Primary malignant melanoma of the oral mucosa

Greene, George W.; Haynes, James W.; Dozier, M; Blumberg, Jeffrey M.; Bernier, Joseph L.

doi:10.1016/0030-4220(53)90242-4

Cited by 89 publications

(36 citation statements)

References 2 publications

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“…Criteria for diagnosis of primary oral melanoma were originally put forth by Greene et al [12] in 1953. These criteria include: (1) Intraepidermal (junctional) activity, (2) Evidence of malignant melanoma in the oral mucosa, and (3) Failure to demonstrate any other primary site.…”

Section: Introductionmentioning

confidence: 99%

Melanoma of the Oral Cavity: an Analysis of 46 New Cases with Emphasis on Clinical and Histopathologic Characteristics

Smith

Bhattacharyya

Cohen

et al. 2016

Head and Neck Pathol

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Melanoma of the oral cavity is a rare malignancy that carries a poor prognosis. We identified 46 new cases of both primary and metastatic melanoma to the oral cavity. Following IRB approval, these cases were obtained from the Oral Pathology Biopsy Service archives of the UF College of Dentistry (1994Dentistry ( -2014, the UK College of Dentistry (1997Dentistry ( -2015, and the UM Medical Center . All slides were reviewed. The location, age, race, gender, clinical impression, duration of lesion, histopathologic diagnosis, and histopathologic features were recorded. Cases from the facial skin and those with an ambiguous diagnosis were excluded. Forty-six cases fulfilled the inclusion criteria with 32 primary cases, 11 known metastases, and 3 cases where metastasis could not be excluded. The primary cases included a total of 20 females and 12 males with an average age of 66.7 (range 27-95), and the majority (80 %) of the patients were Caucasian when race was known. Twenty-two of the 32 primary cases (68.8 %) were located in the maxillary mucosa, 5 in the mandibular mucosa or bone, and 5 in other locations. The clinicians' impressions varied from benign fibrous growths to high grade malignancies. The histopathology varied widely among the cases, however two cell types predominated (often in combination): epithelioid cells (50.0 %) and spindle cells (50.0 %). Only 53.1 % demonstrated melanin pigmentation. Oral melanoma remains one of the most diverse clinical and histopathologic diagnoses. Better understanding of this neoplasm may promote earlier diagnosis and may lead to improved outcomes.

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Section: Introductionmentioning

confidence: 99%

Melanoma of the Oral Cavity: an Analysis of 46 New Cases with Emphasis on Clinical and Histopathologic Characteristics

Smith

Bhattacharyya

Cohen

et al. 2016

Head and Neck Pathol

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“…[5] The criteria for the diagnosis of primary oral melanoma described by Greene et al are confirmation of oral mucosal melanoma, presence of junctional activity, and inability to identify any other primary site. [6] According to Green's criteria, we diagnosed our case to be a primary oral melanoma.…”

Section: Discussionmentioning

confidence: 99%

Malignant melanoma of the mandibular gingiva

Aroquiadasse¹,

Malik²,

Ramesh³

et al. 2017

IJMDCR

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Malignant melanoma is a perilous tumor originating from melanocytes. Malignant melanoma of the oral cavity has a sporadic occurrence and accounts for about <1% of all oral malignancies. The tumor most commonly occurs in the palate and the maxillary gingiva in the oral cavity, and seldom involves the mandibular gingiva. In this article, we report a 41-year-old man with primary oral malignant melanoma, which presented as a pedunculated pigmented growth involving the mandibular ridge associated with the lower front teeth. Focus is laid on early identification and reporting of such cases. Appropriate knowledge coupled with a high index of clinical suspicion about melanotic lesions may help in early diagnosis of this rare pathology.

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“…The lesion is usually asymmetric with irregular borders, and the surface may be smooth or ulcerated. A variety of colors may show in oral malignant melanoma with black, activity in the oral mucosa and (3) inability to show any other primary site [11]. However, melanoma metastasis may also involve the epithelial junction, however the presence of junctional activity is not reliable to indicate the lesion as a primary one.…”

Section: Discussionmentioning

confidence: 99%

Oral Mucosa Malignant Melanoma: Clinical Features, Diagnosis, Treatment, and a Case Report

Huang¹

2015

J Dent Probl Solut

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Primary oral mucosa malignant melanoma is a rare and biologically aggressive neoplasm. It is estimated about 1~2% of all oral malignancies with the incidence increasing with age. The prognosis of oral mucosa malignant melanoma is poor with the five-year survival rate is approximately 15%. The diagnosis of oral melanoma is usually delayed because it is always asymptomatic at the beginning and it resembles the epulis, amalgam tattoo or other oral lesions. In addition, nearly a third of all oral melanoma are amelanotic and may lack a radial growth phase, which makes early and accurate diagnosis even difficult. Thus, regional and distant metastases happen more frequently. Surgery is the first choice of treatment, and clinically negative necklymph nodes with neck dissection or radiotherapy are also recommended because of the high risk of subclinical regional metastasis.In this article, we reviewed the clinical features, diagnosis, treatment, and presented a 70 y/o male who suffered from an easily bleeding lesion over right posterior palatal mucosa and gingiva who presented at hospital for help. We performed biopsy which revealed a malignant melanoma. He received supraomohyoid neck lymph node dissection, partial maxillectomy, and was reconstructed with anterior lateral thigh free fascia cutaneous flap. After surgical treatment, the patient kept regular follow-ups. The treatment outcome was good and the patient recovered with full swallowing and phonation function.components. In some cases, they may have no melanin production (amelanotic melanoma). This may also be one of the challenges to make an accurate diagnosis because melanoma can mimic a variety of undifferentiated tumors. Histological differential diagnoses included malignant lymphoma, amelanotic melanoma, spindle cell malignancies of mesenchymal tissues, and undifferentiated carcinoma. Immunohistochemical studies such as S-100 protein, HMB-45, Melan-A and Mart-1 reactivity of the tumor cells are beneficial in distinguishing such melanomas from other malignancies [4].The prognosis of oral mucosa malignant melanoma is extremely poor in relationship to its cutaneous counterpart. The 5-year survival rate is around 13%~22%. It may be resulted from delayed diagnosis and treatment, the aggressive nature of the disease, difficulty in achieving wide resection and a tendency for early hematogenous metastasis. Therapy of oral mucosa malignant melanoma is commonly based on surgical excision of the primary tumor, but it may be challenge depending on the anatomic location within the oral cavity and extent of tumor. Although melanoma is traditionally considered to be radioresistant, some authors have described improved survival and local control with postoperative radiotherapy [1,4]. In some studies, chemotherapy and immunotherapy are served as adjunctive therapies. However, there are still no guidelines or consensus in treatment of oral mucosa malignant melanoma. In this article, we reported a case of primary oral mucosa malignant melanoma over right maxillary gingi...

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Primary malignant melanoma of the oral mucosa

Cited by 89 publications

References 2 publications

Melanoma of the Oral Cavity: an Analysis of 46 New Cases with Emphasis on Clinical and Histopathologic Characteristics

Melanoma of the Oral Cavity: an Analysis of 46 New Cases with Emphasis on Clinical and Histopathologic Characteristics

Malignant melanoma of the mandibular gingiva

Oral Mucosa Malignant Melanoma: Clinical Features, Diagnosis, Treatment, and a Case Report

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