Primary Melanoma of the Lung

Scolyer, Richard A.; Bishop, James F.; Thompson, John F.

doi:10.1002/9781118464557.ch23

Cited by 2 publications

(4 citation statements)

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“…In addition, CT did not reveal a solitary lesion in the occipital lobe upon initial admission. Moreover, according to the clinical and pathological criteria proposed by Allen and Drash and others [ 1 , 8 , 17 ]– 1) no history suggestive of a previous melanoma; 2) no demonstrable melanoma in any other organ at the time of surgery; 3) a solitary tumor in the surgical specimen from the lung; 4) tumor morphology compatible with that of a primary tumor; 5) no evidence at autopsy of a primary melanoma elsewhere; 6) obvious melanoma cells confirmed by immunohistochemical staining for S-100 and HMB-45, and possibly by electron microscopy; 7) evidence of junctional change; 8) “nesting” of cells beneath the bronchial epithelium; 9) invasion of the intact bronchial epithelium by melanoma cells – we concluded that the aforementioned data were indicative of primary lung melanoma with intrapulmonary metastasis. Moreover, we considered that the ninth view described in the above diagnostic criteria was an important characteristic of primary pulmonary melanoma besides the evidence of histopathological and immunohistochemical staining according to the features of our both cases.…”

Section: Discussionmentioning

confidence: 99%

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Primary pulmonary malignant melanoma: a clinicopathologic study of two cases

et al. 2012

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Malignant melanoma involving the respiratory tract is nearly always metastatic in origin, and primary tumors are very rare. To our knowledge, about 30 cases have been reported in the English literature, one of which involved multiple brain metastases. Here, we report two cases of primary pulmonary malignant melanoma. The first case, which occurred in a 52-year-old Chinese female patient who died 4 months after the initial diagnosis, involved rapid intrapulmonary and intracranial metastases. The second patient, a 65-year-old female, underwent surgical excision, and clinical examination, histopathological characteristics, and immunohistochemical features supported the diagnosis of pulmonary malignant melanoma. No evidence for recurrence and/or metastasis has been found more than one year after the initial surgery. To establish the diagnosis of primary pulmonary malignant melanoma, any extrapulmonary origin must be excluded by detailed examination. Moreover, the tumor should be removed surgically whether it occurs as a single lesion or multiple lesions.Virtual slideThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1480477335765055.

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Section: Discussionmentioning

confidence: 99%

“…Malignant melanoma occurs most frequently on the skin, but can also arise in other organs and tissues of the body. However, primary pulmonary malignant melanoma is exceedingly rare [ 1 ]. To date, about 30 cases have been reported in the English literature [ 2 ] , one of which involved multiple brain metastases [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Primary pulmonary malignant melanoma: a clinicopathologic study of two cases

et al. 2012

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“…2,6,7) Fewer than 60 such cases have been documented in the English literature. Late recurrence of MM is also infrequent, although it appears to be a growing problem.…”

Section: Discussionmentioning

confidence: 99%

“…1) Almost every occurrence of MM of the lung is metastatic in origin. Primary MM of the lung is quite rare, 2) and for its diagnosis, an extrapulmonary origin of the tumor must be excluded by detailed examination of the sites where MM occurs frequently, such as the skin or mucosa.…”

Section: Introductionmentioning

confidence: 99%

Malignant Melanoma of the Lung: Report of Two Cases

Neri

Komatsu

Kitamura

et al. 2011

ATCS

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Malignant melanoma (MM) is the most fatal cutaneous neoplasm. Primary MM of the lung is quite rare, and late recurrence of MM is also uncommon. We report 2 cases of pulmonary MM, the first involving primary MM of the lung and the second involving late recurrence 8 years after the initial surgery. Bronchoscopic punch biopsy identified MM in both cases. In the first case, work-up of the patient did not reveal any anomalies other than those in the primary site. In the second case, the patient had a history of thumb amputation for MM 8 years ago. For pulmonary MM, extrapulmonary origin of the tumor must be excluded by detailed examination because melanomas involving the lung are almost always metastatic. Whether the diagnosis is primary or metastatic disease, the potential for recurrence should be considered even in patients with a long disease-free survival.

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Primary Melanoma of the Lung

Cited by 2 publications

References 89 publications

Primary pulmonary malignant melanoma: a clinicopathologic study of two cases

Primary pulmonary malignant melanoma: a clinicopathologic study of two cases

Malignant Melanoma of the Lung: Report of Two Cases

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