Primary Malignant Melanoma of the Uterine Cervix

Mousavi, Azam Sadat; Fakor, F; Nazari, Zeinab; Ghaemmaghami, Fatemeh; Hashemi, Fatemeh; Jamali, Mansour

doi:10.1097/01.lgt.0000229564.11741.4e

Cited by 36 publications

(15 citation statements)

References 22 publications

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“…Primary malignant melanoma of the cervix constitutes a rare disease,[4567] representing <2% of cases of malignant melanoma that affects the female genital tract. [4] Due to that the cervix is an unusual site for this type of neoplasm, the FIGO staging system for cervical cancer is used,[8] rather than the Clark and Breslow scales because the FIGO staging system correlates better with the prognosis.…”

Section: Discussionmentioning

confidence: 99%

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Sarcomatoid carcinoma of the cervix with foci of malignant melanoma

Shrivastava¹,

Barmon²,

Deka³

et al. 2014

J Mid-life Health

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Introduction:Sarcomatoid squamous cell carcinoma (SSCC) is a rare malignancy of the cervix. Until date around eighteen cases of SSCC have been reported in the literature. It is an aggressive tumor with poor prognosis. The tumor usually presents at an advanced stage. Similarly, primary melanomas of the uterine cervix are rare tumors with not more than 60 cases reported in the world literature. It also has a poor prognosis. There is no reported case of sarcomatoid carcinoma with malignant melanoma. Here, we are presenting a rare case of cervical carcinoma with histopathology suggestive of SSCC with foci of malignant melanoma proven by immunohistochemistry study.Case Report:The present case report is about a 42-year-old, Mrs. SR, P5 L3 D1 A1 , presented with the complaints of intermittent bleeding per vaginum since last 3 years and severe pain in the right lower limb since 1 month. On examination, there was a proliferative growth in the cervix. Her magnetic resonance imaging (MRI) showed cervical mass lesion with right parametrial extension invading the right ureter and bladder wall causing hydroureteronephrosis with contiguous bilateral pelvic nodes. There were multiple lesions in the left femur. Diagnosis of carcinoma of cervix International Federation of Gynecology and Obstetrics stage IIIB with distant metastasis was made. Histopathology report was suggestive of sarcomatoid carcinoma with foci of melanocytic melanoma. She was planned to be treated with palliative radiation.Discussion:About 90% of cervical carcinomas are squamous cell carcinoma. Adenocarcinoma constitute about 3-4% of all cervical carcinomas. Other rare pathologies are lymphoma, melanoma, sarcoma and metastatic tumors. Our case is a rare combination of sarcomatoid carcinoma with foci of malignant melanoma of cervix.

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Section: Discussionmentioning

confidence: 99%

“…[1112] Adjuvant pelvic RT is considered in the case of positive surgical resection margins, when the parametrium is involved, or when lymph nodes are found to be involved. [4813] Adjuvant radiation may improve local control if the surgical margins are close.…”

Section: Discussionmentioning

confidence: 99%

Sarcomatoid carcinoma of the cervix with foci of malignant melanoma

Shrivastava¹,

Barmon²,

Deka³

et al. 2014

J Mid-life Health

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“…Although there is no enough information about the real role of negative margins in primary melanoma of the cervix, the primary surgery should have the purpose of obtaining negative margins [7]; some authors recommend 2-cm margins as minimum [10,13]. The role of radiotherapy (RT) has not been well established, but it has been demonstrated that RT reduces the tumor size [4,9,11]. The use of adjuvant pelvic RT is considered in the case of not obtaining a satisfactory surgical resection margins, when the parametrium is involved, or when lymph nodes are found to be involved [7].…”

Section: Discussionmentioning

confidence: 99%

“…Age range varies from 20 to 78 years [7], being more common between 60 and 70 years [9]. Due to that the cervix is an unusual site for this type of neoplasm, the International Federation of Gynecology and Obstetrics (FIGO) staging system for cervical cancer is used [11], rather than the Clark and Breslow scales, because the FIGO staging system correlates better with the prognosis. Diagnosis of primary melanoma of the cervix entertains a high probability of being confused with another entity, due to the rarity of the disease [10].…”

Section: Discussionmentioning

confidence: 99%

Unusual primary location of the malignant melanoma, the cervico-vaginal region: 3 cases and literature review

Hinde¹,

Bennani²,

Hannane³

et al. 2012

OJOG

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“…At present, there is no consensus on the therapeutic approach to follow [1, 2, 7]; in the reports found, initial treatment is referred of radical hysterectomy accompanied or not by radical pelvic lymphadectomy or superior vaginectomy [1, 2, 6–11]. …”

Section: Introductionmentioning

confidence: 99%

Primary Malignant Melanoma of the Uterine Cervix Treated with Ultraradical Surgery: A Case Report

Calderón-Salazar

León

Montiel

et al. 2011

ISRN Obstetrics and Gynecology

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Primary melanomas of the uterine cervix are rare tumors with no more than 60 cases reported in the world literature. Poor prognosis is considered for the neoplasia itself as well as for diagnostic tardiness. There is no standard treatment; however, radical surgery is the treatment cornerstone. Our aim was to present the case of a 34-year-old woman with a primary malignant melanoma in the uterine cervix with affectation of the posterior face of the vagina without metastasis. Total infraelevator pelvic exenteration and adjuvant radiotherapy was performed. The patient was under surveillance for 8 years of followup without evidence of local or distant disease. The majority of case reports found suggests radical hysterectomy as the treatment indicated for these patients. Notwithstanding this, survival is very short when patients are treated in this manner. Based on our results and on those reported in the literature, we propose initial treatment with total pelvic exenteration as optimal management for this neoplasia in its initial form.

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Primary Malignant Melanoma of the Uterine Cervix

Abstract: Malignant melanoma is usually misdiagnosed specially in the chronic form. The immunohistochemical study is useful for definite diagnosis. Treatment is not well established, and the disease histogenesis has been controversial for a long time.

Cited by 36 publications

References 22 publications

Sarcomatoid carcinoma of the cervix with foci of malignant melanoma

Sarcomatoid carcinoma of the cervix with foci of malignant melanoma

Unusual primary location of the malignant melanoma, the cervico-vaginal region: 3 cases and literature review

Primary Malignant Melanoma of the Uterine Cervix Treated with Ultraradical Surgery: A Case Report

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