Primary malignant peripheral nerve sheath tumor of the breast

Agarwal, Rishu; Sinha, Deepika; Tomar, Reena; Mandal, Shramana; Bains, Lovenish; Jain, Shyama

doi:10.1111/tbj.13315

Cited by 4 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MPNSTs are most commonly located in the trunk, extremities and head and neck ( 1 ). However, MPNSTs involving the breast are rare ( 2 3 4 5 6 7 ), and in particular, breast metastasis is extremely rare ( 8 9 ).…”

Section: Discussionmentioning

confidence: 99%

Imaging Findings of Breast Metastasis from Malignant Peripheral Nerve Sheath Tumor of Mediastinum: A Case Report

Park

Joo

2023

J Korean Soc Radiol

View full text Add to dashboard Cite

Malignant peripheral nerve sheath tumor (MPNST), a rare soft-tissue sarcoma, is most commonly located in the trunk, extremities, and head and neck, but rare in the breast. We report a metastatic breast MPNST in a 27-year-old woman with neurofibromatosis type 1 (NF-1). Chest computed tomography revealed a well-defined, oval, mildly enhancing nodule in the right breast. US revealed a circumscribed, oval, heterogeneous echoic mass with vascularity and intermediate elasticity in the right upper outer breast. The breast mass was excised and diagnosed as MPNST on histopathology evaluation. Although rare, it should be included in the differential diagnosis of breast mass in NF-1 patient.

show abstract

Section: Discussionmentioning

confidence: 99%

Imaging Findings of Breast Metastasis from Malignant Peripheral Nerve Sheath Tumor of Mediastinum: A Case Report

Park

Joo

2023

J Korean Soc Radiol

View full text Add to dashboard Cite

show abstract

“…Larger tumor size (greater than 5 cm), presence of NF-1, tumor grade, invasion, and heterologous rhabdomyoma differentiation are the adverse prognostic factors. However, in the literature, no report is available on the median survival or prognosis of MPNSTs of the breast [ 3 , 10 ]. Our patient has not experienced any local reoccurrence or distant metastasis since radical surgical excision.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Multiple cases of sporadic and NF-1-associated MPNST have been reported in the literature. According to our search and availability of online databases, 15 cases have been compiled and listed in Table 1[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24].Chalkoo M, Ahangar S, Laharwal A, Patloo A, Mohd A, Dar S. Primary Malignant Peripheral Nerve Sheath Tumor of the Breast-A Case Report. Surg Sci [22].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Primary Malignant Peripheral Nerve Sheath Tumor of the Breast: A Rare Case Report and Review of Literature

Tahir¹,

Zedan²,

Bellamkonda³

et al. 2022

Cureus

View full text Add to dashboard Cite

Primary breast sarcomas are uncommon and primary mammary malignant peripheral nerve sheet tumors (MPNST) are exceptionally rare. MPNSTs are malignant variants of peripheral nerve sheath tumors. These neoplasms are often associated with neurofibromatosis type I (NF-I) but can also occur sporadically. They tend to occur in the deeper soft tissues, trunk, and extremities.A 60-year-old Asian female was referred to our surgical clinic for evaluation of a left breast mass and an abnormal mammogram. The patient noticed the mass in the left breast three months earlier and was referred for mammography by her primary physician. Mammography reported partially defined masses in the superior aspect of the left breast, and ultrasound showed a solid mass measuring 5.2 X 3 cm. The mass was 11 cm on clinical exam. Subsequent core biopsy of the left breast lesion showed high-grade malignant neoplasm. Workup showed no evidence of metastatic disease, and the patient underwent modified radical mastectomy. The neoplastic cells were positive for CD99, S-100, SOX-10, neuron specific enolase, p53, vimentin, focally positive for neurofilament, D2-40, p63, and negative for epithelial, melanoma and other sarcoma markers. The tumor was triple negative estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), with Ki-67 at 61%. A diagnosis of primary high grade malignant peripheral nerve sheath tumor of the breast was rendered. The patient does not have a history of NF-1.An accurate diagnosis of this rare entity is necessary because it plays a crucial role in the therapeutic options and prognosis. In our case the patient underwent modified radical mastectomy. The purpose of presenting this unique case is to provide awareness of the existence of this entity among pathologists and clinicians for better patient care.

show abstract

“…The high precision and speed of modern radiotherapy have higher requirements on the real-time of modern radiotherapy (30)(31)(32). In the era of image-guided radiotherapy, one of the major concerns is whether radiation can be "seen" in the target area, and can be adjusted according to the change of the target area.…”

Section: Discussionmentioning

confidence: 99%

Study on the value of multi-dimensional conformal radiotherapy and functional imaging in tumor bioimaging

Huang¹,

He²,

Xiong³

et al. 2022

Transl Cancer Res TCR

View full text Add to dashboard Cite

Background: To explore the diagnostic and therapeutic effects of multi-dimensional conformal radiotherapy (MD-CRT) combined with functional imaging in tumor bioimaging.Methods: A total of 150 cases of patients with brain metastases in First Affiliated Hospital of Xi'an Jiaotong University between December 2020 and December 2021 were retrospectively selected as the research cohort. Participants underwent whole brain imaging guided by MD-CRT combined with volume assessment to assess the patient's recent treatment effect, statistically acceptable dose irradiation treatment, and the incidence of adverse reactions. All patients were followed up to evaluate the long-term efficacy.Results: Among the 150 patients, 24 cases were in complete remission, 72 cases were in partial remission, 36 cases were in a stable condition, 18 cases were in deterioration, and the treatment of 96 cases (64.00%) was deemed effective. All participants were followed up, the mean survival was (62.37±1.24) months, 96 cases (64.00%) survived, and 54 cases (36.00%) had died. The average dose was (62.09±3.94) Gy. In terms of adverse reactions: brain edema occurred in 57 patients, accounting for 38.00%. Conclusions:The MD-CRT and functional imaging techniques for patients with metastatic tumor have high therapeutic accuracy, are associated with improved local control rate, prolonged survival, and cause little damage to normal tissues, with significant therapeutic effect, and can be widely used in clinical practice.

show abstract

Primary malignant peripheral nerve sheath tumor of the breast

Cited by 4 publications

References 0 publications

Imaging Findings of Breast Metastasis from Malignant Peripheral Nerve Sheath Tumor of Mediastinum: A Case Report

Imaging Findings of Breast Metastasis from Malignant Peripheral Nerve Sheath Tumor of Mediastinum: A Case Report

Primary Malignant Peripheral Nerve Sheath Tumor of the Breast: A Rare Case Report and Review of Literature

Study on the value of multi-dimensional conformal radiotherapy and functional imaging in tumor bioimaging

Contact Info

Product

Resources

About