Primary mucosal melanoma of the head and neck. Comparison of clinical presentation and histopathologic features of oral and sinonasal melanoma

McLean, Nicolas; Tighiouart, Mourad; Müller, Susan

doi:10.1016/j.oraloncology.2008.01.014

Cited by 120 publications

(129 citation statements)

References 16 publications

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“…Upon histopathologic review of the cases, we found that not only did the cell types differ significantly among the cases, but the majority of individual cases displayed a polymorphic cell population, with 50 % demonstrating a spindle cell population, 50 % epithelioid cells, 37.5 % oval cells, 28.1 % round blue cells, and 12.5 % clear cells. Our ''round blue cell'' category includes previously described ''neuroendocrine-like'' [17] or ''lymphoma-like'' [18] morphology, as well as plasmacytoid cells. Because of this predominantly polymorphic, non-epithelial cell population, a malignant appearing proliferation with more than one cell type should be viewed with high suspicion for melanoma.…”

Section: Discussionmentioning

confidence: 99%

Melanoma of the Oral Cavity: an Analysis of 46 New Cases with Emphasis on Clinical and Histopathologic Characteristics

Smith

Bhattacharyya

Cohen

et al. 2016

Head and Neck Pathol

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Melanoma of the oral cavity is a rare malignancy that carries a poor prognosis. We identified 46 new cases of both primary and metastatic melanoma to the oral cavity. Following IRB approval, these cases were obtained from the Oral Pathology Biopsy Service archives of the UF College of Dentistry (1994Dentistry ( -2014, the UK College of Dentistry (1997Dentistry ( -2015, and the UM Medical Center . All slides were reviewed. The location, age, race, gender, clinical impression, duration of lesion, histopathologic diagnosis, and histopathologic features were recorded. Cases from the facial skin and those with an ambiguous diagnosis were excluded. Forty-six cases fulfilled the inclusion criteria with 32 primary cases, 11 known metastases, and 3 cases where metastasis could not be excluded. The primary cases included a total of 20 females and 12 males with an average age of 66.7 (range 27-95), and the majority (80 %) of the patients were Caucasian when race was known. Twenty-two of the 32 primary cases (68.8 %) were located in the maxillary mucosa, 5 in the mandibular mucosa or bone, and 5 in other locations. The clinicians' impressions varied from benign fibrous growths to high grade malignancies. The histopathology varied widely among the cases, however two cell types predominated (often in combination): epithelioid cells (50.0 %) and spindle cells (50.0 %). Only 53.1 % demonstrated melanin pigmentation. Oral melanoma remains one of the most diverse clinical and histopathologic diagnoses. Better understanding of this neoplasm may promote earlier diagnosis and may lead to improved outcomes.

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Section: Discussionmentioning

confidence: 99%

Melanoma of the Oral Cavity: an Analysis of 46 New Cases with Emphasis on Clinical and Histopathologic Characteristics

Smith

Bhattacharyya

Cohen

et al. 2016

Head and Neck Pathol

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“…Overall, MMHN has a poor prognosis, which is reflected in the five-year survival rate of 10-39% [1,5,6,14].…”

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confidence: 99%

Primary mucosal melanoma of the head and neck in Denmark, 1982–2012: Demographic and clinical aspects. A retrospective DAHANCA study

et al. 2016

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Background The study was performed to determine the epidemiological, clinical, and histopathological characteristics and prognosis of primary mucosal melanoma of the head and neck (MMHN) in Denmark. Material and methods This was a national retrospective multicenter study of patients diagnosed with MMHN between 1982 and 2012 in Denmark. Data were retrieved from national databases and patient records. Incidence trends were examined for the entire period. We prepared survival curves and performed univariate and multivariate analysis for the period 1992-2012 to identify possible prognostic factors. Results No significant trends in incidence were found in the study period. The three-year overall and disease-free survival rates for MMHN were 46.5% and 35.5%, respectively. Negative margins was an independent predictor of disease-free survival, and age below 65, absence of distant metastases, and low overall TNM stage were predictors of overall survival. Radiotherapy did not improve survival significantly. Recurrence rates were high, even for patients with negative margins. Conclusions MMHN remains a rare disease with a poor prognosis, particularly for patients aged over 65, those with distant metastasis, and those with advanced TNM stage. Importantly, the rate of recurrence is lowest in patients with negative margins.

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“…12,13 Sinonasal melanoma tends to have a high rate of locoregional and distant failure and to carry poor outcome with a median survival of 9-52 months and an overall 5-year survival rate of 0% to 50%. [4][5][6][7][8] To date, more than one thousand cases of sinonasal melanomas have been reported in the literature. [4][5][6][7][8] Sinonasal mucosal melanoma is a tumor that usually occurs in the seventh decade of life and rarely before the fourth decade, as found in our study.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7][8] To date, more than one thousand cases of sinonasal melanomas have been reported in the literature. [4][5][6][7][8] Sinonasal mucosal melanoma is a tumor that usually occurs in the seventh decade of life and rarely before the fourth decade, as found in our study. In the present study, the mean and median age of our patients was 65 years, which is consistent with the results of the literature review in which average mean age of 683 patients in the reported series was 64.5 years.…”

Section: Discussionmentioning

confidence: 99%

“…1,4 The presence of positive lymph nodes in sinonasal mucosal melanomas has been considered as a poor prognostic factor in some studies. 1,5,6 The treatment of choice in mucosal malignant melanoma is surgery followed by radiotherapy, particularly in cases of small or doubtful margins of resection. 7 The prognosis of mucosal malignant melanoma is poor with 0% to 50% of 5-year survival.…”

Section: Introductionmentioning

confidence: 99%

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Melanoma primário de mucosa do trato nasossinusal: relato de 18 pacientes e análise de 1077 pacientes na literatura

Khademi¹,

Bahranifard²,

Nasrollahi³

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

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The present study aimed at reporting on the characteristics, prognostic factors and treatment outcomes of 18 cases of nasosinusal mucosa melanoma, and do a literature review on the subject.Methods: between 1995 and 2005, 18 patients consecutively diagnosed with nasosinusal mucosa melanoma were managed in our institution. We reviewed the literature in PubMed and Scopus in order to find the main series from studies associated with this topic. We found a total of 35 series, involving 1,077 patients with nasosinusal mucosa melanoma.Results: we found 16 men and 2 women, with age at presentation between 51 and 80 years (median of 58 years). All these patients were submitted to surgical excision followed by radiotherapy with or without chemotherapy. The survival median was 15 months, and the 5-year general survival had a percentage value of 23%. Considering our univariate analysis: tumor staging and complete remission after initial treatment were deemed relevant prognostic factors. Nonetheless, considering the multivariate analysis, only disease stage was statistically significant. Conclusion:nasosinusal melanoma is a rare and aggressive tumor, with high loco-regional and distant failure rates, and poor treatment outcomes. Notwithstanding, in a literature review we found significant improvements considering the 5-year survival for recent series when compared to previously reported ones. Braz J Otorhinolaryngol. 2011;77(1):58-64. ORIGINAL ARTICLE

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Primary mucosal melanoma of the head and neck. Comparison of clinical presentation and histopathologic features of oral and sinonasal melanoma

Cited by 120 publications

References 16 publications

Melanoma of the Oral Cavity: an Analysis of 46 New Cases with Emphasis on Clinical and Histopathologic Characteristics

Melanoma of the Oral Cavity: an Analysis of 46 New Cases with Emphasis on Clinical and Histopathologic Characteristics

Primary mucosal melanoma of the head and neck in Denmark, 1982–2012: Demographic and clinical aspects. A retrospective DAHANCA study

Melanoma primário de mucosa do trato nasossinusal: relato de 18 pacientes e análise de 1077 pacientes na literatura

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