Primary malignant melanoma of the female urethra: A radiologic–pathologic correlation

Amiraian, Dana; Cernigliaro, Joseph G.; Zhai, Qihui; Petrou, Steven

doi:10.1016/j.ctrc.2015.01.003

Cited by 6 publications

(9 citation statements)

References 9 publications

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“…MRI can be used for diagnosis of urethral MM and evaluation of the tumor extent [26] [27]. Melanin may not follow the same MRI intensity pattern as other urethral tumors, since its appearance may depend on the intralesional melanin content [27].…”

Section: Discussionmentioning

confidence: 99%

Primary Urethral Malignant Melanoma in an Elder Woman Diagnosed by Urine Cytology

Niwa¹,

Ishihara²,

Mori³

et al. 2020

OJPathology

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Primary urethral malignant melanoma is an extremely rare malignancy with early metastasis and often delayed diagnosis, resulted in poor prognosis. Literature on this entity, especially with regard to urinary cytology is limited. We report here an extremely rare case of primary urethral malignant melanoma (MM) developed in a 95-year-old Japanese woman. A urinalysis showed macrophages containing brown granular pigments, and the urinary cytology was positive for atypical cells containing brown pigments suggestive of MM. Pathological examination of the biopsy specimen from the tumor revealed MM of the urethra. Immunohistochemically, the tumor cells showed strong cytoplasmic reactivities against antibodies, HMB-45 and Malan-A. Melanoma cells were immunohistochemically positive for c-Kit in their cytoplasm and cell membrane, although mutations in BRAF V600E and N/K-RAS were not detected. The urinary cytology and immunohistochemistry were useful for the rapid and accurate diagnosis for the urethral MM.

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Section: Discussionmentioning

confidence: 99%

Primary Urethral Malignant Melanoma in an Elder Woman Diagnosed by Urine Cytology

Niwa¹,

Ishihara²,

Mori³

et al. 2020

OJPathology

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“…Primary malignant melanoma of the urethra is extremely rare, accounting less than 1% of all melanomas and 4% of all urethral cancers. 1 It has a 3:1 female predominance, 1 , 2 and its more frequent in Caucasian population. 2 Most cases are diagnosed after the fifth decade, 3 with an average age of 65 years.…”

Section: Discussionmentioning

confidence: 99%

“… 2 Most cases are diagnosed after the fifth decade, 3 with an average age of 65 years. 1 Presenting symptoms include vaginal bleeding, palpable urethral mass, hematuria, dysuria and obstructive voiding symptoms. 1 , 2 …”

Section: Discussionmentioning

confidence: 99%

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Primary malignant urethral melanoma resembling a urethral caruncle

Safadi

Schwalb

Ben‐Shachar

et al. 2017

Urology Case Reports

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“…The patient is doing fine at 3 months follow-up with no evidence of recurrence/distant metastasis. Primary malignant melanomas of urethra are rare tumours comprising less than 1% of all urethral tumours 1. Both melanoma and urethral caruncle occur in postmenopausal women and can have similar clinical presentation of dysuria, intermittent vaginal bleeding, mass arising from anterior wall of urethra, haematuria and obstructive lower urinary tract symptoms 1 2.…”

Section: Descriptionmentioning

confidence: 99%