Primary multifocal anaplastic large cell lymphoma with eyelid involvement: a case
            report

Gargallo-Benedicto, A.; Bayo-Calduch, Patricia; Olate-Pérez, Á.; Pérez-Mestre, Desamparados; Duch-Samper, A.

doi:10.5935/0004-2749.20190094

Cited by 2 publications

(2 citation statements)

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“…28 Primary cutaneous ALCL has a more favorable prognosis than systemic ALCL, with a 5-year survival of approximately 90%. 1,28 Complete spontaneous regression can be observed in up to 25% 29 of primary cutaneous ALCL. WHO-HAEM, in its 4th and 5th editions, separated primary cutaneous ALCL from the ALCL subfamily and classified it under the umbrella of primary cutaneous T-cell lymphomas to acknowledge its distinct clinicopathological characteristics and highly favorable prognosis in contrast to systemic ALCL.…”

Section: Anaplastic Large Cell Lymphomamentioning

confidence: 99%

Anaplastic Large Cell Lymphoma With Intraocular or Ocular Adnexal Involvement: A Case Report and Systematic Review

Rafizadeh,

Ghahvehchian,

Rajabi

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To review the existing literature on patients with anaplastic large cell lymphoma (ALCL) affecting the globe and/or ocular adnexa, and to present a report documenting the clinical course of a patient with ALCL that involved their globe and ocular adnexa. Methods: PubMed, Scopus, and Google scholar were systematically searched for all cases of ALCL involving intraocular or adnexal ocular structures from inception to May 2023. Moreover, a new reported case added to the cases found in searches. Results: The review identified 1680 studies, with 8 meeting inclusion criteria. A total of 9 patients were included with a mean age of 29.7 years (median: 30.0, range: 1.3–48). Primary ALCL was present in 5/9 (55.6%) patients. The most common ophthalmic manifestations included periorbital swelling (5/8), chemosis (5.8), and decreased vision (5/7). Misdiagnoses were initially made in 3 patients, and the lag time to correct diagnosis from 3 weeks to 3 months. CD30 expression was positive in all cases, and 6/9 patients were positive for anaplastic lymphoma kinase, resulting in 6/9 patients being diagnosed with anaplastic lymphoma kinase-positive ALCL. In terms of management modalities, chemotherapy was administered in 8/9 patients, while radiation therapy was utilized in 4/9 patients, and 2 underwent autologous stem cell transplantation. Five (55.6%) patients succumbed to ALCL while 4 (44.4%) were alive and disease-free at the last follow-up. The median times from the initial presentation of ALCL to death, ophthalmic presentation to death, and diagnosis to death were 4.12 months (range: 1.1–168.0), 2.62 months (range: 1.1–144), and 4.00 months (range: 0.10–168), respectively. The median follow-up duration was 21.0 months (range: 1.1–168.0). Conclusions: ALCL involving the globe and ocular adnexa is a rare and highly malignant tumor that can mimic benign clinical conditions. Early biopsy and aggressive treatment with chemotherapy regimens such as CHOP and radiation therapy may be useful.

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Section: Anaplastic Large Cell Lymphomamentioning

confidence: 99%

Anaplastic Large Cell Lymphoma With Intraocular or Ocular Adnexal Involvement: A Case Report and Systematic Review

Rafizadeh,

Ghahvehchian,

Rajabi

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…They may be intact or ulcerated (Figure 7a). [38][39][40][41][42][43][44][45][46] Solitary tumours often masquerade as basal cell carcinoma, squamous cell carcinoma and keratoacanthoma. 41…”

Section: Primary Cutaneous Anaplastic Large-cell Lymphomamentioning

confidence: 99%

Eyelid involvement of primary cutaneous lymphomas: A clinical perspective

Baykal

Atci

2023

Aust J Dermatology

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Eyelids may be affected in systemic, ocular adnexal and primary cutaneous lymphomas (PCLs). The frequency of eyelid involvement in PCLs is still not well known and it is not a predilection site for any type. While primary cutaneous T‐cell lymphomas (CTCLs) are more commonly seen than primary cutaneous B‐cell lymphomas (CBCLs), especially mycosis fungoides (MF) as by far the most frequent type, B cell lymphomas are reported to be the commonest type in eyelid localization on the contrary. PCLs may be located on the eyelids, as the sole manifestation or in association with the involvement of other parts of the eye and elsewhere of the body. MF may present with a rich spectrum of clinical features on the eyelids mostly seen in folliculotropic subtype and advanced‐stage disease. Erythematous scaly patches or plaques representing the most commonly encountered eyelid MF lesions may mimic many other dermatological conditions. Diffuse thickening, oedema, poikilodermic changes, atrophy and wrinkling are other suggestive findings of eyelid MF. Milia‐like papules, madarosis and ectropion are also seen in the folliculotropic variant of MF, as ectropion is more typical for Sezary syndrome. Eyelids are also a typical location for tumoural MF which has been suggested as a poor prognostic indicator in MF. Papulonodular lesions, large tumours, ulceration, diffuse infiltration, oedema and subcutaneous atrophy on the eyelids may also be seen in other types of PCLs. Keep in mind, the rich clinical spectrum of PCLs on the eyelids may be crucial in early diagnosis in this special localization.

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Primary multifocal anaplastic large cell lymphoma with eyelid involvement: a case report

Cited by 2 publications

References 0 publications

Anaplastic Large Cell Lymphoma With Intraocular or Ocular Adnexal Involvement: A Case Report and Systematic Review

Anaplastic Large Cell Lymphoma With Intraocular or Ocular Adnexal Involvement: A Case Report and Systematic Review

Eyelid involvement of primary cutaneous lymphomas: A clinical perspective

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