Primary mucosa-associated lymphoid tissue lymphoma of the gallbladder: report of a case harboring API2/MALT1 gene fusion

Bisig, Bettina; Copie‐Bergman, Christiane; Baia, Maryse; Gaulard, Philippe; Delbecque, Katty; Fassotte, Marie-France; Boniver, Jacques; Leval, Laurence de

doi:10.1016/j.humpath.2009.02.018

Cited by 14 publications

(15 citation statements)

References 13 publications

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“…This protein inhibits apoptosis by NF-κB-mediated upregulation of apoptotic inhibitor genes and induces antigenindependent proliferation with formation of MALT lymphoma [7,8]. Recently, Bisig et al described a case of gall bladder MALT lymphoma with t(11;18)(q21;q21) similar to that seen in the stomach [2]. Although MALT lymphomas may present incidentally, the patients should undergo a complete staging workup and should be followed up for recurrence by standard history, physical examination and laboratory work at reasonable intervals.…”

Section: Discussionmentioning

confidence: 99%

“…Primary extranodal marginal zone lymphoma of MALT in the gall bladder is the most frequently reported nonHodgkin lymphoma (NHL) subtype for this location representing 8 of the 18 cases (44%) of primary NHL of the gall bladder described in the literature up to 2009 [1,2]. Of these cases cases, six presented clinically with either an enlarged gall bladder with diffuse wall thickening or a probable mass lesion with or without portahepatic lymphadenopathy, mimicking gall bladder adenocarcinoma [2][3][4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

“…Of these cases cases, six presented clinically with either an enlarged gall bladder with diffuse wall thickening or a probable mass lesion with or without portahepatic lymphadenopathy, mimicking gall bladder adenocarcinoma [2][3][4][5][6][7]. One of the cases as described by Tsuchiya et al showed Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Although MALT lymphomas may present incidentally, the patients should undergo a complete staging workup and should be followed up for recurrence by standard history, physical examination and laboratory work at reasonable intervals. When the tumour is localised only to the gall bladder, then cholecystectomy alone is considered curative with excellent prognosis [1,2,7]. Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Secondary infiltration of the gall bladder by lymphoma has been well described in literature; however, primary lymphomas of mucosa-associated lymphoid tissue (MALT) within the gall bladder are extremely rare with only eight cases reported in the medical literature [1,2]. Here we describe an incidental presentation of marginal zone lymphoma of MALT in a gall bladder removed for cholelithiasis.…”

Section: Introductionmentioning

confidence: 90%

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Incidental Presentation of Gall Bladder MALT Lymphoma

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et al. 2010

J Gastrointest Canc

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

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Incidental Presentation of Gall Bladder MALT Lymphoma

Bagwan

Ping

Lavender

et al. 2010

J Gastrointest Canc

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Melanocytic, Neuroectodermal, Germ Cell, Rhabdoid, Perivascular Epithelioid Cell, Hemolymphatic, and Metastatic Tumors of the Gallbladder

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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The gallbladder is involved by a wide variety of non-epithelial tumors, apart from mesenchymal neoplasms. Visceral malignant melanoma develops in the biliary tract, including the gallbladder. As both primary and metastatic gallbladder melanomas may show similar of the same growth patterns, the differential diagnosis between these two conditions is often difficult. Primary gallbladder melanoma is more likely if the tumor shows a polypoid or lobulated and in particular papillary growth pattern, is a solitary lesion, and is associated with junctional activity in the adjacent mucosa. In contrast, metastatic lesions are more commonly multiple, flat, and without junctional changes. Apart from neuroendocrine tumors, other neuroectodermal neoplasms can develop as primary tumors in the gallbladder. Rare primary neoplasms in this organ include germ cell tumors, rhabdoid tumors, perivascular epithelioid cell tumors, and hemolymphatic neoplasms. Apart from malignant melanoma, numerous other malignancies can metastasize to the gallbladder, renal cell carcinoma being a particularly common metastasizing tumor. Malignant Melanoma of the Gallbladder Pathogenic Pathways Few melanocytes are present in the normal gallbladder mucosa, and it has been suggested that malignant melanomas take their origin from these cells that have spread from the neural crest to the gallbladder during oncogenesis. Primitive Neuroectodermal Tumor (PNET) of the Gallbladder Differential Diagnosis Differential diagnosis on conventionally stained sections mainly includes other small cell tumors occurring in the gallbladder, e.g., small cell carcinoma or lymphoma. Differential Diagnosis Gallbladder paraganglioma may occur as a component of multiple paragangliomas, involving the common bile duct and the liver in addition to the gallbladder (Ferrell et al. 1990).

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Melanocytic, Neuroectodermal, Germ Cell, Rhabdoid, Perivascular Epithelioid Cell, Hemolymphatic, and Metastatic Tumors of the Gallbladder

Zimmermann

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Primary mucosa-associated lymphoid tissue lymphoma of the gallbladder: report of a case harboring API2/MALT1 gene fusion

Cited by 14 publications

References 13 publications

Incidental Presentation of Gall Bladder MALT Lymphoma

Incidental Presentation of Gall Bladder MALT Lymphoma

Melanocytic, Neuroectodermal, Germ Cell, Rhabdoid, Perivascular Epithelioid Cell, Hemolymphatic, and Metastatic Tumors of the Gallbladder

Melanocytic, Neuroectodermal, Germ Cell, Rhabdoid, Perivascular Epithelioid Cell, Hemolymphatic, and Metastatic Tumors of the Gallbladder

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