Primary malignant melanoma of the prostate

Liu, Wenying; Sun, Fa

doi:10.1111/j.1442-2042.2009.02418.x

Cited by 12 publications

(6 citation statements)

References 6 publications

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“…Prostate melanoma is primarily diagnosed on transurethral resection (TUR) chips. On urethroscopy, blackish-brown tissue is a classical melanoma finding, as was seen in our case [ 8 , 9 ]. A staging work-up should be done to determine the disease's extent and treatment accordingly.…”

Section: Discussionsupporting

confidence: 66%

Primary malignant melanoma of prostate: a case report

Masood¹,

Sharma²,

Sood³

et al. 2023

Pan Afr Med J

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While primary genitourinary melanomas account for less than 1% of all melanoma cases, prostatic melanoma is extremely uncommon. These patients are challenging to identify, with a dismal prognosis. We reported a 52-year-old male patient who presented with lower urinary tract symptoms in the last one and a half months. The patient underwent Holmium laser enucleation of the prostate, and the histopathology result of the resected specimen showed prostatic melanoma. Investigations for systemic melanoma evaluation were negative, and the patient underwent radical cystoprostatectomy, urethrectomy, and bilateral lymph node dissection. The patient refused chemotherapy, developed lung metastasis shortly after surgery at three months, and succumbed to the metastatic disease with overall survival of 6 months. In conclusion, primary malignant melanoma of the prostate is a very rare disease. The most logical therapeutic strategy is aggressive surgical resection, followed immediately by adjuvant therapy.

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Section: Discussionsupporting

confidence: 66%

Primary malignant melanoma of prostate: a case report

Masood¹,

Sharma²,

Sood³

et al. 2023

Pan Afr Med J

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“…6 Cases of SV metastasis of malignant melanoma have been reported, but with prostate and bladder involvement and other visceral metastasis. 5,7 Meng and colleagues 5 reported a case of hemospermia in a 33-yearold man, revealing multiple metastatic disease including SV, of a malignant melanoma from unknown primary site.…”

Section: Discussionmentioning

confidence: 99%

Seminal vesicle metastasis of cutaneous malignant melanoma : an unusual and challenging presentation.

Kamwa

Mateus

Thanigasalam

et al. 2015

CUAJ

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Malignant melanoma is a tumour, which usually involves skin melanocytes. Involvement of the male genitourinary (GU) system by melanoma is an uncommon and challenging diagnosis. We report the first case of seminal vesicle metastasis from a primary cutaneous melanoma in a 58-year-old man, with hemospermia as the only clinical sign. This case highlights the role of multiparametric magnetic resonance imaging, as a more sensitive assessment to early detect metastatic melanoma in the GU system. The patient underwent a robot-assisted laparoscopic bilateral seminal vesiculectomy, which had good functional and oncological results and is still in complete remission at the 1-year follow-up.

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“…1 Cutaneous melanocytes are normally present scattered along the basal part of the epidermis. Non-cutaneous melanocytes are present in multiple sites of the body including the posterior and anterior regions of the uvea, the conjunctiva, 2 mucosal surfaces such as the nasal and oral cavities, vulva/vagina, anus/rectum and glans penis, 3 the prostate and urethra, [4][5][6] the biliary tract, 7 the cochlea and vestibular labyrinth of the inner ear, the valves and septa of the heart 1 and the meninges. 8 Epidemiological, clinical and morphological features as well as genomic characteristics have been used to define nine melanoma subtypes 9,10 that can be broadly separated into those that are epithelium-associated, which includes mucosal-associated, and nonepithelium-associated melanomas, which include the uveal tract and internal organs.…”

Section: Introductionmentioning

confidence: 99%

Genetic drivers of non‐cutaneous melanomas: Challenges and opportunities in a heterogeneous landscape

Vergara

Wilmott

Long

et al. 2021

Experimental Dermatology

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Non-cutaneous melanomas most frequently involve the uveal tract and mucosal membranes, including the conjunctiva. In contrast to cutaneous melanoma, they often present at an advanced clinical stage, are associated with worse clinical outcomes and show poorer responses to immunotherapy. The mutational load within most noncutaneous melanomas reflects their lower ultraviolet light (UV) exposure. The genetic drivers within non-cutaneous melanomas are heterogeneous. Within ocular melanomas, posterior uveal tract melanomas typically harbour one of two distinct, sets of driver mutations and alterations of clinical and biological significance. In contrast to posterior uveal tract melanomas, anterior uveal tract melanomas of the iris and conjunctival melanomas frequently carry both a higher mutational burden and specific mutations linked with UV exposure. The genetic drivers in iris melanomas more closely resemble those of the posterior uveal tract, whereas conjunctival melanomas harbour similar genetic driver mutations to cutaneous melanomas. Mucosal melanomas occur in sun-shielded sites including sinonasal and oral cavities, nasopharynx, oesophagus, genitalia, anus and rectum, and their mutational landscape is frequently associated with a dominant process of spontaneous deamination and infrequent presence of UV mutation signatures. Genetic drivers of mucosal melanomas are diverse and vary with anatomic location. Further understanding of the causes of already identified recurrent molecular events in non-cutaneous melanomas, identification of additional drivers in specific subtypes, integrative multi-omics analyses and analysis of the tumor immune microenvironment will expand knowledge in this field. Furthermore, such data will likely uncover new therapeutic strategies which will lead to improved clinical outcomes in non-cutaneous melanoma patients.

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Primary malignant melanoma of the prostate

Cited by 12 publications

References 6 publications

Primary malignant melanoma of prostate: a case report

Primary malignant melanoma of prostate: a case report

Seminal vesicle metastasis of cutaneous malignant melanoma : an unusual and challenging presentation.

Genetic drivers of non‐cutaneous melanomas: Challenges and opportunities in a heterogeneous landscape

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