Primary malignant melanoma of meninges: Atypical presentation of subacute meningitis

Nicolaides, Paola; Newton, Richard; Kelsey, Anna

doi:10.1016/0887-8994(94)00155-u

Cited by 36 publications

(43 citation statements)

References 8 publications

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“…In addition, the pathologic appearance of the disease is similar with that of the primary melanocytic tumors (5, 6). The primary issue in the diagnosis of CNS melanoma is the differential diagnosis between the primary and metastatic melanoma.…”

Section: Discussionmentioning

confidence: 56%

“…Primary meningeal melanomatosis is more common in adults than in children, and has various manifestations, including seizures, symptoms and signs of increased intracranial pressure, psychiatric disturbances, cranial nerve palsies, and spinal cord compression (3, 4). Despite the use of computed tomography (CT), contrast-enhanced magnetic resonance imaging (MRI), and cerebrospinal fluid (CSF) cytology, diagnosis of meningeal melanomatosis is challenging because clinical manifestations, radiologic features, and pathologic findings overlap with a wide variety of other conditions (5-9). …”

Section: Introductionmentioning

confidence: 99%

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F-18 Fluorodeoxyglucose PET/CT and Post Hoc PET/MRI in a Case of Primary Meningeal Melanomatosis

et al. 2013

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Primary meningeal melanomatosis is a rare, aggressive variant of primary malignant melanoma of the central nervous system, which arises from melanocytes within the leptomeninges and carries a poor prognosis. We report a case of primary meningeal melanomatosis in a 17-year-old man, which was diagnosed with 18 F-fluorodeoxyglucose (F-18 FDG) PET/CT, and post hoc F-18 FDG PET/MRI fusion images. Whole-body F-18 FDG PET/CT was helpful in ruling out the extracranial origin of melanoma lesions, and in assessing the therapeutic response. Post hoc PET/MRI fusion images facilitated the correlation between PET and MRI images and demonstrated the hypermetabolic lesions more accurately than the unenhanced PET/CT images. Whole body F-18 FDG PET/CT and post hoc PET/MRI images might help clinicians determine the best therapeutic strategy for patients with primary meningeal melanomatosis.

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

F-18 Fluorodeoxyglucose PET/CT and Post Hoc PET/MRI in a Case of Primary Meningeal Melanomatosis

et al. 2013

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“…Primary diffuse meningeal melanomatosis is a rare variant of malignant melanoma of the CNS 4 and can clinically mimic a wide variety of other conditions, including lymphoma, leukemia, acute neurosarcoidosis, metastatic carcinoma, acute disseminated encephalomyelitis (ADEM), subacute meningitis, viral encephalitis, 5 and idiopathic hypertrophic cranial pachymeningitis. 6 The clinical presentation in our patient with bilateral involvement of optic nerves, cognitive disturbances, and signs of peripheral nervous system involvement pointed to the diagnosis of ADEM.…”

Section: Discussionmentioning

confidence: 99%

Primary Diffuse Meningeal Melanomatosis

Zadro¹,

Brinar²,

Barun³

et al. 2010

The Neurologist

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Primary diffuse meningeal melanomatosis can clinically mimic a wide variety of other conditions, including lymphoma, leukemia, neurosarcoidosis, metastatic carcinoma, acute disseminated encephalomyelitis, subacute meningitis, viral encephalitis, and idiopathic hypertrophic cranial pachymeningitis. We report on a young patient with primary diffuse meningeal melanomatosis who presented with papilledema, flaccid paraparesis, and cognitive impairment. The importance of imaging of the whole central nervous system, cerebrospinal fluid analysis, and pathohistological examination is emphasized in making the appropriate diagnosis.

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“…Both more commonly present with acute symptoms suggestive of raised intracranial pressure. Infants with NCM tend to present with acute symptoms, and those who present later tend to have more chronic symptoms and neuropsychiatric presentations, including depression 18,19 and psychosis. 16 Acute presentation in infancy usually involves hydrocephalus and other symptoms of raised intracranial pressure, such as lethargy, irritability, poor feeding, and seizures.…”

Section: Discussionmentioning

confidence: 99%

“…In both NCM and LMM, elevated CSF protein and decreased CSF glucose levels have been noted. 2,19,41 Large pigment-bearing cells can be identified microscopically, and ultrastructural confirmation of these as melanotic by electron microscopy has been used as a diagnostic tool. 2,41 The limited numbers of pediatric patients with NCM/LMM seen in any one center, however large, mean that useful data on therapy in these conditions are difficult to obtain.…”

Section: Discussionmentioning

confidence: 99%