, клинико-лучевая симптоматика деструктивных изменений костной ткани характерна для опухолевых и инфекционно-воспалительных поражений костей. Данная симптоматика не всегда четко указывает на конкретную нозологическую единицу, а дифференциальная диагностика без исследования биологического материала из патологической зоны сложна. Данные утверждения особенно актуальны для поражений грудины, опухолевые процессы которой в 85 % имеют злокачественный характер. В статье представлены два редких клинических наблюдения детей с первичным злокачественным новооб-разованием грудины. Проведен анализ клинико-лучевых и патоморфологических данных. Показана важность ранней гистологической верификации процесса для определения тактики и выбора адекватного лечения. Про-веден краткий обзор литературы, посвященной злокачественным опухолям грудины у детей.Ключевые слова: поражение грудины, лимфома Ходжкина, дети, хондросаркома. Destructive changes in the bones are rarely observed in daily practice of pediatric orthopedic surgeons. Clinical and X-ray signs of destructive changes in the bone tissue are characteristic of tumoral, infectious, and inflammatory damages of bones. These signs do not always correspond to a specific disease, and differential diagnostics without histological evaluation is difficult. This is especially true for tumors of the sternum, 85% of which are malignant. Two rare clinical cases of primary malignant sternal neoplastic lesions in pediatric patients, and a detailed analysis of their clinical, radiologic, and morphologic data are presented. The importance of early histological verification for determining the choice of treatment is demonstrated. A short literature review is also presented. MALIGNANT TUMORS OF THE STERNUM IN PEDIATRIC PATIENTS: REPORT OF TWO CASES AND LITERATURE REVIEWKeywords: sternum malignant tumor, Hodgkin's lymphoma, children, chondrosarcoma.Хронические деструктивные поражения ске-лета относительно редко встречаются в практике детских хирургов и ортопедов. Возможно, имен-но поэтому каждый случай такого заболевания представляет серьезную проблему, сопровождает-ся длительным наблюдением, поздно диагности-руется, нередко при этом выполняются неодно-кратные и не всегда оправданные хирургические вмешательства. Дифференциальный ряд таких деструкций, как правило, ограничивается инфек-ционными (чаще -туберкулезными) и опухо-левыми процессами, и, хотя первые встречаются несравнимо чаще, именно онкологическая насто-роженность позволяет раньше диагностировать опухоли, прежде всего благодаря лучевым и мор-фологическим методам.

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“…The average time to diagnosis is 6-8 months from the onset of symptoms [2]. There is considerable overlap in radiological features with bone tuberculosis and differentiation from other benign and malignant etiologies is challenging [3].…”

mentioning

confidence: 99%

“… A. Prakash et al The diagnosis of osseous HL is difficult [2]. The average time to diagnosis is 6-8 months from the onset of symptoms [2].…”

mentioning

confidence: 99%

Hodgkin Lymphoma Presenting with Multifocal Osseous Lesions in a Child

Prakash

Dinand

Anupam

et al. 2012

Pediatric Hematology and Oncology

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Multiple osseous lesions in children are rare and suggest the possibilities of Langerhans cell histiocytosis (LCH), malignancies, enchondromatosis, multifocal osteomyelitis, and tuberculosis [1]. We present a 12-year-old boy with fever for 7 months and pain in the lower back and left hip joint for 5 months, with multiple sclerotic, lytic, and mixed osseous lesions in the axial and appendicular skeleton (see Figure 1). He had received antitubercular treatment for 5 months for suspected tuberculosis of the spine, with no clinical improvement. Aspirin and methotrexate prescribed for suspected juvenile rheumatoid arthritis had provided no relief of symptoms. He had no history of recurrent infections. His HIV was negative by ELISA and his serum immunoglobulin levels were normal. There was no palpable lymphadenopathy or organomegaly. Bone marrow examination was normal. Computed tomography (CT) showed enlarged mediastinal (largest 2.8 × 2 cm) and abdominal lymph nodes (largest 2.7 × 1.3 cm), sclerotic and lytic lesions of 5th rib, sternum, and various vertebrae. Endoscopic fine needle aspiration cytology (FNAC) of mediastinal lymph nodes, CT-guided FNA-biopsy of the 5th rib, and paravertebral mass as well as a laparoscopic biopsy of mesenteric and iliac lymph nodes were done in a staged manner, but all showed reactive changes. Finally, a bone biopsy from an occipital mass lesion, which appeared 3 weeks later, was suggestive of mixed-cellularity Hodgkin lymphoma (HL) (see Figure 2) with immunohistochemistry positive for CD30, CD15, and EBV. He was started on ABVD chemotherapy for stage IV-B HL. Fever, limp, and bone pain subsided dramatically after 2 weeks of chemotherapy. In view of residual disease after four ABVD cycles on positron emission tomography-CT scan, he received further four BEACOPP cycles. He has been disease free for 30 months.  Multifocal Osseous Lesions in a Child FIGURE 1 Chest X-ray (postero-anterior view) showing a right hilar and upper mediastinal lymphadenopathy with a lytic lesion at the posterior end of (A) the right 5th rib. (B) Anterior and (C) posterior views of 99m Tc methylene diphosphonate ( 99m Tc MDP) bone scan showing increased osteoblastic activity in the skull, multiple ribs and vertebrae, bilateral pelvic bones, and the proximal appendicular skeleton. Copyright C Informa Healthcare USA, Inc.

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Primary multifocal osseous Hodgkin's lymphoma

Cited by 37 publications

References 10 publications

Primary sternum diffuse large B-cell lymphoma: A case report and review of the literature

Primary sternum diffuse large B-cell lymphoma: A case report and review of the literature

Malignant tumors of the sternum in pediatric patients: report of two cases and literature review

Hodgkin Lymphoma Presenting with Multifocal Osseous Lesions in a Child

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