Primary malignancy of seminal vesicle: A rare entity

Primary tumors of the seminal vesicle are extremely rare lesions, and adenocarcinoma is the most common histology found. We report the case of a 54-year-old patient who has consulted with a bladder outlet obstruction and two episodes of initial hematuria for 3 months. Digital rectal examination revealed a hard, palpable mass in the prostate wall. The prostate-specific antigen (PSA), the serum carcinoembryonic antigen and the cancer antigen 125 (CA125) were normal. On imaging, a prostatic abscess, granulomatous prostatitis or a prostatic cancer were highly suspected at first. But the patient was afebrile and PSA was normal. Transrectal ultrasound-guided biopsies of the mass were performed. The pathological examination showed a poorly differentiated adenocarcinoma. Immunohistological analysis was strongly suggestive of adenocarcinoma of the seminal vesicle. At surgical exploration, it was impossible to make cystoprostatovesiculectomy because the tumor was locally advanced. We decided to make hormonal blockage by antiandrogen and five sessions of radiotherapy. Unfortunately, the patient died 5 months later. Adenocarcinoma of the seminal vesicles is a rare diagnosis. We must think in this diagnosis when relatively young patient is presented with dysuria, hematuria or hemospermia and when we found hard palpable mass on digital rectal examination associated to normal PSA level. On histology, specific immunohistochemical markers would be helpful in this differential diagnosis. Actually, surgical excision is the mainstay of the treatment. Radiotherapy and androgen deprivation therapy can be an alternative in locally advanced and metastatic carcinomas.

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“…Ifosfamide and etoposide may be added. The optimal combination of chemotherapeutic drugs is still debated and should be individualized [2].…”

Section: Discussionmentioning

confidence: 99%

“…In 1956, Dalgaard and Giertson [2] established the following criteria for a diagnosis of SVC: 1) The tumor should be a microscopically verified carcinoma, localized exclusively or mainly in the seminal vesicle.…”

Section: Discussionmentioning

confidence: 99%

Primary Seminal Vesicle Adenocarcinoma Presenting as Acute Urinary Retention and Hematuria: A Case Report

Bouassida

Hmida

Mestiri

et al. 2015

World J Nephrol Urol

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“…Of these primary malignant tumors, only couple of cases of PNET of seminal vesicle have been reported so far in the literature. [ 4 5 ] Lower urinary tract symptoms especially hematospermia point to possible seminal vesicle pathology. It is also important to differentiate between primary tumor and a secondary metastatic spread to seminal vesicles, as the former is a localized disease with possibility of cure, while the latter is usually an advanced disease with dismal prognosis.…”

Section: Discussionmentioning

confidence: 99%

Primitive neuroectodermal tumors: Two genitourinary afflictions with varied presentations

2018

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Primitive neuroectodermal tumor (PNET) is a rare disease with high malignant potential. It usually affects the skeletal system. Primary extraskeletal involvement of PNET is uncommon with few reported cases. PNET of the genitourinary system requires a very high index of suspicion for the diagnosis since the presentation of these tumors can be varied. We report two cases of PNET with varied presentations, affecting the genitourinary system.

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“…There are very few cases reported worldwide, approximately fewer than 100 cases ( 86 ). Etiology of this pathology is unclear, but patients present symptoms of obstructive uropathy, hematuria, and hematospermia ( 87 - 89 ). Diagnosis of ASVs is difficult, as they are negative for prostate-specific antigen and prostate-specific acid phosphatase.…”

Section: Introductionmentioning

confidence: 99%

“…Immunophenotype of ASVs are positive for cancer antigen 125 and 7 ( 55 ). Primary diagnostic steps include, DRE identifies as a mass, which requires further examination, and TRUS and biopsy ( 89 , 90 ). MRI, CT with contrast, after histopathology, determine the mass as SVs adenocarcinoma .…”

Section: Introductionmentioning

confidence: 99%

Detecting diseases of neglected seminal vesicles using imaging modalities: A review of current literature

Dagur

Warren

Suh

et al. 2016

IJRM

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Seminal vesicles (SVs) are sex accessory organs and part of male genitourinary system. They play a critical role in male fertility. Diseases of the SVs, usually results in infertility. Diseases of the SVs are extremely rare and are infrequently reported in the literature. We address the current literature of SV pathologies, symptoms, diagnosis, and treatment options. We review the clinical importance of SVs from PubMed. The current imaging modalities and instrumentation that help diagnose SV diseases are reviewed. Common pathologies including, infection, cysts, tumors, and congenital diseases of the SVs are addressed. Many times symptoms of hematospermia, pain, irritative and obstructive lower urinary tract symptoms, and infertility are presented in patients with SV diseases.

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Primary malignancy of seminal vesicle: A rare entity

Abstract: We report a rare case of seminal vesicle malignancy (primitive neuro ectodermal tumor) in a 40-year-old male patient. He was treated with enbloc resection of the tumor and ureteric reimplantation. In view of the rarity of this entity, management of these tumors should be individualized.

Cited by 11 publications

References 5 publications

Primary Seminal Vesicle Adenocarcinoma Presenting as Acute Urinary Retention and Hematuria: A Case Report

Primary Seminal Vesicle Adenocarcinoma Presenting as Acute Urinary Retention and Hematuria: A Case Report

Primitive neuroectodermal tumors: Two genitourinary afflictions with varied presentations

Detecting diseases of neglected seminal vesicles using imaging modalities: A review of current literature

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