Primary malignant melanoma of the common bile duct

Carstens, Per H.B.; Ghazi, Cyrus; Carnighan, Robert H.; Brewer, McHenry S.

doi:10.1016/s0046-8177(86)80573-1

Cited by 21 publications

(3 citation statements)

References 12 publications

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“…There was no evidence of metastatic lesions and he was alive 6 months after surgery. The second case, published by Carstens et al 6 in 1986 and Wright et al 7 in 1988, describes biliary tract obstruction in a 30-year-old man due to a primary malignant melanoma. A Whipple resection was performed and the primary origin of the tumor was confirmed by immunohistochemistry and electron microscopy.…”

Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the common bile duct: a case report and literature review

González

Moforte

Martín

et al. 2005

Gastroenterología y Hepatología

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Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the common bile duct: a case report and literature review

González

Moforte

Martín

et al. 2005

Gastroenterología y Hepatología

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“…A review of the published literature searched in PubMed, using a series of search strings ('biliary' OR 'bile duct' AND 'primary' AND 'melanoma') with no date limit, revealed that only 15 cases, including the present case, have been reported to date (summarised in Table 1). [10][11][12][13][14][15][16][17][18][19][20][21] This tumour type appears to have a predilection for adult males (male: female ratio, 13:2) and a mean patient age at presentation of 47.9 years (range, 26-67; Table 1). The predominant clinical symptom was found to be jaundice, with the next most commonly reported symptoms being abdominal pain and dark urine.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of primary biliary melanoma with distinct imaging features: a case report and literature review

et al. 2023

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Primary biliary melanoma arises from proliferating melanocytes in the mucosal surface of the bile duct and is extremely rare. Since the vast majority of biliary melanomas represent metastases of cutaneous origin, accurate preoperative diagnosis of melanoma and exclusion of other primary sources are vital in cases involving primary lesions. Although melanomas with pigmented cells have typical signal characteristics, obtaining a non-invasive pre-treatment diagnosis remains difficult, due to their low incidence. Here, the case of a 61-year-old male Asian patient who presented with upper quadrant abdominal pain, swelling and jaundice for 2 weeks, and who was diagnosed with primary biliary melanoma following extensive preoperative blood analyses, computed tomography (CT) and magnetic resonance imaging (MRI), is described. Post-resection immunohistochemistry confirmed the diagnosis and the patient received six chemotherapy cycles of temozolomide and cisplatin, however, progression of multiple liver metastases was observed at the 18-month follow-up CT. The patient continued with pembrolizumab and died 17 months later. The present case of primary biliary melanoma is the first reported diagnosis based on typical MRI features and the exhaustive exclusion of a separate primary origin.

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“…Primary malignant melanoma of the biliary tract has been detected in all parts of the extrahepatic duct system, i.e., involving the bifurcation (confluens) of the large duct (Washburn et al 1995;Gonzalez et al 2001), hepatic and common bile ducts combined (Deugnier et al 1991), the common bile duct (Duval 1908;Shepherd 1908;Zaide 1963;Breatnach et al 1985;Carstens et al 1986;Wright and Brewer 1988;Cohen et al 1990;Zhang et al 1991;Gates et al 1996;Wagner et al 2000;Medina et al 2003;Bejarano Gonzalez et al 2005), and the ampulla of Vater (Duval 1908;Washburn et al 1995;Fléchon et al 2002). Melanoma of the common bile duct may be combined with melanoma in the gallbladder (Zhang et al 1991;Medina et al 2003).…”

Section: Localizations and Clinical Featuresmentioning

confidence: 99%

Primary and Secondary Malignant Melanoma, and Other Melanotic Tumor, of the Hepatobiliary Tract

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Malignant melanoma (MM) is an aggressive malignancy that frequently involves the hepatobiliary tract, due to the frequent metastases to the liver. Therefore, most of malignant melanotic lesions detected in the liver and bile ducts are metastases of skin melanomas. But there is a small group of MM that takes its origin in the hepatobiliary tract, albeit the cell of origin is not yet known, possibly a neural crest cell that homed to this organ during embryogenesis. Primary MM is well documented for extrahepatic bile ducts and the gallbladder, where primary MMs have been described since long. In particular, primary gallbladder MM is a recognized entity with characteristic growth patterns. In contrast, primary hepatic MM is less well defined and numerous cases published in the old literature may be misinterpretations because metastatic disease is difficult to exclude in many cases, because the primary tumor may have been missed or had regressed. A distinct situation is ocular MM which is known to produce liver metastases after a long time delay. There are rare other melanotic tumors that can manifest in the liver, including melanotic progonoma. A tumor related to MM and known to have visceral manifestations is clear cell sarcoma or melanoma of soft parts.

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Primary malignant melanoma of the common bile duct

Cited by 21 publications

References 12 publications

Primary malignant melanoma of the common bile duct: a case report and literature review

Primary malignant melanoma of the common bile duct: a case report and literature review

Diagnosis of primary biliary melanoma with distinct imaging features: a case report and literature review

Primary and Secondary Malignant Melanoma, and Other Melanotic Tumor, of the Hepatobiliary Tract

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