Primary Membranous Glomerulonephritis: The Role of Serum and Urine Biomarkers in Patient Management

Maifata, Sadiq Mu'azu; Hod, Rafidah; Zakaria, Nor Fadhlina; Ghani, Fauzah Abd

doi:10.3390/biomedicines7040086

Cited by 13 publications

(13 citation statements)

References 107 publications

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“…Patients may undergo a Biomolecules 2020, 10, 319 2 of 14 series of renal biopsy to diagnose and monitor the disease condition. The discovery of anti-PLA 2 R Ab [5] in the serum of primary MGN patients and anti-THSD7A Ab [6] among primary MGN variants who are seronegative for anti-PLA 2 R Ab changes the dimension of diagnosis monitoring of patients using different techniques like western blot, recombinant immunofluorescence, enzyme-linked immunosorbent assay (ELISA) and many others [7]. Several studies suggested that anti-PLA 2 R Ab could be used as a prognostic biomarker for primary MGN and thus, used in monitoring primary MGN patients [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies suggested that anti-PLA 2 R Ab could be used as a prognostic biomarker for primary MGN and thus, used in monitoring primary MGN patients [8,9]. In addition, most studies supported the use of ELISA as a technique of choice for the detection of biomarkers (anti-PLA 2 R and anti-THSD7A) based on the following reasons: high sensitivity and specificity, ability to measure both qualitative and quantitative assays and affordability [7,10]. Despite all this progress mentioned on serum anti-PLA 2 R Ab and anti-THSD7A Ab above, urine anti-PLA 2 R and anti-THSD7A are lacking [7,11].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, most studies supported the use of ELISA as a technique of choice for the detection of biomarkers (anti-PLA 2 R and anti-THSD7A) based on the following reasons: high sensitivity and specificity, ability to measure both qualitative and quantitative assays and affordability [7,10]. Despite all this progress mentioned on serum anti-PLA 2 R Ab and anti-THSD7A Ab above, urine anti-PLA 2 R and anti-THSD7A are lacking [7,11]. This study contributes to highlighting the role of these serum and urine biomarkers in early diagnosis, treatment decision, monitoring and prognostication of primary MGN patients.…”

Section: Introductionmentioning

confidence: 99%

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RETRACTED: Role of Serum and Urine Biomarkers (PLA2R and THSD7A) in Diagnosis, Monitoring and Prognostication of Primary Membranous Glomerulonephritis

et al. 2020

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Differentiating primary and secondary membranous glomerulonephritis (MGN) using biomarkers for MGN is essential in patients’ diagnosis, treatment and follow-up. Although biopsy has been the primary tool in making the diagnosis, not all patients can withstand it due to its invasive nature, and it cannot be used to monitor treatment. Hence, there is the need for less invasive or even non-invasive biomarkers for effective diagnosis, treatment monitoring and prognostication. This study aimed at providing an alternative way of differentiating primary and secondary MGN using enzyme-linked immunosorbent assay (ELISA) technique for serum and urine biomarkers (M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A)) for prompt diagnosis, treatment and prognosis. A total of 125 subjects, including 81 primary and 44 secondary MGN subjects, were diagnosed from January 2012 to October 2019 at Hospital Serdang and Hospital Kuala Lumpur from which 69 subjects consisting of 47 primary and 22 secondary MGN subjects participated in the study. Of these, 13 primary MGN subjects were positive for both serum and urine anti-PLA2R antibodies (Ab) whereas only one secondary MGN subject associated with hepatitis B virus was positive for both serum and urine anti-PLA2R Ab. At the same time, anti-THSD7A Ab was found positive in four primary MGN subjects and two secondary MGN subjects with malignancy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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RETRACTED: Role of Serum and Urine Biomarkers (PLA2R and THSD7A) in Diagnosis, Monitoring and Prognostication of Primary Membranous Glomerulonephritis

et al. 2020

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“…Like other studies (18,20), this study also demonstrated that nephrotic syndrome was the most common presentation among adults with MGN. Haematuria was also a common presentation, especially among individuals with the nephritic-nephrotic syndrome (21)(22)(23), while hypertension was seen mostly as a complication when there is renal compromise or in the acute form of MGN, occurring in up to 30% of cases (9,22) similar as in this study where it was reported in 37.6% of subjects with primary MGN.…”

Section: General Characteristics Of the Subjectssupporting

confidence: 69%

Membranous Glomerulonephritis: A Retrospective Study on Prognostic Outcome

Maifata¹,

Ghani²,

Hod³

et al. 2022

Preprint

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Background: Membranous glomerulonephritis (MGN) is one of the most common causes of nephrotic syndrome in non-diabetic adults, accounting for up to one-third of biopsy diagnostics in some regions. A watchful waiting strategy has been adopted to accurately assess the success of MGN. In this study, we predict prognostic risk factors for primary MGN patients for effective intervention and prognosis. Materials and Methods: This is a retrospective study design involving 125 biopsy-proven MGN subjects on follow-up from January 2012 to October 2019 in Hospital Serdang and Hospital Kuala Lumpur, Malaysia. Result and Conclusion: After the median follow-up of 36 (15.0-57.0) months, 26 (20.8%) consisting of 17 (13.6%) primary MGN and 9 (7.2%) secondary MGN subjects achieved complete remission while 17 (13.6%) and 10 (8.0%) of primary and secondary MGN subjects respectively achieved spontaneous remission. Subjects with nephrotic range proteinuria have 2.917 odds more at risk of primary MGN while subjects with hypertension have 2.417 odds risk of primary MGN compared to those with no hypertension at presentation. Multiple logistic regression models retained only factors directly associated with MGN with only nephrotic range proteinuria associated with primary MGN. Those with nephrotic range proteinuria were 3.04 times the odds of primary MGN when compared with those without nephrotic syndrome (95% C. I = 1.089, 8.472). The nephrotic syndrome could be used to determine the prognosis in patients with primary MGN especially those at risk of end-stage kidney disease.

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“…PMN is a rare pathological finding in pediatric patients, occupies 1.5 9% of biopsies during the corresponding period [19]. There is a rarity of data about the prognosis in children with PMN due to small samples with a fairly short follow-up period.…”

Section: Discussionmentioning

confidence: 99%

Clinical and prognostic significance of PMN in children with glomerular C1q deposition

Ren¹,

Wang²,

Xia³

et al. 2020

Preprint

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Background Currently, studies to data in MN are consistent with complement activation has an essential role in mediating renal injury, and the LP is considered to be the principal pathway in PMN. CP activation initiated by C1q which deposits are suggestive of SMN. However, C1q deposition together with IgG and C3 granular deposit is found in many cases of PMN. Currently, the clinical and prognostic significance of C1q deposition in PMN is unclear. Therefore, we conduct this single-center research to explore the clinical and prognostic significance of C1q deposition in children with PMN. Method: 73 patients with C1q deposition were enrolled in this study. According to the “Case-control matching principle”, 73 patients without C1q deposition during the same period of the renal biopsy were selected as a control group. The clinical and pathological characteristics, treatment response, and long-term renal prognosis were compared between patients with and without C1q deposition. Result A total of 146 pediatric patients with PMN included with 86 men(58.9%) and 60 women (41.1%). The median age at onset was 15.0 (14.0—16.0) years. During an average follow-up of 52.4 ± 35.6 months, 8 patients (5.5%) progressed ESKD, 12 (8.2%) patients developed ESRD or renal dysfunction. The frequency of glomerular C4 deposits in the C1q deposits group was significantly higher than no C1q deposits group (34.2% vs 5.5%, p = 0.000). There were no other distinct differences in clinical and pathological characteristics between the two groups. Glomerular IgG subclasses were available in 79 patients, there was no difference in the glomerular IgG subclass distribution between the two groups (p IgG1=0.468,p IgG2=1.000༌p IgG3=0.988༌p IgG4=0.216). The Kaplan-Meier survival analysis found that there was no difference in the renal survival of ESRD (p = 0.415) and a combined event of ESRD and/or renal dysfunction (p = 0.214) between the two groups. The logistic regression analysis (p = 0.553) and Cox regression analysis (p = 0.618) revealed that C1q deposition failed to associate with renal dysfunction. Conclusion The CP does occur in some patients of PMN. However, it may be unrelated to the progression of the disease.

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Primary Membranous Glomerulonephritis: The Role of Serum and Urine Biomarkers in Patient Management

Cited by 13 publications

References 107 publications

RETRACTED: Role of Serum and Urine Biomarkers (PLA2R and THSD7A) in Diagnosis, Monitoring and Prognostication of Primary Membranous Glomerulonephritis

RETRACTED: Role of Serum and Urine Biomarkers (PLA2R and THSD7A) in Diagnosis, Monitoring and Prognostication of Primary Membranous Glomerulonephritis

Membranous Glomerulonephritis: A Retrospective Study on Prognostic Outcome

Clinical and prognostic significance of PMN in children with glomerular C1q deposition

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