Primary meningeal NK/T cell lymphoma masquerading as tuberculous meningitis

Cai, Bin; Hu, Jianhe; Tang, Qing-Xi; Lin, Wei; Wang, Ning

doi:10.1007/s10072-014-1783-8

Cited by 5 publications

(6 citation statements)

References 5 publications

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“…than extracranial NK/TCL. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] PCNSLs are often accompanied by nonspecific clinical symptoms such as dizziness, headache, vomiting, and blurred vision. Our patient presented with loss of visual acuity and weakness of the limbs, which were consistent with the nonspecific symptoms of primary CNS lymphoma.…”

Section: Discussionmentioning

confidence: 99%

“…collected from the English literature and summarized. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] These patients were pathologically diagnosed as primary CNS ENK/TCL, excluding secondary and invasive NK cell leukemia. According to previously reported cases, overall survival in patients with PCNS ENK/TCL is not high.…”

Section: Discussionmentioning

confidence: 99%

“…The highest survival reported was 139 months to date, and the median overall survival was 6 months. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] There were nineteen immunocompetent (IC) cases and two immunosuppressive (IS) cases of which one was infected with HIV and the another was a posttransplant patient. Most of the patients were from Asia, Africa, and Spain, and the age of these patients was between 13 and 77 years (median, 53 years).…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, only 23 cases of PCNS ENK/TCL have been reported in the English literature. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] To date, the understanding of this tumor is not deep enough. Herein, we present a case of PCNS ENK/TCL in a 50year-old immunocompetent Chinese female and review of the literature.…”

Section: Introductionmentioning

confidence: 99%

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Successful Treatment of Primary CNS Extranodal NK/T-Cell Lymphoma with Surgery and Chemotherapy Combined with Sintilimab: A Case Report and Literature Review

Qin¹,

Li²,

He³

et al. 2022

OTT

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Primary central nervous system extranodal natural killer/T-cell lymphoma (PCNS ENK/TCL) is an extremely rare lymphoma. Only 23 cases of PCNS ENK/TCL have been reported in the English literature. Due to the rarity of this lymphoma, an effective therapeutic strategy has not been defined. Generally, this type of lymphoma is treated with surgery, intrathecal chemotherapy, and postoperative chemoradiation therapy. The prognosis is poor. Herein, we present a case of primary brain NK/T cell lymphoma in a 50-year-old immunocompetent Chinese female and review the literature. The patient underwent intracranial tumor resection and was subsequently treated with a PD1 monoclonal antibody (Sintilimab) combined with chemotherapy. The patient survived 15 months after diagnosis. This is the first report of PCNS ENK/TCL treated with surgery and chemotherapy combined with immunotherapy and suggests an effective treatment regimen for PCNS ENK/TCL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Successful Treatment of Primary CNS Extranodal NK/T-Cell Lymphoma with Surgery and Chemotherapy Combined with Sintilimab: A Case Report and Literature Review

Qin¹,

Li²,

He³

et al. 2022

OTT

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“…Extranodal NK/T‐cell lymphoma, nasal type (ENKTCL), is an aggressive tumor that almost always shows extranodal involvement and is characterized by intermediate‐sized tumor cells, vascular destruction, prominent necrosis, a cytotoxic phenotype, and an association with Epstein–Barr virus (EBV). PCNS ENKTCL is extremely rare, to our knowledge, with only 27 cases reported in the literature 3–25 …”

Section: Introductionmentioning

confidence: 98%

Primary central nervous system extranodal NK/T‐cell lymphoma, nasal type with CD20 expression: Case report and review of the literature

Guan,

Lin,

Liu

et al. 2023

Neuropathology

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Primary central nervous system (PCNS) extranodal NK/T‐cell lymphoma, nasal type (ENKTCL), is an exceedingly rare tumor. To the best of our knowledge, only 27 cases and only one reported aberrant CD20 expression have been documented in the literature. Here we present a second case of PCNS ENKTCL with aberrant CD20 expression in a 43‐year‐old immunocompetent Chinese female. The patient presented with tremors, weakness in the right upper limb, and a slow reaction. Magnetic resonance imaging revealed multiple brain lesions. A histological examination revealed a diffuse distribution of intermediate‐sized pleomorphic lymphocytes with angiocentric growth. The tumor cells expressed CD2, CD3, CD56, T‐cell intracellular antigen‐1, granzyme B, and Epstein–Barr virus‐encoded RNAs (EBERs), with additional partial and weak CD20 and CD30 expression. Despite a confirmatory pathological diagnosis, the patient refused treatment and was discharged, ultimately dying from the disease. In the literature review, the clinical, immunohistochemical, EBERs, treatment, and prognostic features of PCNS ENKTCL were summarized. Although PCNS ENKTCT is extremely rare, it does occur and should always be included in differential diagnoses. CD20 expression should be evaluated routinely with relevant markers. The accumulation of cases is crucial for developing an effective treatment strategy for this rare and aggressive malignancy.

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Extranodal NK/T Cell Lymphoma, Nasal Type (ENKTL-NT): An Update on Epidemiology, Clinical Presentation, and Natural History in North American and European Cases

Haverkos

Pan

Gru

et al. 2016

Curr Hematol Malig Rep

159

222

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Extranodal NK/T-cell lymphoma, nasal type (ENKTL-NT) is an aggressive extranodal non-Hodgkin lymphoma most commonly occurring in East Asia and Latin America but with increasing incidence in the U.S. Data on epidemiology, disease presentation, and outcome for European and North American (“Western”) cases are very limited. We review published landmark clinical studies on ENKTL-NT in the West and report in detail recent data, including our institutional experience. We highlight key observations in its epidemiology, natural history, and trends in clinical management. In the U.S., ENKTL-NT is more common among Asian Pacific Islanders (API) and Hispanics compared to non-Hispanic whites. Published studies indicate less heterogeneity in clinical presentation in Western ENKTL-NT compared to Asian patients. While there is variation in age at diagnosis, presence of antecedent lymphoproliferative disorders, and outcomes among racial/ethnic groups, the universal association of ENKTL-NT with EBV and the poor response of this neoplasm to anthracycline-based therapy are consistent across all geographic areas.

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Primary meningeal NK/T cell lymphoma masquerading as tuberculous meningitis

Cited by 5 publications

References 5 publications

Successful Treatment of Primary CNS Extranodal NK/T-Cell Lymphoma with Surgery and Chemotherapy Combined with Sintilimab: A Case Report and Literature Review

Successful Treatment of Primary CNS Extranodal NK/T-Cell Lymphoma with Surgery and Chemotherapy Combined with Sintilimab: A Case Report and Literature Review

Primary central nervous system extranodal NK/T‐cell lymphoma, nasal type with CD20 expression: Case report and review of the literature

Extranodal NK/T Cell Lymphoma, Nasal Type (ENKTL-NT): An Update on Epidemiology, Clinical Presentation, and Natural History in North American and European Cases

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