Primary malignant lymphomas of the spleen: A morphologic and immunohistochemical analysis of 17 cases

Abstract

Seventeen cases of primary malignant lymphoma of the spleen (PMLS) were identified among 500 splenectomy specimens showing involvement by Hodgkin's disease or non-Hodgkin's lymphoma. All PMLS represented non-Hodgkin's lymphoma and most of them were of B-cell origin. In two cases PMLS were associated with hamartomas of the spleen (splenomas). Histologic and immunohistochemical studies did not reveal any differences between PMLS and disseminated malignant lymphomas with splenic involvement with regard to morphologic features, immunophenotype, host cell infiltrates, or proliferation activity. The reasons for the infrequent occurrence of primary lymphomas in the spleen may not be sought in a special immunophenotype of PMLS, a vigorous host response in the spleen, or in a lower proliferation activity of splenic lymphomas.

Primarysplenic Large Cell B Lymphoma: Case Report

“…MRI is also a useful tool for identifying and characterizing focal splenic lymphoma [9] . Interestingly, patients with PSL mentioned in literature showed splenomegaly without exception and splenectomy was the method of diagnosis and treatment [10,11] . On the other hand, splenic needle biopsy may provide an adequate diagnosis for PSL without severe complications [12] and can help to make differential diagnosis of a solitary splenic mass such as hemangioma, hamartoma and abscess, as well as metastatic disease [13] .…”

Surgical approach of primary splenic lymphoma: report of a case and review of the literature

“…Common histological appearance refers to the depiction of multiple nodules occupying the white pulp. When advanced, the entire spleen may be replaced by the tumor, especially of the large cell variety [20]. In some cases, notably in follicular small cleaved lymphoma, the spleen may appear normal with neoplastic cells visible only on high power microscopy.…”

Primary splenic lymphoma: Current diagnostic trends

“…PSL is a rare neoplasm of the spleen, probably comprising less than 2% of all the lymphomas[6,7] and 1% of all the non-Hodgkin’s lymphomas[2,8-10]. …”