Primary Lymphoepithelioma-Like Carcinoma of the Lung in a Child

Curcio, LD; Js, Cohen; Fw, Grannis; Ib, Paz; Chilcote, Robert R.; Lm, Weiss

doi:10.1378/chest.111.1.250

Cited by 29 publications

(19 citation statements)

References 8 publications

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“…Primary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare cancer, with known associations with the Epstein-Barr virus (EBV) [1,2,3,4,5,6,7,8,9,10,11]. Begin et al first described [12] this condition in 1987, and since then there have been 91 cases reported in the literature, including the present series [1,2,3,4,5,6,7,8,9,10,11].…”

Section: Introductionmentioning

confidence: 76%

Computed tomography characteristics of advanced primary pulmonary lymphoepithelioma-like carcinoma

Ooi

Khong

et al. 2003

Eur Radiol

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Our objectives were to document CT features of advanced primary pulmonary lymphoepithelioma-like carcinoma (LELC) and to determine features that may assist differentiation from other non-small cell lung cancers (NSCLC). Imaging and clinical data of all patients with biopsy-proven pulmonary LELC (n=12) were retrieved from a database of all NSCLC patients over a 2-year period. Twenty-five controls were recruited from other inoperable non-LELC NSCLC patients from the database. Pre-treatment CT scans of the thorax of both study and control patients were reviewed for lobe involved; tumour site, borders and size; and pleural, vascular or pulmonary involvement. Presence of lymphangitis carcinomatosis was noted. Lymph node metastasis was characterised as ipsilateral or contralateral enlarged (>1 cm) mediastinal or hilar nodes, or as peribronchovas-cular nodal spread. Differences between the two groups were tested using Mann-Whitney rank-sum test. The LELC tumours were significantly larger (45.67 vs 17.71 cm 2 ) than controls and were closely associated with the mediastinum. There were more LELC tumours with well-defined borders (p<0.001) and fewer with spiculated borders (p<0001) than non-LELC tumours. There was increased peribronchovascular nodal spread (p=0.01) and vascular encasement (p=0.02) in LELC compared with non-LELC tumours. Advanced primary pulmonary LELC has distinct radiological features, and can appear as well-defined tumour closely associated with the mediastinum, with peribronchovascular spread and vascular encasement.

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Section: Introductionmentioning

confidence: 76%

Computed tomography characteristics of advanced primary pulmonary lymphoepithelioma-like carcinoma

Ooi

Khong

et al. 2003

Eur Radiol

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“…Several studies have demonstrated Epstein-Barr virus genome in pulmonary carcinomas with morphologic features of lymphoepithelioma-like carcinoma in Asian pattents [8][9][10][11] and Western populations. 12 We studied Epstein-Barr virus RNA in 78 cases of pulmonary nonlymphoepitheliomalike carcinoma using in situ hybridization methodology in 1992, and found none of them to be positive for Epstein-Barr virus.…”

Section: Discussionmentioning

confidence: 99%

“…7 Pulmonary carcinomas with morphologic features of lymphoepithelioma-like carcinoma have also been reported to harbor Epstein-Barr virus. [8][9][10][11] Most of these reports of Epstein-Barr virus-associated epithelial malignancies were in Asian patients. In contrast, there are few reports demonstrating EpsteinBarr virus infection in pulmonary carcinoma in Western populations.…”

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confidence: 99%

Epstein–Barr virus plays no role in the tumorigenesis of small-cell carcinoma of the lung

et al. 2004

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Epstein-Barr virus infection has been associated with lymphoepithelioma-like carcinoma of the lung in Asian patients. Recently, Epstein-Barr virus proteins or genomic DNAs were detected in pulmonary squamous-cell carcinoma, adenocarcinoma, and undifferentiated small-cell carcinoma in American patients. We studied 23 cases of small-cell carcinoma of the lung for evidence of Epstein-Barr virus infection by in situ hybridization, immunohistochemistry, and polymerase chain reaction methods. Of the 23 cases, 13 cases were primary smallcell carcinoma of the lung and 10 cases were metastatic small-cell carcinoma of the lung to the brain (one case), liver (two cases), and lymph nodes (seven cases). None of the 23 cases was positive for Epstein-Barr virusencoded small nonpolyadenylated RNA (EBER)-1 by in situ hybridization. By immunohistochemistry, eight cases showed focal positivity for Epstein-Barr virus nuclear antigen-1. The positive immunostaining was focal and was observed in tumor cells, vascular endothelial cells, and lymphocytes, suggesting nonspecific staining. None of the 23 cases was positive for the transactivating immediate-early BZLF1 (ZEBRA) and latent membrane protein (LMP-1). Only one case was positive for the BamHI W region and LMP-1 gene by polymerase chain reaction assay. Some tumor cells in the BamHI W region positive case were also positive for Epstein-Barr virus nuclear antigen-1. Our study indicates that rare cases of American small-cell carcinoma of the lung may contain Epstein-Barr virus-infected cells, but it is unlikely that Epstein-Barr virus plays a role in the tumorigenesis of small-cell carcinoma of the lung.

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“…Postoperative chemotherapy with four cycles of carboplatin and etoposide (VP-16) had been used for stage II LELC of the lung in one report [13]. There was another report of induction chemotherapy consisting of 5-fluorouracil, calcium folinate and cisplatin in a child with LELC of the lung resulting in significant tumour reduction [19]. In a series of advanced LELC of the lung treated with palliative chemotherapy comprising 5-fluorouracil and cisplatin, 71.4% showed a partial response and 28.6% had progressive disease [10].…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-like carcinoma of the lung in a patient withsilicosis

Lam²,

Ooi³

et al. 2003

European Respiratory Journal

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Silicosis is an important form of pneumoconiosis, which is caused by significant exposure to crystalline silica. The carcinogenicity of silica, despite traditional beliefs, in relation to lung cancer has been controversial. Lymphoepitheliomalike carcinoma of the lung, an Epstein-Barr virus-associated undifferentiated carcinoma, is a rare entity of pulmonary malignancy, which tends to affect young nonsmoking Asians.The first case of silicosis, initially complicated by pulmonary tuberculosis, which later developed into advanced lymphoepithelioma-like carcinoma of the lung is reported. A combination of 5-fluorouracil, cisplatin and calcium folinate resulted in partial tumour response. Eur Respir J 2003; 22: 383-386.

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Primary Lymphoepithelioma-Like Carcinoma of the Lung in a Child

Cited by 29 publications

References 8 publications

Computed tomography characteristics of advanced primary pulmonary lymphoepithelioma-like carcinoma

Computed tomography characteristics of advanced primary pulmonary lymphoepithelioma-like carcinoma

Epstein–Barr virus plays no role in the tumorigenesis of small-cell carcinoma of the lung

Lymphoepithelioma-like carcinoma of the lung in a patient withsilicosis

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