Primary malignant pericardial mesothelioma - a rare cause of pericardial effusion and consecutive constrictive pericarditis: a case report

Butz, Thomas; Faber, Lothar; Langer, C.; Körfer, Jan; Lindner, Oliver; Tannapfel, Andrea; Müller, Klaus‐Michael; Meißner, Axel; Plehn, Gunnar; Trappe, Hans‐Joachim; Horstkotte, Dieter; Piper, Cornelia

doi:10.1186/1752-1947-0003-0000009256

Cited by 28 publications

(24 citation statements)

References 9 publications

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“…Median survival is only six months after symptom onset, although pericardiectomy (frequently partial) is palliative in the case of constrictive pericarditis. 3 Resection was incomplete in the case presented, and so it was not possible to resolve the patient's hemodynamic instability. The presence of ischemic colitis was interpreted as probably due to poor perfusion, although an embolic event due to the malignancy cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

“…6 Few cases have been reported in the literature and antemortem diagnosis is infrequent. 3 It predominantly affects men (3:1), between the fifth and seventh decades of life, although cases have been reported at younger and older ages. 7 Clinical presentation can include the whole spectrum of manifestations of pericardial disease, from the mildest to the final stage of constrictive pericarditis.…”

Section: Discussionmentioning

confidence: 99%

“…2 Scintigraphy also has a role in diagnosis and stratification, as with other forms of cancer. 3 A definitive diagnosis always requires histological analysis. 2 Clinical presentation may be atypical or may mimic benign etiologies.…”

Section: Discussionmentioning

confidence: 99%

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A rare cause of pericardial disease

Ramos

Vieira

Fernandes

et al. 2013

Revista Portuguesa de Cardiologia (English Edition)

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Among cardiovascular diseases, pericardial disease has specific characteristics. Its etiology, diagnosis and medical management are not as well understood as in coronary and valvular heart disease. In most cases, its cause is benign, although the proportion decreases with more severe clinical presentation.The authors present the case of a 35-year-old man with no relevant past medical history, who went to the emergency department with what appeared to be an idiopathic case of acute pericarditis. However, over the following five months, there was an unfavorable evolution to constrictive pericarditis, requiring pericardiectomy. The final diagnosis was only made following surgery ---a rare case of a primary pericardial tumor, a mesothelioma. © 2012 Sociedade Portuguesa de Cardiologia. Published by Elsevier España, S.L. All rights reserved. PALAVRAS-CHAVE Pericardite constritiva; MesoteliomaCausa rara de doença pericárdica Resumo As doenças do pericárdio apresentam-se como uma patologia particular do foro cardiovascular. Os seus componentes etiológicos e a gestão diagnóstica e terapêutica não estão tão bem compreendidos e estudados, comparativamente com outras áreas, como a doença coronária ou valvulopatias. Maioritariamente, a etiologia é benigna, mas a sua proporção diminui à medida que a apresentação e evolução clínicas são mais exuberantes.Os autores descrevem um caso de um homem de 35 anos de idade, sem antecedentes clínico-patológicos de relevo conhecidos, que se apresenta num Serviço de Urgência com o que aparenta ser um episódio de pericardite aguda de etiologia idiopática. Contudo, ao longo de cinco meses, evolui desfavoravelmente, com necessidade de orientação para pericardiectomia por pericardite constritiva. Apenas no bloco operatório foi feito o diagnóstico etiológico final. Tratava-se de um caso muito raro de neoplasia primária do pericárdio, um mesotelioma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A rare cause of pericardial disease

Ramos

Vieira

Fernandes

et al. 2013

Revista Portuguesa de Cardiologia (English Edition)

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“…Compared with other cases, the time interval between the previous pericardial effusion and the current presentation were too long for a diagnosis of recurrent pericardial effusion in the present case, making it difficult to connect with PMPM. However, PMPM should be considered as a cause of unexplained recurrent pericardial effusion, considering previous cases (6,7,21,22).…”

Section: Discussionmentioning

confidence: 99%

Positive response of a primary malignant pericardial mesothelioma to pemetrexed plus cisplatin followed by pemetrexed maintenance chemotherapy: A case report

et al. 2016

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Abstract. Primary malignant pericardial mesothelioma (PMPM) is a rare tumor with poor prognosis. Surgery is the treatment of choice, but numerous cases are inoperable. For the treatment of inoperable or metastatic cases, systemic chemotherapy is required. However, a standard chemotherapeutic regimen for the treatment of pericardial mesothelioma has not yet been established. Chemotherapy involving pemetrexed and cisplatin has been actively used in the treatment of pleural or peritoneal mesothelioma, and may be considered for the treatment of PMPM. The present study reports the case of a patient with PMPM with lung metastasis who demonstrated a positive response to treatment with pemetrexed and cisplatin followed by pemetrexed maintenance chemotherapy, leading to prolonged progression-free survival for 21 months.

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“…PMPM accounts for approximately 2-3% of all cardiac and pericardial primary tumors and approximately 1% of all mesotheliomas (3,4). In an epidemiological survey, the incidence of PMPM was estimated to be 0.0022% (5). Making an antemortem diagnosis of PMPM is challenging and misdiagnosis is common (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Primary Malignant Sarcomatoid Mesothelioma in the Pericardium

et al. 2013

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Primary malignant pericardial mesothelioma is an exceptionally rare tumor, and making an antemortem diagnosis of this disease is notoriously difficult. We herein report the case of a 61-year-old woman with pericardial mesothelioma who presented with shortness of breath and peripheral edema of the lower limbs. Chest computed tomography (CT) showed an anterior mass and thickened pericardium with multiple pericardial nodules. A biopsy of the mediastinal mass was performed using right thoracotomy, and the histological findings indicated a sarcomatoid tumor. The patient was treated with chemotherapy; however, she but died three months after diagnosis. An autopsy confirmed a final diagnosis of sarcomatoid type primary malignant pericardial mesothelioma following extensive immunohistopathological examinations.

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Primary malignant pericardial mesothelioma - a rare cause of pericardial effusion and consecutive constrictive pericarditis: a case report

Cited by 28 publications

References 9 publications

A rare cause of pericardial disease

A rare cause of pericardial disease

Positive response of a primary malignant pericardial mesothelioma to pemetrexed plus cisplatin followed by pemetrexed maintenance chemotherapy: A case report

Primary Malignant Sarcomatoid Mesothelioma in the Pericardium

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