Primary midbrain germinoma

Kalra, Samir Kumar; Vaıd, Vivek Kumar; Jaiswal, Awadhesh Kumar; Behari, Sanjay; Jain, Vibha; Kumari, Niraj

doi:10.1016/j.jocn.2007.07.079

Cited by 10 publications

(8 citation statements)

References 10 publications

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“…As spinal seedling is rare with ectopic germinomas, prophylactic spinal irradiation does not provide any additional benefit. [ 2 ]…”

Section: Discussionmentioning

confidence: 99%

“…As spinal seedling is rare with ectopic germinomas, prophylactic spinal irradiation does not provide any additional benefit. [2] Chemotherapy has also been tried in intracranial germinomas. [3,7,13,16] Similar to the extracranial germinomas, bleomycin, etoposide, cisplatin, vinblastine regimen is popular among those who use it.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 ] Off-midline intracranial GCTs, often known as ectopic GCTs, are very rare and may be located in the basal ganglia, the thalamus, the spinal cord, the corpus callosum, or the fourth ventricle. [ 2 ] Germinoma located in the basal ganglia-thalamus complex is an extremely rare occurrence. The incidence of basal ganglionic GCTs (BGGCTs) is estimated to be 10%–18.8%.…”

Section: Introductionmentioning

confidence: 99%

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Capsuloganglionic germinoma: A rare site for uncommon childhood tumor

et al. 2018

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Germ cell tumors (GCTs) are rare intracranial tumors with a strong predilection for children. Commonly, these tumors arise either in the suprasellar or the pineal region. The basal ganglia-thalamus complex represents a rare site of nonmidline intracranial GCTs. Such basal ganglionic GCTs have been reported to produce certain interesting clinico-radiological features, the knowledge of which may provide important diagnostic clues preoperatively. We present the case of a 9.5-year-old boy who presented with right hemiparesis and precocious puberty. Imaging revealed a heterogeneously enhancing mass involving the left capsuloganglionic region, sparing the thalamus. There was little perilesional edema and midline shift. Because of the deep location of the mass and a lack of mass effect, a neuronavigation-guided tumor biopsy was performed which unraveled a pure germinoma. The child was referred for adjuvant radiotherapy following an uneventful postoperative course. At the time of writing the report, the child was on radiotherapy and doing well.

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“…As spinal seedling is rare with ectopic germinomas, prophylactic spinal irradiation does not provide any additional benefit. [ 2 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Capsuloganglionic germinoma: A rare site for uncommon childhood tumor

et al. 2018

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“…The germ cell theory hypothesizes malignant transformation of mis-migrational primordial germ cells. [31011] The embryonic theory, in contrast, suggests that these tumors arise from mis-migrational pluripotent germ cells. [312] GCT constitutes nearly 2[45] to 3% of pediatric brain tumors, with 85% of them occurring before the second decade of life.…”

Section: Discussionmentioning

confidence: 99%

Primary intracranial germ cell tumors

Mufti

Jamal

2012

Asian J Neurosurg

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Background:Primary intracranial germ cell tumors are rare (ICGCTs) and usually localized in the pineal and suprasellar regions of the brain. They are divided into histologic types: Germinoma, teratoma choriocarcinoma, embryonal carcinoma, yolk sac tumor, and malignant mixed germ cell tumors (MMGCTs). Neuroimaging evaluation is useful to distinguish between the types of ICGCTs. Germinoma is highly sensitive to radiotherapy or/and chemotherapy, and is potentially curable without surgery. MMGCTs are treated with the combination of chemotherapy and radiation, with a poorer prognosis. ICGCTs warrant correct pre-operative diagnosis in order to decide on appropriate management.Aim:To report the clinicopathological and immunohistochemical findings in three cases of primary intracranial germ-cell tumor.Materials and Methods:Three cases of intracranial germ cell tumors inclusive of both genders and all brain regions were retrieved from the archives of the Anatomical Pathology Department at King Abdul Aziz University Hospital, Jeddah between the years, 1995-2011, through a computerized search.Results:Based on histological examination, they were respectively diagnosed as MMGCTs (two cases) and germinoma. Clinical, radiological, pathological characteristics and immunohistochemical profile of the three ICGCTs are presented along with the review of recent literature.Conclusion:ICGCTs are rare tumors affecting males more than females, and at the end of three years follow-up in the present study, treatment morbidity appears to be low with no recurrence observed among surviving patients, indicating that suprasellar and basal ganglia ICGCTs may have a favorable prognosis regardless of histological type. Pineal MMGCTs may have an aggressive course.

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“…CNS GCTs usually originate in the suprasellar and pineal regions. Less frequently, non-midline intracranial structures, including the basal ganglia and thalami may appear, and rarely the tumor may arise primarily in the spinal cord or the cerebellum (115)(116)(117)(118)(119). Males have an overall higher incidence of CNS GCTs than females.…”

Section: Gcts and Differential Diagnosis In The Sellar Region And Pineal Glandmentioning

confidence: 99%

Imaging of brain tumors in children: the basics—a narrative review

Resende

Alves

2021

Transl Pediatr

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Childhood CNS cancer was also the top reason for cancer mortality in children in 2009 (2).Unlike neoplasms in other locations, primary brain tumors are not staged, but categorized according to the World Health Organization (WHO) 2016 Classification, which relies on molecular parameters in addition to histology to define their entities (3). Our goal is to offer an overview of these tumors, describing the imaging characteristics of the most common primary brain tumors in children based on the WHO classification update. We present the following article in accordance with the Narrative Review reporting checklist (http://dx.doi.

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Primary midbrain germinoma

Cited by 10 publications

References 10 publications

Capsuloganglionic germinoma: A rare site for uncommon childhood tumor

Capsuloganglionic germinoma: A rare site for uncommon childhood tumor

Primary intracranial germ cell tumors

Imaging of brain tumors in children: the basics—a narrative review

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