Primary lung carcinoma in children and adolescents – Clinical characteristics and outcome of 12 cases from the German registry for rare paediatric tumours (STEP)

Mucoepidermoid carcinoma of the bronchus in two children: Case reports

“…MEC of the bronchus are painless, slow-growing tumours which accounts for the often-delayed diagnosis. Common symptoms and signs are those of bronchial obstruction and recurrent infections, and include cough, dyspnoea, fever, wheeze, stridor, persistent pneumonia not responding to antibiotics, haemoptysis and clubbing [ 2 , 4 , 5 ]. It may also present as deterioration in a child already known to have a chronic respiratory illness [ 6 ].…”

“…It may also present as deterioration in a child already known to have a chronic respiratory illness [ 6 ]. Delayed diagnosis is common, spanning many months to years [ 2 , 5 ]. There is no clear sex predilection [ 2 ].…”

“…Furthermore, when bronchoscopic resection is done, active surveillance with repeat bronchoscopies is required. This would not be an ideal option in a low resource setting with poor access to bronchoscopy [ 5 ].…”

“…Paediatric MEC has a good prognosis. In a German series, survival was 100% at 3 years [ 5 ]. However, there have been few reported deaths among children with high grade tumours [ 2 ].…”

High-grade pulmonary mucoepidermoid carcinoma supplied by the pulmonary artery and vein in a 6-year-old child: a case description and literature analysis

“…Primary pulmonary mucoepidermoid carcinoma (PMEC) originates from ductal epithelial cells in the submucosa of the trachea and bronchus and accounts for fewer than 1% of all primary lung malignant tumors (1). PMEC is also a primary lung cancer in children but extremely rare.…”