Primary Mucinous Adenocarcinoma of the Vagina

Ebrahim, Shamim; Daponte, Alexandros; Smith, Trudy; Tiltman, A. J.; Guidozzi, F

doi:10.1006/gyno.2000.5963

Cited by 16 publications

(5 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vaginal adenocarcinomas are much less common, constituting about 5% to 15% of all vaginal carcinomas (1)(2)(3). Most adenocarcinomas involving the vagina are metastases from other organs, such as uterus, ovary, breast, and gastrointestinal tract (1,9,10). Our patient did not have a tumor in any organs or tissues other than the vagina.…”

Section: Discussionmentioning

confidence: 58%

See 1 more Smart Citation

Adenocarcinoma Arising from Vaginal Stump

Shibata

Iwai²,

Tokuda³

et al. 2013

International Journal of Gynecological Pathology

View full text Add to dashboard Cite

Primary vaginal adenocarcinomas are one of the rarest malignant neoplasms, which develop in the female genital tract. Because of the extremely low incidence, their clinical and pathologic characteristics are still obscure. Recently, we experienced a case of vaginal adenocarcinoma that appeared 7 yr after hysterectomy because of cervical intraepithelial neoplasia. The patient, a 65-yr-old obese woman, was diagnosed as having adenocarcinoma in the vaginal stump and was treated by simple tumor excision and radiation. Immunohistochemical and molecular biologic examinations indicated a potential association with human papilloma virus infection in the development of the vaginal adenocarcinoma. There has been no evidence of recurrence for 3 yr after the operation.

show abstract

Section: Discussionmentioning

confidence: 58%

“…Interestingly, a certain proportion of patients with vaginal adenocarcinoma had a preceding hysterectomy (3,(9)(10)(11)13,15). The hysterectomies were performed not only for the malignant neoplasms but also for the benign lesions.…”

Section: Discussionmentioning

confidence: 99%

Adenocarcinoma Arising from Vaginal Stump

Shibata

Iwai²,

Tokuda³

et al. 2013

International Journal of Gynecological Pathology

View full text Add to dashboard Cite

show abstract

“…39 There are several types of vaginal adenocarcinoma reported, including clear-cell, serous and mucinous types. [40][41][42] The histogenesis of primary vaginal adenocarcinoma, particularly which is not associated with in utero diethylstilboestrol exposure, 43 is not well understood. The current results suggest a contribution of the Pten/Akt/mTOR signaling pathway to the aforementioned histogenesis; in particular, the vaginal mucinous adenocarcinoma might be involved in MAPK signaling cascade as well.…”

Section: Discussionmentioning

confidence: 99%

Unique roles of estrogen-dependent Pten control in epithelial cell homeostasis of mouse vagina

et al. 2014

View full text Add to dashboard Cite

Numerous studies support a role of phosphatase and tensin homolog deleted from chromosome 10 (Pten) as a tumor suppressor gene that controls epithelial cell homeostasis to prevent tumor formation. Mouse vaginal epithelium cyclically exhibits cell proliferation and differentiation in response to estrogen and provides a unique model for analyzing homeostasis of stratified squamous epithelia. We analyzed vaginal epithelium-specific Pten conditional knockout (CKO) mice to provide new insights into Pten/phosphoinositide-3-kinase (PI3K)/Akt function. The vaginal epithelium of ovariectomized (OVX) mice (control) was composed of 1-2 layers of cuboidal cells, whereas OVX CKO mice exhibited epithelial hyperplasia in the suprabasal cells with increased cell mass and mucin production. This is possibly due to misactivation of mammalian target of rapamycin and mitogen-activated protein kinase. Intriguingly, estrogen administration to OVX Pten CKO mice induced stratification and keratinized differentiation in the vaginal epithelium, as in estrogen-treated controls. We found that Pten is exclusively expressed in the suprabasal cells in the absence of estrogens, whereas estrogen administration induced Pten expression in the basal cells. This suggests that Pten acts to prevent excessive cell proliferation as in the case of other squamous tissues. Thus, Pten exhibits a dual role on the control of vaginal homeostasis, depending on whether estrogens are present or absent. Our results provide new insights into how Pten functions in tissue homeostasis.

show abstract

“…[9,10] Embrahim S et al commented that as primary mucinous adenocarcinoma of the vagina is rare tumor individualized treatment is justified until larger series have been published. [11] Primary mucinous adenocarcinoma of vagina is characterized by aggressiveness and poor prognosis because of its rapid growth and recurrence, its frequent distant metastases, and its relative resistance to conventional treatment modalities including surgery, radiotherapy and chemotherapy. [12] Diagnosis of primary clear cell adenocarcinoma of vagina should be based on normal cytopathologic examination of the cervix, endometrium, uterus, ovaries, kidneys and absence of detectable tumor in urinary tract.…”

Section: Discussionmentioning

confidence: 99%