Primary Lymphoma of the Breast: Unusual Presentation of Breast Cancer

Sokolov, Tal; Shimonov, Mordechai; Blickstein, Dorit; Nobel, Michael; Antebi, E

doi:10.1080/110241500750008952

Cited by 26 publications

(2 citation statements)

References 15 publications

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“…Le cancer du sein présente cependant quelques particularités dans le cadre de la maladie VIH/sida: il apparaît pour des taux de lymphocytes CD4 inférieurs à 200 cellules par mm 3 , chez des femmes plus jeunes; il est volontiers bilatéral avec une histologie inhabituelle et est plus agressif avec une évolution métastatique précoce et un mauvais pronostic; La prise en charge est souvent la même que celle des patientes séronégatifs quelque soit la localisation lymphomateuse. Actuellement, la majorité des auteurs préconisent une chimiothérapie à base d'Endoxan ® , Oncovin ® et Prednisone ® ou associée à une immunothérapie par anticorps anti-CD20 qui neutralisent les cellules cancéreuses [10]. Un traitement anti-VIH est systématiquement associe, on observe souvent chez les porteurs du VIH une forme de résistance à la chimiothérapie, qui est liée à la présence dans la membrane cellulaire d'une glycoprotéine (gp120), qui agit comme une pompe qui tend à faire sortir la molécule anticancéreuse hors de la cellule.…”

Section: Discussionunclassified

Lymphome malin non hodgkinien du sein et VIH: à propos d’un cas

Meklaa¹,

Kharass²

2017

Pan Afr Med J

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Le lymphome malin non-hodgkinien (LNH) représente 0,5% de tous les cancers du sein. Son diagnostic est essentiellement histologique. Nous rapportons un cas de LMNH du sein chez une patiente de 42 ans et chez qui la sérologie VIH est positive. L’objectif de cet article est de discuter les aspects cliniques, radiologiques et thérapeutiques de cette affection et de souligner l’importance du dépistage du VIH en cas de localisation extraganglionnaire des LMNH.

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Section: Discussionunclassified

Lymphome malin non hodgkinien du sein et VIH: à propos d’un cas

Meklaa¹,

Kharass²

2017

Pan Afr Med J

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“…The affection is often unilateral. In 18% of cases, it is bilateral; it can be simultaneous (12%) or sequential (6%) [8,9]. The mode of revelation is almost always a breast tumor with an inflammatory mastitis [2].…”

Section: Discussionmentioning

confidence: 99%

Primary Breast Lymphoma: Exceptional Lesion with Particular Management

Hadj¹,

Gabsi²,

Goucha³

2016

J Cancer Sci Ther

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Introduction: Non-Hodgkin's primary lymphoma of the breast is a rare entity. These tumors represent 0.04% to 0.52% of malignant breast pathology, 2.2% of extranodal lymphoma and 0.4% of all non-Hodgkin lymphoma. Clinical and radiological aspects show no special characteristics. The diagnosis is based on the presence of a lymphomatous proliferation strongly associated to the breast tissue and the diagnosis of an extra-mammary lymphoma must be removed except the presence of ipsilateral axillary lymphadenopathy.Patients and methods: This is a retrospective study of 9 patients treated for non-Hodgkin's primary lymphoma of the breast. They were collected over a period of 14 years (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013). They interested 1 case of follicular lymphoma, 1 case of large T-cell lymphoma and 7 cases of large B-cell lymphoma. The average age was 50 years, ranging from 30 to 76 years. The sex ratio was 0.11 (1 man/8 women). The median follow-up was 43 months . Six patients were older than 60 years. All the tumors were architecturally diffuse. The overall survival was 100% at one year 60% at 3 years. Seven patients achieved a complete remission after initial treatment; one had relapsed after 2 months. Among the 7 cases of large B cell lymphoma, two cases result from follicular lymphoma's transformation. The average processing time was 17 months. Conclusion:The primary breast lymphoma is often diagnosed late. Treatment should be rapidly implemented. Indeed, the 5-year survival of stage I of the Ann Arbor classification is better than for stage II.

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Bilateral primary lymphoma of the breast: A case report initially diagnosed by FNAC

Maounis¹,

Ellina²,

Papadaki³

et al. 2005

Diagnostic Cytopathology

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Primary lymphoma of the breast (PLB) is a rare disease, representing 0.04-0.5% of all malignant breast neoplasms. We present a patient with bilateral breast involvement by a high-grade diffuse large B-cell lymphoma, which was diagnosed initially by fine-needle aspiration cytology (FNAC). Mammography revealed a diffuse increase in density of the right breast and a large solitary mass on the left breast, suggestive of an inflammatory carcinoma. The patient underwent FNAC and the diagnosis of a non-Hodgkin's lymphoma (NHL) was suggested. Physical examination revealed palpable bilateral axillary lymph nodes but no evidence of concurrent widespread disease. The patient underwent complete staging evaluation. The only positive findings were an elevated lactate dehydrogenase (LDH) and evidence of axillary lymphadenopathy on CT. Excisional biopsy was performed on the left breast. The morphological and immunohistochemical analysis confirmed the diagnosis of a high-grade diffuse large B-cell lymphoma with an immunophenotype suggestive of a germinal center cell origin.

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Primary Lymphoma of the Breast: Unusual Presentation of Breast Cancer

Abstract: Even though primary lymphoma of the breast is rare, there are no laboratory or imaging signs of early diagnosis. Excisional biopsy or Tru-cut biopsy are the only correct methods of diagnosis.

Cited by 26 publications

References 15 publications

Lymphome malin non hodgkinien du sein et VIH: à propos d’un cas

Lymphome malin non hodgkinien du sein et VIH: à propos d’un cas

Primary Breast Lymphoma: Exceptional Lesion with Particular Management

Bilateral primary lymphoma of the breast: A case report initially diagnosed by FNAC

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