Primary malignancies of the hepato-biliary-pancreatic system in organ allograft recipients

Penn, Israel

doi:10.1007/s005340050027

Cited by 12 publications

(10 citation statements)

References 33 publications

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“…The cumulative number of years of follow-up is also unknown, and this makes it difficult to calculate the actuarial risk. 2,6,[19][20][21] In this respect, data from single centers with long-term follow-up have become an important source of information for the incidence and nature of de novo cancers, which can then be compared with surveillance epidemiological end results data. Furthermore, these data can be presented as a standard incident ratio (SIR).…”

Section: See Article On Page 1428mentioning

confidence: 99%

Incidence of de novo cancer and lymphoproliferative disorders after liver transplantation in relation to age and duration of follow-up

2008

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Section: See Article On Page 1428mentioning

confidence: 99%

Incidence of de novo cancer and lymphoproliferative disorders after liver transplantation in relation to age and duration of follow-up

2008

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“…Previous studies showed that the incidence of HCC after kidney transplant is much higher in Asian countries where HBV infection is endemic, when compared with the Western countries. 9,10 However, prophylactic use of antiviral therapy may theoretically suppress the HBV DNA levels and reduce the risk of HCC. 11 In fact, there are only limited data in literature regarding the development and management of HCC after kidney transplantation.…”

Section: Introductionmentioning

confidence: 99%

Hepatocellular carcinoma after kidney transplantation: analysis of Hong Kong Renal Registry

et al. 2014

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Kidney transplant recipients have increased risk of cancers when compared with the general population. Hepatocellular carcinoma (HCC) is extremely important in Asia where hepatitis B virus (HBV) infection is endemic. The aim is to study the epidemiological and clinical aspects of all de novo HCC in our kidney transplant recipients. Moreover, various preventive strategies which may help to optimize the outcome will also be discussed. A retrospective review of all patients who developed HCC after kidney transplantation between May 1972 and December 2011 in Hong Kong, based on the data from Hong Kong Renal Registry. After a follow-up period of 40,246 person-years, 20 patients (males 15: females 5) developed HCC. The annual incidence was 49.7/100,000 persons per year. Among them, 16 were HBV carriers, 2 were hepatitis C (HCV) carriers and 2 had HBV and HCV co-infection. Presence of HBV infection was associated with 78-fold higher risk for HCC development. Majority (85%) were asymptomatic when HCC was diagnosed by ultrasound or alpha-fetoprotein surveillance. All patients diagnosed by surveillance received active treatment while 2/3 of symptomatic patients could only receive symptomatic care and died rapidly. In conclusion, HBV infection is the major etiological factor for HCC development in kidney transplant recipients in HBV endemic areas. Regular HCC surveillance appeared to be able to detect early stage cancers which are amenable to treatment and offer the best hope of cure.

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“…Although immunosuppression is mandatory to prevent graft rejection, the development of de novo malignancies in the long-term course after transplantation is a wellknown risk. 14,15 In our patient, the immunosuppression was composed of a triple combination with steroids, cyclosporine A, and MMF. Organ transplant recipients have a 3-to 4-fold increased incidence of malignancies compared with the incidence in the general population.…”

Section: Discussionmentioning

confidence: 97%

Pancreatic Cancer in Cystic Fibrosis After Bilateral Lung Transplantation

et al. 2006

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Cystic fibrosis (CF) is the most common lethal genetic disease affecting 1 in 2500 white patients. Chronic obstructive lung disease and pancreatic insufficiency are the main clinical manifestations of CF. Lung transplantation has become a treatment option for advanced pulmonary disease during the last decade. On the other hand, there is evidence from large cohort studies that CF and immunosuppression are risk factors for pancreatic cancer. Here, we report the case of an 18-year-old female patient with CF and bilateral lung transplantation who underwent Whipple procedure for pancreatic adenocarcinoma at the age of 12 years. Because of growth retardation, the patient underwent a 2-year period of growth hormone treatment before the diagnosis of pancreatic cancer. This case should sensitize physicians to be aware of the increased risk for pancreatic cancer in CF patients especially in those after lung transplantation with immunosuppression and prolonged survival.

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Primary malignancies of the hepato-biliary-pancreatic system in organ allograft recipients

Cited by 12 publications

References 33 publications

Incidence of de novo cancer and lymphoproliferative disorders after liver transplantation in relation to age and duration of follow-up

Incidence of de novo cancer and lymphoproliferative disorders after liver transplantation in relation to age and duration of follow-up

Hepatocellular carcinoma after kidney transplantation: analysis of Hong Kong Renal Registry

Pancreatic Cancer in Cystic Fibrosis After Bilateral Lung Transplantation

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