Primary meningeal pheochromocytoma: case report

Mercuri, Sandro; Gazzeri, Roberto; Galarza, Marcelo; Esposito, Stefano; Giordano, Marco

doi:10.1007/s11060-004-4595-5

Cited by 9 publications

(9 citation statements)

References 19 publications

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“…have reported a meningeal pheochromocytoma that was discovered 23 years after the initial resection of the adrenal primary tumor. [8] By comparison, our patient had metastatic disease discovered 34 years after his last abdominal resection which represents the longest reported disease-free period prior to the discovery of metastatic disease in the literature. Given the long possible latency period between primary disease and discovery of metastasis or disease recurrence, long-term follow-up appears warranted.…”

Section: Discussionmentioning

confidence: 82%

“…[5] Only a few reports of intracranial metastasis for pheochromocytoma exist and to our knowledge, only two other cases of intracranial metastasis have been reported for paraganglioma. [4814] Although Zhang et al . have reported a single case of intraparenchymal involvement of metastatic disease from a paraganglioma, our patient and all other reports of intracranial metastasis demonstrated extra-axial lesions that often involved the skull table.…”

Section: Discussionmentioning

confidence: 99%

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Delayed intracranial and bony metastasis of paraganglioma

Yew

Kim²,

Chang³

et al. 2011

Surg Neurol Int

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Background:Paragangliomas are tumors of neural crest origin that arise from the extra-adrenal paraganglia. In contrast with the often quoted 10% rule of malignancy for pheochromocytomas, the rate of malignancy as defined by local invasion or distant metastasis has been reported to be from 20% to as high as 50% in some case series with the most common sites of distant metastases being the liver, lungs, and bones. Here we present the case of a patient who presented with a rare case of intracranial metastasis from abdominal paraganglioma.Case Description:Our patient was a 48-year-old male with a distant history of multiple resections of abdominal paraganglioma in 1975 who presented with left shoulder, and left occipital metastasis 35 years after his original paraganglioma operations.Conclusions:Intracranial metastasis of paraganglioma is rare. There are unfortunately no known criteria to assess the risk of metastatic potential and given the long possible latency period between the resection of the primary tumor and the discovery of metastatic disease, patients with paragangliomas require lifelong monitoring. The optimal interval of monitoring has not been elucidated but follow-up every 5–10 years seems warranted.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Delayed intracranial and bony metastasis of paraganglioma

Yew

Kim²,

Chang³

et al. 2011

Surg Neurol Int

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“…Mercuri et al reported a primary meningeal pheochromocytoma that presented with headache, vomitting, and arterial hypertension. (19) Laboratory studies revealed high plasma catecholamines (norepinephrine and epinephrine). The tumor was resected, and histopathological examination confirmed the diagnosis.…”

Section: Intracranial Pheochromocytomamentioning

confidence: 99%

Headache in Pheochromocytoma

Watanabe¹

2011

Pheochromocytoma - A New View of the Old Problem

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“…Pheochromocytomas are catecholamine-secreting tumors that arise from chromaffin cells of the adrenal medulla, though they may also arise as paraganglioma in the extra-adrenal sympathetic nervous system 1 . The reported incidence is approximately one case per 100 thousand person-years [2][3][4] . Only about 10% of pheochromocytomas are malignant, and the presence of metastasis is the only criterion for malignancy 2,4,5 .…”

Section: Introductionmentioning

confidence: 99%

“…The reported incidence is approximately one case per 100 thousand person-years [2][3][4] . Only about 10% of pheochromocytomas are malignant, and the presence of metastasis is the only criterion for malignancy 2,4,5 . The most common locations for metastasis include bone, liver, lymph node, lung 2,4,6 and spleen 7 .…”

Section: Introductionmentioning

confidence: 99%

Metastatic adrenal pheochromocytoma to the thoracic spine

2010

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To report on a case of pheochromocytoma metastases to the spine occurring more than 20 years after initial diagnosis. A 34-year-old female with a history of metastatic pheochromocytoma diagnosed at age 12 presented with weakness, heart palpitations, and circumferential back pain of five months duration. The patient had undergone multiple laparatomies for abdominal and hepatic metastases. Work-up revealed a destructive lesion at T9. After two weeks of preoperative phenoxybenzamine to control her hypertension, she underwent decompression, posterior fixation and fusion. Surgical intervention was followed by radiation therapy, zoledronic acid, and only one cycle of chemotherapy due to intolerance of side effects. The patient survived 25 years after original diagnosis, which far exceeds the average survival of less than 15 years. The patient died 26 months postoperatively due to progression of disease. Pheochromocytoma with spine metastases occurring more than 20 years after diagnosis is very uncommon, and should be considered in the differential diagnosis of a patient with a history of pheochromocytoma.

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Primary meningeal pheochromocytoma: case report

Abstract: To our knowledge this is the first reported case of a primary meningeal pheochromocytoma.

Cited by 9 publications

References 19 publications

Delayed intracranial and bony metastasis of paraganglioma

Delayed intracranial and bony metastasis of paraganglioma

Headache in Pheochromocytoma

Metastatic adrenal pheochromocytoma to the thoracic spine

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