Primary mucinous carcinoma of the skin with metastases to the lymph nodes

Pilgrim, J. P.; Kloss, Suni G.; Wolfish, P. S.; Heng, Ming K.

doi:10.1097/00000372-198510000-00011

Cited by 46 publications

(32 citation statements)

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“…20 The high incidence of local recurrence necessitates surgical excision with generous margins and exploration of regional lymph nodes if warranted. 17 This point is highlighted by our case as the patient required 3 wide excisions to achieve complete resection. Some authors have speculated that the high degree of differentiation and copious amounts of mucin found in this tumor are related to its low incidence of metastasis.…”

Section: Discussionmentioning

confidence: 77%

“…7,11,12,14,16,20,23 The primary lesion of MCS is usually a solitary, subcentimeter nodule with a characteristic slow growth rate; the lesion may be present for 20 years before the patient seeks medical attention. 2,17 The clinical presentation of MCS lesions is not characteristic and varies in appearance, from pinkish tan to gray, red or blue. 7 The clinical differential diagnosis is broad and includes epidermal inclusion cyst, lipoma, hemangioma, cystic basal cell carcinoma, melanoma and squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…7 The clinical differential diagnosis is broad and includes epidermal inclusion cyst, lipoma, hemangioma, cystic basal cell carcinoma, melanoma and squamous cell carcinoma. 17,23 Once the pathologic diagnosis of mucinous carcinoma is considered, it is of utmost importance to rule out metastases from other sites. In this case, based on the cytomorphology, metastatic breast and colonic adenocarcinoma are possible considerations in the differential diagnoses.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors have speculated that the high degree of differentiation and copious amounts of mucin found in this tumor are related to its low incidence of metastasis. 4,17 In the rare cases of metastatic disease, the metastases are highly resistant to radiotherapy and chemotherapy. 11,23 In our case, a single micrometastasis was found in a sentinel lymph node.…”

Section: Discussionmentioning

confidence: 99%

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Fine Needle Aspiration Biopsy of Primary Mucinous Carcinoma of the Skin

Reid-Nicholson¹,

Iyengar²,

Friedlander³

et al. 2006

Acta Cytologica

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Fine Needle Aspiration Biopsy of Primary Mucinous Carcinoma of the Skin

Reid-Nicholson¹,

Iyengar²,

Friedlander³

et al. 2006

Acta Cytologica

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“…The individual tumor cells manifest hyperchromatic nuclei with nucleolation and a degree of cytologic atypia which varies from low grade to frankly anaplastic (Figures 13 and 14). [155][156][157][158][159][160][161][162][163] Cytoplasms are vacuolated and may show signet ring formation with peripheral displacement of the nucleus by a large intracytoplasmic vacuole. Pools of mucin dissect the stroma, creating rounded and irregularly shaped aggregates of PAS-positive, diastase-resistant material which decorates with Alcian blue or with Hale's colloidal iron.…”

Section: Histopathologymentioning

confidence: 99%

Malignant adnexal neoplasms

2006

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Malignant cutaneous adnexal neoplasms are one of the most challenging areas of dermatopathology. Tumors of the pilosebaceous apparatus can occur as single-lineage neoplasms or may manifest as complex proliferations with multilineal differentiation patterns including not only the germinative component of the hair bulb, the inner or outer root sheath epithelium and the sebaceous gland and duct, but also the sweat duct components that relate to the apocrine secretory apparatus which empties into the follicle near the follicular bulge. Eccrine and apocrine neoplasms present a bewildering array of morphologies, which often defy precise classification. The purpose of this review is to discuss in detail the malignant neoplasms of the cutaneous adnexae and their benign and prognostically indeterminate mimics. Modern Pathology (2006) 19, S93-S126. doi:10.1038/modpathol.3800511Keywords: eccrine carcinoma; sebaceous neoplasia Malignant tumors of the pilosebaceous apparatus, their mimics and precursors IntroductionTumors of the pilosebaceous unit can occur in isolation or in combination with complex proliferations showing multilineal differentiation patterns encompassing those of sweat ducts, epidermis and stroma with its varied components. In this review, we will focus upon the malignant adnexal proliferations, considering benign entities mainly insofar as they impact the diagnostic approach to adnexal carcinoma. We will first turn to the malignant sebaceous neoplasms, their precursors and their mimics. Sebaceous adenoma Clinical FeaturesThe sebaceous adenoma is a benign neoplasm that manifests clinically as a pale yellow nodular lesion, typically of the face, that expresses itself clinically after the age of 50. Tumors range in size from o1 to 45 cm. [1][2][3][4][5][6] These lesions are associated with the Muir-Torre syndrome, comprising the coexpression of cutaneous neoplasms, including those of sebaceous type with well-differentiated squamous epithelial neoplasms, and visceral malignancies, including carcinomas of the breast, ovary, gastrointestinal tract and larynx. [7][8][9][10][11][12][13][14] An occasional patient may manifest a malignant lymphoma of nodal or extranodal type. 10,12,14 Sebaceous neoplasms in the setting of Muir-Torre syndrome are often difficult to classify, showing overlap features between all of the prototypic forms of sebaceous neoplasm ranging from hyperplasia to carcinoma. 13 HistologyThe prototypic sebaceous adenoma manifests 1-2 layers of germinitive cells which mature to form central sebocytes, and have an architecture comprising a sharply circumscribed sebaceous lobule surrounded by a compressed pseudocapsule of dermal stroma ( Figure 1a). The overlying epidermis may be attenuated, but sometimes forms a collarette around the peripheral aspect of the neoplasm. Unlike sebaceous hyperplasia, occasional mitoses may be seen in the lobules of a sebaceous adenoma and in concert with this nucleoli may be somewhat prominent, but the pleomorphism, hyperchromasia and individual cell necrosis of the se...

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