Primary multifocal osseous Hodgkin disease: a case report and review of the literature

Gebert, Carsten; Hardes, Jendrik; Ahrens, H.; Buerger, H.; Winkelmann, Winfried; Gosheger, G.

doi:10.1007/s00432-004-0641-0

Cited by 30 publications

(19 citation statements)

References 34 publications

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“…To the best of our knowledge, only 25 cases of primary bone HL involving either single or multiple bones have been reported in the literature [6,7].…”

Section: Introductionmentioning

confidence: 97%

Clinical characterization and prognostic factors of primary lymphoma of bone in case of Chinese patients

et al. 2010

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Primary lymphoma of bone (PLB) is a very rare neoplasm. Many aspects of this entity have not been well defined or reported in Chinese population. The purpose of our study is to identify the prognostic factors of PLB. Twenty-five patients newly diagnosed with PLB were included in this retrospective study. The main pathologic subtype of PLB was diffuse large B-cell lymphoma (DLBCL), followed by anaplastic large-cell lymphoma. The pelvis was the most commonly involved site (13 cases, 52%). The 5-year overall survival (OS) rate was 55.0%. Cox regression analysis demonstrated that IPI score was an independent prognostic factor of survival (RR = 8.46, P = 0.013). The mean survival time (MST) was 90.3 months for patients with radiation and 54.0 months for those without radiotherapy (P = 0.033). Patients who received the anti-CD20 monoclonal antibody rituximab therapy showed a favorable survival trend, but not significant benefit (MST: 74.5 months vs. 68.6 months, P = 0.149). Some clinical characteristics in the Chinese population are different from those in westerners. The frequency of T-cell subtypes is higher, and the pelvis is the most commonly involved site. Irradiation plus chemotherapy may be better than chemotherapy alone. The role of bisphosphonates and rituximab in PLB therapy warrants further investigation.

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“…To the best of our knowledge, only 25 cases of primary bone HL involving either single or multiple bones have been reported in the literature [6,7].…”

Section: Introductionmentioning

confidence: 97%

Clinical characterization and prognostic factors of primary lymphoma of bone in case of Chinese patients

et al. 2010

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“…[8] In recent years, with combined modality treatments (radioand chemotherapy) the long term prognosis of patients with osseous HD appears good. [7,9] The use of surgery is restricted to obtaining open biopsies or treating mechanical or neurological complications. [4] CONCLUSION Although extremely rare, the primary osseous Hodgkin's lymphoma should be remember in the differential diagnosis of lytic lesions, especially involving the pelvis bones and vertebrae.The practical interest is to make early diagnosis because POHL have more favorable prognosis compared with other malignant bone lesions.…”

Section: Discussionmentioning

confidence: 99%

Sacral pain as the initial symptom in primary Hodgkin′s lymphoma of bone

2013

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Progressive painless enlargement of peripheral lymph nodes is the most common presentation of Hodgkin's lymphoma. The bone involvement is seen particularly in the later stages, but very rarely in early stages of the disease. Primary osseous Hodgkin lymphoma is exceedingly rare. Here, we report a case of Primary osseous Hodgkin lymphoma in a 35-year-old male presenting with osteolytic lesions of iliac and sacral bone without other symptoms. Histopathology examination revealed Hodgkin's disease. All other investigations (including computed tomography of the chest, abdomen and pelvis, bone marrow aspiration) were negative for occult disease. Polychemotherapy was started and the symptoms resolved. The case report highlights the importance of clinical suspicion of primary Hodgkin lymphoma of the bone, especially those involving the pelvis bones.

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“…Extranodal involvement is much less common in HL than in non-HL [8][9][10]. In this retrospective study of 384 newly diagnosed HL cases, extralymphatic disease was diagnosed in 19% of cases.…”

Section: Discussionmentioning

confidence: 99%

“…PET/CT scanning has emerged as an important tool in the staging of patients with HL, and this adds significantly to the staging information obtained using other standard radiographic methods [4,5]. In the diagnosis and management of HL, 18F-fluorodeoxyglucose PET/CT is a functional imaging modality that has become a standard tool complementing contrastenhanced CT scans [9][10][11][12]. Several studies have shown that PET/CT helps to make a more accurate identification of the correct pretreatment stage in HL compared with contrast-enhanced CT, although PET/CT upstages disease from an early to an advanced stage in only 10-15% of patients whose treatment ultimately undergoes modification [4,5].…”

Section: Discussionmentioning

confidence: 99%

Bone Involvement in Hodgkin’s Lymphoma: Clinical Features and Outcome

et al. 2018

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Hodgkin’s lymphoma (HL) is now a highly curable disease, with an improving 5-year survival rate that has now reached 86%. At the time of presentation, HL is usually almost entirely confined to the lymph nodes. We performed a retrospective single-institution study of 384 cases with a median follow-up of 44 months, with the aim of identifying clinical and radiological characteristics and outcomes of patients with bone HL; 32 patients (8%) had primary bone involvement, always with concurrent nodal disease. These included 22 men (69%) and 10 women (31%) with the median age as 41 years. Advanced stages and nodular sclerosis histology prevailed among the subgroup. Radiographic features of bone HL are not specific but indicate a destructive malignant process with osteosclerosis and/or osteolysis. With current chemotherapeutic regimens, the long-term prognosis of patients with osseous HL appears good. The presence of bone lesions in HL should not be interpreted as implying a worse prognosis than without bone involvement.

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Primary multifocal osseous Hodgkin disease: a case report and review of the literature

Abstract: Reviewing the few reported cases, osseous HD must be distinguished from systemic HD with diffuse bone marrow involvement and from osseous metastases in advanced stage of disease because it seems to have a better prognosis.

Cited by 30 publications

References 34 publications

Clinical characterization and prognostic factors of primary lymphoma of bone in case of Chinese patients

Clinical characterization and prognostic factors of primary lymphoma of bone in case of Chinese patients

Sacral pain as the initial symptom in primary Hodgkin′s lymphoma of bone

Bone Involvement in Hodgkin’s Lymphoma: Clinical Features and Outcome

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