Primary lymphoma of the pericardium: Report on a „Cured”︁ case and review of the literature

Pavlidis, Nicholas; Elisaf, Moses; Bai, Maria; Tolis, Christos; Papadimitriou, Constantine S.

doi:10.1002/mpo.2950220415

Cited by 13 publications

(9 citation statements)

References 26 publications

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“…In the reviewed cases, ten patients underwent surgery with no evidence of improvement in survival [3,6,9,15,19,23,27,35,38,39]. Prompt anthracycline-based chemotherapy has been administrated in 51% of the reviewed cases [1,3,6,7,8,9,12,17,19,20,25,26,29,30,31,38,39,41], resulting in 61% of complete remission (mean follow-up times 17 months; range 3-40 months). Radiotherapy was delivered to 17% of patients, alone or combined with chemotherapy, with a further improvement in survival [3,17,25,26,34,38].…”

Section: Discussionmentioning

confidence: 96%

“…Primary cardiac lymphoma remains asymptomatic until it produces a mass effect when the tumor obstructs cardiac output or causes local invasion, embolization, or systemic manifestations. Chest pain is the most common symptom occurring in 26% [6,10,18,27,28,29,30,31,38], dyspnea in 20% [7,8,9,28,34,36,37], superior vena caval syndrome in 9% [3,15,17] Chest X-ray is not usually helpful for the detection of cardiac tumor. It can reveal non-specific signs such as pleural effusion and/or cardiomegaly.…”

Section: Discussionmentioning

confidence: 99%

“…Transvenous biopsies under simultaneous fluoroscopic and echocardiographic guidance represent a minimally invasive procedure including leftside samples [8] and provided diagnosis in five patients [8,12,18,20,41]. Pericardial biopsy was performed in four reviewed cases, with a 50% success rate [17,30]. A pericardial window fails to obtain a diagnosis in most cases and therefore should not be performed [7].…”

Section: Discussionmentioning

confidence: 99%

“…It is an extranodal lymphoma involving only the heart and/or the pericardium [5]. We report 3 cases of primary cardiac lymphoma and review 35 cases from the literature [1,2,3,6,7,8,9,10,11,12,15,17,18,19,20,21,22,23,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,41].…”

Section: Introductionmentioning

confidence: 96%

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Primary cardiac lymphoma in immunocompetent patients: a report of three cases and review of the literature

et al. 2002

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Primary cardiac lymphoma is an extranodal non-Hodgkin's lymphoma exclusively located in the heart and/or pericardium, extremely rare in immunocompetent patients, and more frequent in immunodepressed patients. We present 3 retrospectives cases of primary cardiac lymphoma in immunocompetent patients and review 35 cases reported in the literature. Two patients were adults and one was a child. Primary cardiac lymphoma presented with constitutional symptoms in two cases and superior vena caval syndrome in one case. Diagnosis of a tumor mass was made in all cases by transthoracic echocardiography. Primary cardiac lymphoma arose in the heart right chambers in two cases. Histological diagnoses, obtained after thoracotomy, were diffuse large B-cell lymphoma in two cases, and Burkitt's lymphoma in one case. All three cases received chemotherapy, combined with radiotherapy in one patient. Of our patients, 2 are alive and asymptomatic 12 months and 33 months after diagnosis. In conclusion, diagnosis of primary cardiac lymphoma is difficult due to non-specific clinical manifestations and should be considered in patients with a cardiac mass sometimes with pericardial effusion. It is confirmed using transthoracic echocardiography and magnetic resonance imaging and certified using cytology or open biopsy. The only effective treatment is chemotherapy, but prognosis remains poor.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Primary cardiac lymphoma in immunocompetent patients: a report of three cases and review of the literature

et al. 2002

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“…La poliquimioterapia ha sido empleada obteniéndose escasas remisiones completas (8)(9)(10)(11). No obstante, en algunos casos en que se ha podido establecer un diagnóstico precoz la poliquimioterapia intensiva ha permitido mejorar el pronóstico (6,7,12). En algún paciente se ha realizado quimioterapia intensiva seguida de trasplante de progenitores hematopoyéticos de sangre perifé-rica, con buena respuesta (13).…”

Section: Discussionunclassified

Linfoma cardiaco primario: Presentación de dos casos en pacientes inmunocompetentes

Artal

Roure

Ferré

et al. 2002

An. Med. Interna (Madrid)

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INTRODUCCIÓNEl linfoma cardiaco primario (LCP) es una forma muy infrecuente de presentación de linfoma extranodal (1). Los pacientes suelen presentar insuficiencia cardiaca y derrame pericárdico, y con frecuencia se afectan las cavidades cardiacas derechas. Los métodos más sensibles para diagnosticar este tumor son la resonancia magnética y la ecocardiografía transesofágica . Histológicamente los LCPs son, en la mayoría de casos, linfomas B de células grandes difusos (2). El pronóstico es grave debido a la localización del tumor. El virus de Epstein-Barr (VEB) ha sido descrito como agente causal de LCP en pacientes inmunodeprimidos (3). No obstante no se ha demostrado la relación del VEB como agente causal de LCP en pacientes inmunocompetentes.En el presente trabajo se describen las características clíni-cas de dos pacientes inmunocompetentes afectos de LCP. Se ha investigado la presencia de VEB en el tumor mediante hibridación in situ e inmunohistoquímica. CASOS APORTADOSCaso 1: Una mujer de 49 años de edad, sin antecedentes patoló-gicos de interés, presentaba un cuadro de dolor en hipocondrio derecho, síndrome tóxico, episodios sincopales y síntomas de insuficiencia cardiaca de dos meses de evolución. El electrocardiograma mostró un bloqueo auriculoventricular de tercer grado que requirió la implantación de un marcapasos externo. El ecocardiograma demostró la presencia de una masa intracardiaca y de líquido en pericardio que tuvo que ser drenado. Fue intervenida quirúrgicamente observándose un tumor que ocupaba las dos cámaras cardiacas derechas y que infiltraba aorta, arterias pulmonares y parte del tabique interven-33 [0212-7199(2002) RESUMENFundamento: El linfoma cardiaco primario (LCP) es muy infrecuente en pacientes sin alteraciones inmunitarias habiéndose descrito unos 50 casos en el mundo hasta 1996. Su patogenia no se conoce y algunos estudios que han investigado la presencia del virus de Epstein Barr en el tumor en general no lo han demostrado.Casos: Se describen los casos de dos pacientes con LCP. En ambos casos el diagnóstico fue realizado post mortem.Ambos pacientes presentaban un linfoma B de células grandes difuso. En los dos casos se ha identificado la presencia de focos inflamatorios a cierta distancia del tumor. No se ha podido demostrar la presencia de VEB en el tumor.Conclusiones: Los LCPs son tumores de rápido crecimiento con un pronóstico muy desfavorable. El virus de Epstein-Barr no parece desempeñar un papel en la etiopatogenia de estos tumores.

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Primary cardiac lymphoma

et al. 1997

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Primary cardiac lymphoma is a rare entity. We report on the clinicopathological features of 2 patients with primary cardiac lymphomas: one involving the right atrium resulting in intractable right heart failure, and the other involving the pericardium with massive pericardial effusion. In the first patient, sternotomy and surgical biopsy of the tumor were performed to arrive at the diagnosis. In the second patient, CT thorax and transesophageal echocardiography helped to diagnose the pericardial tumor, and cytological examination of the pericardial fluid established the pathological diagnosis of lymphoma. Combination chemotherapy (COPP) was started in both patients. The first patient died on the first day of chemotherapy due to intractable heart failure, while the second attained a partial response to chemotherapy but died of progressive disease 8 weeks later. This is followed by a literature review of 21 patients with primary cardiac lymphoma. In conclusion, the prognosis of primary cardiac tumor remains poor.

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Primary lymphoma of the pericardium: Report on a „Cured”︁ case and review of the literature

Cited by 13 publications

References 26 publications

Primary cardiac lymphoma in immunocompetent patients: a report of three cases and review of the literature

Primary cardiac lymphoma in immunocompetent patients: a report of three cases and review of the literature

Linfoma cardiaco primario: Presentación de dos casos en pacientes inmunocompetentes

Primary cardiac lymphoma

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