Primary mucinous carcinoma of the skin on the breast with lymph node metastasis

Mizutani, Kazuhiro; Taira, Mariko; Akiyama, Masashi

doi:10.1111/1346-8138.12556

Cited by 2 publications

(3 citation statements)

References 5 publications

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“…The absence of cancerous tissue in the nipple and posterior glands confirmed this finding. Similar to this finding, Mizutani et al [ 23 ] reported a rare case of cutaneous mucinous adenocarcinoma in a 78-year-old man. In the fourth year of follow-up review after prostate cancer treatment, an abnormally enlarged axillary lymph node (10 mm) was found, and a whole-body examination revealed the presence of a 30-mm-sized mass in the patient’s inner upper right chest.…”

Section: Discussionsupporting

confidence: 75%

“…In the fourth year of follow-up review after prostate cancer treatment, an abnormally enlarged axillary lymph node (10 mm) was found, and a whole-body examination revealed the presence of a 30-mm-sized mass in the patient’s inner upper right chest. For several years, the patient complained of a mass in the right chest but did not pay close attention to it; eventually, the mass was surgically excised as a benign 1-cm margin plus axillary lymph node dissection, and no breast tissue was found in the pathological specimen, but the enlarged axillary lymph node, which was the patient’s chief complaint, demonstrated mucinous adenocarcinoma metastasis[ 23 ]. This led to the following conclusions: (1) Mucinous tumors are easily missed; and (2) The incidence of axillary lymph node metastases of chest mucinous tumors is higher than that anticipated.…”

Section: Discussionmentioning

confidence: 99%

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Non-retroareolar male mucinous breast cancer without gynecomastia development in an elderly man: A case report

Sun,

Liu,

Zhang

et al. 2023

World J Clin Cases

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Insulin, a small protein with 51 amino acids synthesized by pancreatic β-cells, is crucial to sustain glucose homeostasis at biochemical and molecular levels. Numerous metabolic dysfunctions are related to insulin-mediated altered glucose homeostasis. One of the significant pathophysiological conditions linked to the insulin associated disorder is diabetes mellitus (DM) (type 1, type 2, and gestational). Insulin resistance (IR) is one of the major underlying causes of metabolic disorders despite its association with several physiological conditions. Metabolic syndrome (MS) is another pathophysiological condition that is associated with IR, hypertension, and obesity. Further, several other pathophysiological disorders/diseases are associated with the insulin malfunctioning, which include polycystic ovary syndrome, neuronal disorders, and cancer. Insulinomas are an uncommon type of pancreatic β-cell-derived neuroendocrine tumor that makes up 2% of all pancreatic neoplasms. Literature revealed that different biochemical events, molecular signaling pathways, microRNAs, and microbiota act as connecting links between insulin disorder and associated pathophysiology such as DM, insuloma, neurological disorder, MS, and cancer. In this review, we focus on the insulin-related disorders and the underlying mechanisms associated with the pathophysiology.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Non-retroareolar male mucinous breast cancer without gynecomastia development in an elderly man: A case report

Sun,

Liu,

Zhang

et al. 2023

World J Clin Cases

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“…Rarely, other body sites such as the earlobe, hand, vulva, buccal space, scrotum, and skin of the breast may be involved. [21][22][23] Bilateral eyelid tumors have also been described. 21 The tumor usually seems as an asymptomatic slow-growing nodule, but may also present as a cyst or ulcer.…”

Section: Discussionmentioning

confidence: 99%

Primary Mucinous Carcinoma of Skin: A Rare Cutaneous Neoplasm. Clinicopathologic Features, Differential Diagnoses, and Review of Literature

Tinguria

2023

The American Journal of Dermatopathology

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Primary mucinous carcinoma of the skin (PMCS) is a rare malignant neoplasm of sweat gland origin, with an incidence of 0.07 per million. Histologically, it may be difficult to differentiate it from metastatic mucinous carcinomas of the skin. A case of PMCS is reported here in a 59-year-old woman who presented with a lesion on the right lower eyelid. Histological examination revealed features of mucinous adenocarcinoma. The main differential diagnosis was metastatic mucinous adenocarcinoma; however, the lack of colorectal and lung markers and the presence of focal in situ components were consistent with the diagnosis of PMCS. PMCS and breast mucinous carcinoma share immunohistochemical markers, such as GCDFP-15 and mammaglobin; however, focal in situ component with the presence of myoepithelial cells in the tumor ruled out metastatic mucinous carcinoma of breast origin. The subsequent mammograms did not reveal any breast lesions. Colonoscopy did not show any evidence of colonic malignancy, and imaging studies (CT scan) did not show any evidence of neoplasm in the body. These findings were in keeping with a diagnosis of PMCS. The present case emphasizes the importance of clinicopathological correlation, histopathology, and immunohistochemistry in the accurate diagnosis of PMCS and summarizes the literature on these rare cutaneous neoplasms.

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Primary mucinous carcinoma of the skin on the breast with lymph node metastasis

Cited by 2 publications

References 5 publications

Non-retroareolar male mucinous breast cancer without gynecomastia development in an elderly man: A case report

Non-retroareolar male mucinous breast cancer without gynecomastia development in an elderly man: A case report

Primary Mucinous Carcinoma of Skin: A Rare Cutaneous Neoplasm. Clinicopathologic Features, Differential Diagnoses, and Review of Literature

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