Primary lymphoma of the prostate treated with rituximab-based chemotherapy: a case report and review of the literature

Taleb, Amina; Ismaili, Nabil; Belbaraka, Rhizlane; Bensouda, Abdellah; Elghissassi, Ibrahim; Elmesbahi, Omar; Droz, Jean Pierre; Errihani, Hassan

doi:10.4076/1757-1626-2-8875

Cited by 11 publications

(5 citation statements)

References 15 publications

(28 reference statements)

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“…2 These clinical features are significant in assisting the clinical diagnosis of PPL. Previous studies in the literature also reported the presence of prostate tumors and prostate hyperplasia on pelvic CT imaging, 6 which are consistent with the findings in our case. Compared with CT and magnetic resonance imaging (MRI), some researchers believe that ultrasound remains a helpful tool for the diagnosis of PPL.…”

Section: Discussionsupporting

confidence: 93%

Primary prostate lymphoma: A case report and literature review

Wang

Sun

et al. 2019

Int J Immunopathol Pharmacol

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Primary prostate lymphoma (PPL) is rare. This article reports a case of PPL by retrospective analysis of the clinical data and review of the literature, in an attempt to explore the diagnosis, treatment, and prognosis of this rare disease. The present case involves a male patient who came to our hospital for medical consultation of dysuria. Serum prostate-specific antigen (PSA) was not remarkable. Pelvic computed tomography (CT) scan suggested obvious enlargement of the prostate and a tumor in the prostate, but the tumor was not significantly enhanced on contrast-enhanced CT scan. Ultrasound suggested obvious enlargement of the prostate with multiple local low-density echoes and rich blood flow signals inside. Histopathology of prostate biopsy suggested prostate diffuse large B-cell lymphoma (DLBCL). The patient refused chemotherapy but agreed to receive radiotherapy. After radiotherapy, the tumor became smaller and the International Prostate Symptom Score (IPSS) score was reduced. Our experience, together with literature review, suggests that prostate puncture biopsy is an important method for the diagnosis of PPL, and imaging examination can assist the diagnosis. Radiotherapy is able to reduce the tumor volume and relieve the symptoms of urinary tract obstruction, and chemotherapy can help achieve a better therapeutic outcome.

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Section: Discussionsupporting

confidence: 93%

Primary prostate lymphoma: A case report and literature review

Wang

Sun

et al. 2019

Int J Immunopathol Pharmacol

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“…Although the prognosis of primary lymphoma of the prostate was classically considered to be poor, some articles have suggested that prolonged survival could be expected if chemotherapy was administered. Taleb et al reported that combination chemotherapy with rituximab and CHOP was useful for the treatment of diffuse large B cell lymphoma of the prostate [6]. …”

Section: Discussionmentioning

confidence: 99%

Spontaneous Regression of Primary Malignant Lymphoma of the Prostate

Misawa

Nakahara²,

Nishisaka³

2013

Case Reports in Urology

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We herein report a case of primary lymphoma of the prostate, which arose in an 85-year-old male with dysuria. CT and MRI examinations demonstrated a large mass in the prostate. A transrectal ultrasound-guided biopsy of the prostate was performed. The histological examination showed diffuse large B-cell lymphoma. The large lesion in the prostate showed spontaneous regression. Spontaneous regression of primary lymphoma of the prostate has not been reported previously. The spontaneous regression of primary lymphoma of the prostate observed in this patient suggests that observation may represent a viable treatment option following a biopsy that has provided a histopathological diagnosis.

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“… 5 The prostate specific antigen (PSA) level is often within the normal range for non-hodgkins lymphomas. 3 , 6 , 7 , 8 For case reports specifically finding follicular lymphoma of the prostate, only Gorgel et al found a normal PSA of 2.4 ng/ml, with the other two cases both having elevated PSA levels. 8 Nerli et al (2020) presented a 73-year-old male with primary follicular lymphoma with a PSA of 46.83 ng/ml, and similarly Oosterheert et al reported a follicular NHL of the prostate with PSA of 62 ng/ml.…”

Section: Discussionmentioning

confidence: 99%