Primary melanoma of the stomach treated by BRAF inhibitor and immunotherapy

Bolzacchini, Elena; Marcon, Ilaria; Bernasconi, Giordano; Pinotti, Graziella

doi:10.1016/j.dld.2016.04.002

Cited by 9 publications

(8 citation statements)

References 1 publication

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“…Complementary therapy, such as adjuvant systemic chemotherapy, shows no benefit in overall survival and is not recommended for the treatment of such lesions 12 . Only two cases were identified where surgery was not preferred as the first‐line treatment, but the clinical course of the disease was worse than in cases that underwent surgery 55,56 . Bolzacchini et al .…”

Section: Discussionmentioning

confidence: 99%

Primary gastric melanoma in adult population: a systematic review of the literature

Schizas

Tomara

Katsaros

et al. 2020

ANZ Journal of Surgery

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Background Primary gastric melanoma (PGM) is a rare malignant tumour of the stomach with poor prognosis. The aim of this systematic review was to assess the available literature on this entity and to highlight its biological behaviour and preferred treatment approach. Methods PubMed and Cochrane bibliographical databases were independently searched (last search: 2 February 2020) by two investigators for articles reporting on PGM in the adult population. Results Twenty‐five studies met the inclusion criteria and concerned collectively 25 patients (18 males and seven females) with an age of 63.4 ± 8.97 years (mean ± standard deviation). Main symptoms included abdominal pain (64%), weight loss (48%) and hematemesis or melena (32%). The most frequent tumour location was the body of the stomach (54.2%). All tumours were surgically resected and the majority of the patients had a partial gastrectomy (52%). Median recurrence time was 5 months and 12% of patients reached 5‐year survival landmark. Conclusion PGM is a rare disease characterized by an aggressive malignant behaviour. Its differential diagnosis from a metastatic lesion is crucial. A prompt diagnosis and therapeutic approach are needed. Further studies are required to elucidate the optimal management of this clinical entity.

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Section: Discussionmentioning

confidence: 99%

Primary gastric melanoma in adult population: a systematic review of the literature

Schizas

Tomara

Katsaros

et al. 2020

ANZ Journal of Surgery

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“…Metastatic gastric melanoma are more common than primary ones; PGM are rare in clinic, and the related literature is also relatively scarce[2-5]. Imaging examination is of great value in melanoma diagnosis and reexamination.…”

Section: Discussionmentioning

confidence: 99%

“…To date, only three cases have applied CT or MRI examination (Table 1). Bolzacchini et al[2] reported a case in which CT and MRI revealed a thickened stomach wall in the lesser curvature of the stomach, and metastasis to the liver and regional lymph nodes. Wang et al[11] reported a case of primary advanced esophagogastric melanoma.…”

Section: Discussionmentioning

confidence: 99%

Primary gastric melanoma: A case report with imaging findings and 5-year follow-up

Wang

Yang

et al. 2019

WJG

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BACKGROUNDMost melanomas identified in the stomach are metastatic; primary gastric melanoma (PGM) is extremely rare, and the relevant studies are relatively scarce. PGM may be incorrectly diagnosed as other gastric malignant tumor types.CASE SUMMARYWe describe a rare case of PGM confirmed through long-term clinical observation and pathological diagnosis. A 67-year-old woman presented to our hospital with recurrent chest tightness and chest pain. Digital gastrointestinal radiography revealed a circular shadow in the gastric cardia. Computed tomography (CT) revealed a heterogeneous tumor with uneven enhancement. Enlarged lymph nodes were noted in the lesser curvature of the stomach. On magnetic resonance imaging (MRI), T1- and T2-weighted imaging revealed hyperintensity in and hypointensity in the tumor, respectively, both of which increased substantially after uneven enhancement. Near total gastrectomy was performed, and the tumor was pathologically confirmed to be a gastric melanoma. Because no other possible primary site of malignant melanoma was suspected, a clinical diagnosis of PGM was made. The patient was followed for nearly 5 years, during which she received CT reexamination, but no recurrence or metastasis was observed.CONCLUSIONCertain imaging characteristics could be revealed in PGM. Imaging examination can be of great value in preoperative diagnosis, differential diagnosis, and follow-up of patients with PGM.

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“…30% to 40% of these cases presented as detectable masses [10] or symptoms including abdominal pain, weight loss, melena, anemia, and axillary lymphadenopathy [2]. Metastasis to the liver as well as regional lymph nodes from primary gastric melanoma is common [11]. Our patient presented entirely asymptomatically.…”

Section: Discussionmentioning

confidence: 99%

“…At this time, treatment was changed to ipilimumab secondary to tumor progression. Four doses of ipilimumab were administered until the patient passed away 11 months after tumor discovery [11]. This patient's survival was significantly longer than the 5 month median survival time expected for primary gastric melanoma and is an accomplishment when the extensive disease at discovery is considered.…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Primary Extracutaneous Melanoma: Primary Gastric Melanoma and Primary Melanoma of the Lung

Holmes¹,

Chung²

2017

Med Case Rep

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Primary extracutaneous melanoma is an exceedingly rare occurrence, and primary extracutaneous melanomas arising in tissues thought to be devoid of melanocytes are even rarer. The paper that follows describes two such cases, one case of primary gastric melanoma and one case of primary melanoma of the lung. Both cases were treated solely with surgical excision of the lesion, and the patients have experience no recurrent disease. Novel approaches to treat extracutaneous melanomas are also discussed.

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Primary melanoma of the stomach treated by BRAF inhibitor and immunotherapy

Cited by 9 publications

References 1 publication

Primary gastric melanoma in adult population: a systematic review of the literature

Primary gastric melanoma in adult population: a systematic review of the literature

Primary gastric melanoma: A case report with imaging findings and 5-year follow-up

Two Cases of Primary Extracutaneous Melanoma: Primary Gastric Melanoma and Primary Melanoma of the Lung

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