Primary Melanoma of the Lung

Scolyer, Richard A.; Thompson, John F.

doi:10.1002/0470030542.ch24

Cited by 10 publications

(4 citation statements)

References 67 publications

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“…Lung is one of the most common sites of metastasis of MM of extrapulmonary origin with an incidence of 70–82%. Usually primary pulmonary malignant melanoma (PMM) appears as solitary or multiple discrete nodules, and diffuse interstitial infiltrative pattern is rare and can be misdiagnosed due to more commonly accompanying conditions including pulmonary edema or drug-induced pneumonia [12] . Both endobronchial and lymph node involvement are common in this type of melanoma in contrast to melanoma that has metastasized to the lung [2] .…”

Section: Discussionmentioning

confidence: 99%

Dark sputum: An atypical presentation of primary pulmonary malignant melanoma

Filippini

Zorzi

Bnà

et al. 2015

Respiratory Medicine Case Reports

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Primary melanoma of the lung is an extremely rare clinical entity. We found only 32 cases reported in literature, and in two of these multiple brain metastases were present. We describe a case of primary lung melanoma with brain and skin metastases that presented with an initial clinical diagnosis of pneumonia.A 55-year-old white man presented with cough productive of dark sputum and fever. A chest x-ray showed a right lung infiltration. After failure to respond to usual treatment for pneumonia, bronchoscopy examination and CT scan revealed a right pulmonary mass. The CT-guided biopsy confirmed a diagnosis of malignant melanoma. The primary lung origin of the tumor was demonstrated by the characteristic junctional pattern of melanoma cells. Further evaluation revealed metastases in the brain and in skin.Primary lung melanoma is an uncommon neoplasm that may be confused with more conventional types of lung cancer. Careful interpretation of histopathological information in correlation with all other clinical, laboratory and imaging studies may be needed to establish a diagnosis. Evaluation for metastases should include looking at the eyes, brain, skin. Due to the small number of cases reported in literature, there is no experience on the management and the prognosis of the disease.

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Section: Discussionmentioning

confidence: 99%

Dark sputum: An atypical presentation of primary pulmonary malignant melanoma

Filippini

Zorzi

Bnà

et al. 2015

Respiratory Medicine Case Reports

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“…In addition, CT did not reveal a solitary lesion in the occipital lobe upon initial admission. Moreover, according to the clinical and pathological criteria proposed by Allen and Drash and others [1,8,17]– 1) no history suggestive of a previous melanoma; 2) no demonstrable melanoma in any other organ at the time of surgery; 3) a solitary tumor in the surgical specimen from the lung; 4) tumor morphology compatible with that of a primary tumor; 5) no evidence at autopsy of a primary melanoma elsewhere; 6) obvious melanoma cells confirmed by immunohistochemical staining for S-100 and HMB-45, and possibly by electron microscopy; 7) evidence of junctional change; 8) “nesting” of cells beneath the bronchial epithelium; 9) invasion of the intact bronchial epithelium by melanoma cells – we concluded that the aforementioned data were indicative of primary lung melanoma with intrapulmonary metastasis. Moreover, we considered that the ninth view described in the above diagnostic criteria was an important characteristic of primary pulmonary melanoma besides the evidence of histopathological and immunohistochemical staining according to the features of our both cases.…”

Section: Discussionmentioning

confidence: 99%

“…However, primary pulmonary malignant melanoma is exceedingly rare [1]. To date, about 30 cases have been reported in the English literature [2] , one of which involved multiple brain metastases [3].…”

Section: Introductionmentioning

confidence: 99%

Primary pulmonary malignant melanoma: a clinicopathologic study of two cases

et al. 2012

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Malignant melanoma involving the respiratory tract is nearly always metastatic in origin, and primary tumors are very rare. To our knowledge, about 30 cases have been reported in the English literature, one of which involved multiple brain metastases. Here, we report two cases of primary pulmonary malignant melanoma. The first case, which occurred in a 52-year-old Chinese female patient who died 4 months after the initial diagnosis, involved rapid intrapulmonary and intracranial metastases. The second patient, a 65-year-old female, underwent surgical excision, and clinical examination, histopathological characteristics, and immunohistochemical features supported the diagnosis of pulmonary malignant melanoma. No evidence for recurrence and/or metastasis has been found more than one year after the initial surgery. To establish the diagnosis of primary pulmonary malignant melanoma, any extrapulmonary origin must be excluded by detailed examination. Moreover, the tumor should be removed surgically whether it occurs as a single lesion or multiple lesions.Virtual slideThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1480477335765055.

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“…It occurs most frequently on the skin, but also occurs in other organs and tissues of the body. However, melanoma of the lung without evidence of extrapulmonary disease, i.e., primary pulmonary melanoma, is very rare 1 .…”

Section: Introductionmentioning

confidence: 99%

Primary Pulmonary Malignant Melanoma: An Unexpected Tumor

Hwang

Jung

et al. 2015

Tuberc Respir Dis

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Malignant melanoma occurs most frequently on the skin. However, it can also arise in other organs and tissues of the body. Primary pulmonary malignant melanoma is a very rare non-epithelial neoplasm accounting for 0.01% of all primary pulmonary tumors. The treatment of choice is surgical resection of the tumor with an oncologically adequate margin as in lobectomy or pneumonectomy. The prognosis of this condition is rather poor. Based on previous data, its 5-year survival is at least 10%. Here, we report a case of an 82-year-old woman whose primary pulmonary melanoma was detected incidentally.

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Primary Melanoma of the Lung

Cited by 10 publications

References 67 publications

Dark sputum: An atypical presentation of primary pulmonary malignant melanoma

Dark sputum: An atypical presentation of primary pulmonary malignant melanoma

Primary pulmonary malignant melanoma: a clinicopathologic study of two cases

Primary Pulmonary Malignant Melanoma: An Unexpected Tumor

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