Primary Mesenteric Sertoli-Leydig Cell Tumor: A Case Report and Review of the Literature

Trabelsi, Amel; Abdelkarim, Soumaya Ben; Hadfi, Mohamed; Fatnaci, Ridha; Stita, Wided; Sriha, Badreddine; Korbi, S.

doi:10.1155/2008/619637

Cited by 9 publications

(17 citation statements)

References 11 publications

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“…The commonest extra ovarian primary sex cord tumours reported in literature is granulosa cell tumour. 12 In 2008 Trabelsi et al reported the first case of primary mesenteric sertoli Leydig cell tumour. 12 Naniwadekar et al in 2010 also reported an extra ovarian granulosa cell tumour in mesentery.…”

Section: 45mentioning

confidence: 99%

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Extra gonadal sclerosing stromal tumour in the transverse mesocolon

Mensah¹,

Kyei²,

Ohene-Yeboah³

et al. 2016

Ghana Medical Journal

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SUMMARYSclerosing stromal tumour (SST) is a rare benign sex cord stromal tumour of the ovary. We report a case of sclerosing stromal tumour of the mesentery in a 32-year-old Para one who presented with intra abdominal mass, menstrual irregularity and secondary infertility. Histopathology and immunohistochemistry of the completely excised tumour was consistent with sclerosing stromal tumour, immunoreactive only to vimentin. No ovarian tissue was found in the sectioned tumour. Her menses became regular and she conceived 3 months after complete excision and delivered after 9 months. Hormonal assay was not done because SST was least suspected. From literature this is the first case of SST in the transverse mesocolon reported in the West African subregion, and may probably be one of the rare cases of hormonally active SST.

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Section: 45mentioning

confidence: 99%

“…12 In 2008 Trabelsi et al reported the first case of primary mesenteric sertoli Leydig cell tumour. 12 Naniwadekar et al in 2010 also reported an extra ovarian granulosa cell tumour in mesentery. 13 In 2013, Moktari et al published the first case of sclerosing stromal tumour in an extra ovarian location; between the bladder and the uterus.…”

Section: 45mentioning

confidence: 99%

Extra gonadal sclerosing stromal tumour in the transverse mesocolon

Mensah¹,

Kyei²,

Ohene-Yeboah³

et al. 2016

Ghana Medical Journal

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“…Sertoli-Leydig cell tumors (SLCTs) are rare ovarian tumors that belong to the group of sex-cord stromal tumors, comprising less than 0.5% of ovarian neoplasms, and mainly occur in young adult women in their 20s [1]. The occurrence of primary sex-cord stromal tumors at heterotopic extraovarian sites is exceptionally rare [2, 3]. Many heterotopic extraovarian sex-cord stromal tumors occur in the broad ligament and retroperitoneum, and these histological types are granulosa cell tumors [2, 3].…”

Section: Introductionmentioning

confidence: 99%

“…The occurrence of primary sex-cord stromal tumors at heterotopic extraovarian sites is exceptionally rare [2, 3]. Many heterotopic extraovarian sex-cord stromal tumors occur in the broad ligament and retroperitoneum, and these histological types are granulosa cell tumors [2, 3]. To the best of our knowledge, only one case of primary mesenteric SLCT has been reported [3].…”

Section: Introductionmentioning

confidence: 99%

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Mesenteric extraovarian Sertoli-Leydig cell tumor without DICER1 hotspot mutation: a case report

et al. 2019

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Background Ovarian Sertoli-Leydig cell tumors (SLCTs) with androgenic manifestations harbor DICER1 mutations in 30–60% of cases. Ovarian SLCTs without DICER1 hotspot mutations have been reported to exhibit elderly onset and no androgenic manifestations. We present the first case of a primary mesenteric SLCT without DICER1 hotspot mutation. Case presentation An 84-year-old woman presented with a 75-mm mesenteric solid tumor. She presented no androgenic or estrogenic manifestations. She underwent ileocecal resection. Histologically, her mesenteric tumor showed histopathological features that resembled moderately differentiated SLCT. Moreover, DICER1 hotspot mutation was not detected. Conclusions We described the first case of heterotopic primary mesenteric SLCT without DICER1 hotspot mutation.

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Thoracic Sertoli–Leydig cell tumor: An alternative type of pleuropulmonary blastoma associated with DICER1 variation

Terry

Carlisle

Mallinger

et al. 2021

Pediatric Blood & Cancer

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A 2‐year‐old boy presented with a large cystic and solid chest mass arising from the lung, radiographically consistent with pleuropulmonary blastoma (PPB). He underwent right lower lobectomy with resection of a well‐circumscribed, mixed solid and cystic mass. The solid areas were composed of cords and nests of tumor cells in the myxoid stroma and retiform foci whose pathologic and immunophenotypic findings were consistent with a sex cord‐stromal tumor with features of a Sertoli–Leydig cell tumor. Tumor testing showed a pathogenic variant in the DICER1 RNase IIIb hotspot domain. Family history was suggestive of DICER1 germline pathogenic DICER1 variation in absence of a detectable germline variant. He received 12 cycles of chemotherapy with ifosfamide, vincristine, dactinomycin and doxorubicin (IVADo) and surgery with complete response. One year after completion of chemotherapy, imaging studies showed concern for recurrence confirmed by thorascopic biopsy of a pleural‐based mass. He is currently receiving cisplatin‐based chemotherapy with reduction in tumor size. Review of the literature showed no similar cases; however, review of our pathology files revealed a single similar case of anterior mediastinal Sertoli cell tumor in a 3‐year‐old girl.

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Primary Mesenteric Sertoli-Leydig Cell Tumor: A Case Report and Review of the Literature

Cited by 9 publications

References 11 publications

Extra gonadal sclerosing stromal tumour in the transverse mesocolon

Extra gonadal sclerosing stromal tumour in the transverse mesocolon

Mesenteric extraovarian Sertoli-Leydig cell tumor without DICER1 hotspot mutation: a case report

Thoracic Sertoli–Leydig cell tumor: An alternative type of pleuropulmonary blastoma associated with DICER1 variation

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