Primary malignant lymphomas localized in salivary glands

Abstract

Biopsies from 25 patients with primary malignant lymphoma in the salivary region were investigated morphologically and the clinical findings were analysed. Cases showing myoepithelial sialadenitis or Sjögren's syndrome were not included. The tumour was localized in the parotid region in 21 cases and to the submandibular region in four cases. Non-Hodgkin's lymphoma was diagnosed on 21 biopsies and Hodgkin's disease on four: all patients were of stages I or II. The most frequent type of malignant lymphoma was the centroblastic-centrocytic type; sclerosis was found in all but one of these 15 cases. Polymorphic immunocytoma was diagnosed in two cases, centroblastic lymphoma in two cases and immunoblastic lymphoma in two cases. In eight patients, the lymphomas definitely originated in intraglandular lymph nodes; in 10 other patients, the lymphomas might have developed in intraglandular lymph nodes. It was not possible to determine the origin of the lymphoma in the other seven cases. The prognosis was relatively favourable.

Primary salivary gland lymphoma among Japanese: A clinicopathological study of 30 cases

“…These nodes usually contain salivary ducts and acini in the medullary region, a phenomenon probably due to the close relationship between developing glands and lymphoid tissue during embryonic life [26]. Histologically, it is not always possible to define whether salivary gland lymphomas without pre-existing myoepithelial sialoadenitis are true extranodal lymphomas or merely node tumors that invade the glandular parenchyma [13,15]. Schmid et al indicated that only malignant lymphomas of the salivary gland region could be diagnosed as primary salivary gland lymphoma using the following criteria: (1) the lesion contains no lymph nodes and (2) none of the lesions are demarcated by a capsule-like structure similar to an expanded lymph node capsule [13].…”

Malignant lymphoma of the kidney

“…Others postulated that the lymphatics in the renal capsule might be the source of lymphoma, which subsequently invade into the renal parenchyma [27]. In other extranodal organs, lymphoid tissues formed by the chronic inflammation are regarded as the sources for development of malignant lymphoma [5], i.e., Hashimoto's thyroiditis for thyroid lymphoma [28], follicular gastritis for gastric lymphoma [29], chronic sialadenitis for salivary gland lymphoma [30], and so on. Recent reports with adequate roentgenographic information supported the presence of primary lymphoma of the kidney [11], although the presence of lymphoid tissue in or near the lymphoma was not mentioned.…”

Primary Malignant Lymphoma of the Parotid Gland

“…With this in mind, the prognoses from several reviews are shown in Table 7. 2,8,12,35 The impact of histological grade, stage of disease, and presence or absence of an underlying autoimmune disease on clinical outcome is controversial. 2,8,36,37 In our study, the only variable to achieve prognostic significance was the histological grade according to the Working Formulation.…”