Primary malignant amelanotic melanoma in the female genital tract: A report of six cases and a review of the literature

An, Jusheng; Wu, Lingying; Li, Bin; Lu, Haizhen; Li, Ning; Ma, Shaoping

doi:10.1007/s11805-008-0383-x

Cited by 4 publications

(8 citation statements)

References 9 publications

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“…8,9 Since the present case showed strong positivity for vimentin, S-100 and HMB-45 additional immunohistochemistry was not required.…”

Section: 10mentioning

confidence: 85%

“…An occasional series or case reports have been documenting amelanotic melanoma originating exclusively in the vulva and uterine cervix. [2][3][4][5][6][7][8][9] Ragnarsson-Olding reported that 27% of all vulvar melanomas are amelanotic type, however the incidence of cervical amelanotic melanoma is not yet known.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9] Moreover, delayed diagnosis and advanced stage can further increase the difficulty in management. For amelanotic melanoma in the cervix, most authors have recommended radical hysterectomy and if necessary, to obtain clean surgical margins of at least 2 cm.…”

Section: 10mentioning

confidence: 99%

“…However, the prognosis is usually poor, most patients die within 3 years of diagnosis. [7][8][9] Biopsy for the malignant melanoma in cervix has high misdiagnosis rate. Special staining and immunohistochemistry should be resorted to, whenever needed, to reach the diagnosis of amelanotic melanoma as early as possible.…”

Section: -9mentioning

confidence: 99%

“…The absence or rarity of melanin granules in amelanotic melanomas can lead to their misdiagnoses as carcinomas, sarcomas or lymphoma. [2][3][4][5][6][7][8][9] In this context, ancillary immunohistochemistry is of value and the use of vimentin, S-100 and HMB-45 monoclonal antibody is reported to vastly improve the accuracy of diagnosing malignant melanomas. [3][4][5][6][7][8][9] We present a rare case of primary amelanotic melanoma of the cervix, which was initially suspected to be a poorly differentiated malignant tumor with a wide differential diagnosis of carcinoma, sarcoma, lymphoma and amelanotic melanoma but was subsequently correctly diagnosed by immunohistochemistry.…”

Section: Introductionmentioning

confidence: 99%

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Primary amelanotic melanoma of the cervix: case report with review of literature

Duggal

Srinivasan

2010

J Gynecol Oncol

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Primary malignant melanoma of the uterine cervix is a rare neoplasm with poor prognosis. It may be misdiagnosed especially when amelanotic, in which case immunohistochemistry is useful in reaching the diagnosis. We present one such case of a 65-year-old postmenopausal female patient presenting with bleeding per vaginum. Speculum examination revealed an ulcero-proliferative growth involving the cervix. On histopathological examination it was originally suspected to be a poorly differentiated carcinoma or a non-epithelial malignant tumor, but was subsequently correctly diagnosed by immunohistochemical staining with the HMB-45 antibody and S-100 protein.

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“…8,9 Since the present case showed strong positivity for vimentin, S-100 and HMB-45 additional immunohistochemistry was not required.…”

Section: 10mentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: 10mentioning

confidence: 99%

Section: -9mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Primary amelanotic melanoma of the cervix: case report with review of literature

Duggal

Srinivasan

2010

J Gynecol Oncol

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Primary malignant melanoma of the cervix: A comprehensive analysis of case reports in the Chinese population

Yuan

Cai

et al. 2023

Cancer Medicine

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Purpose Malignant melanoma is a tumor generated from the basal melanocytes of human epidermis. Primary malignant melanoma of the cervix (PMMC) is derived from cervical melanocytes. It is an uncommon disease, mostly occurring in perimenopausal women. PMMC has a bad prognosis and lacks a defined protocol or treatment standards. The aim of this study was to analyze the impact of different surgical procedures and different adjuvant treatment modalities on their prognosis and to find risk factors for their prognosis by integrating published case report data based on the Chinese population. Methods and Results This study included 165 patients with PMMC in the Chinese population. We used the Kaplan‐Meier method to build the survival curve, and the log‐rank test to examine the variations among the subgroups. Prognostic factors were examined utilizing the Cox proportional hazards regression model. We found that patients who underwent radical hysterectomy‐based surgery, those who underwent lymphadenectomy, and those who underwent other treatments in addition to surgery had significantly better survival rates. The overall analysis, showed that age, and FIGO Stage II, III, and IV, increased the risk of death. Moreover, radical hysterectomy (RH), total hysterectomy (TAH), lymphadenectomy, and adjuvant therapy were correlated with a decreased mortality risk. Conclusion After summarizing the current data, we recommend radical hysterectomy, and lymphadenectomy treatment for patients with PMMC. For patients who had already undergone surgery, other treatment options had a positive effect on prognosis. For patients who had already undergone surgery, other treatment options had a positive effect on prognosis; therefore patient‐specific treatment options need to be further discussed.

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Primary amelanotic malignant melanoma of cervix masquerading as squamous cell carcinoma presenting with extensive metastases

et al. 2018

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Amelanotic melanoma of cervix is a rare and aggressive neoplasm and only few cases have been reported in the literature. We report a rare case of an amelanotic melanoma of the uterine cervix with extensive metastases and multiple subcutaneous nodules. Due to the unusual site and amelanotic nature of the lesion, chances of misdiagnosis are high and immunohistochemical markers for melanoma help establish the diagnosis. The possibility of metastasis from a primary malignant melanoma of the skin needs to be ruled out. The present case was initially misdiagnosed and treated on the regimen for squamous cell carcinoma, but progressed despite chemotherapy. After a thorough re-evaluation and applying extensive panel of immunohistochemistry, the diagnosis of an amelanotic malignant melanoma of uterine cervix was established.

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Primary malignant amelanotic melanoma in the female genital tract: A report of six cases and a review of the literature

Cited by 4 publications

References 9 publications

Primary amelanotic melanoma of the cervix: case report with review of literature

Primary amelanotic melanoma of the cervix: case report with review of literature

Primary malignant melanoma of the cervix: A comprehensive analysis of case reports in the Chinese population

Primary amelanotic malignant melanoma of cervix masquerading as squamous cell carcinoma presenting with extensive metastases

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