2011
DOI: 10.5021/ad.2011.23.4.515
|View full text |Cite
|
Sign up to set email alerts
|

Primary Localized Cutaneous Nodular Amyloidosis Following Local Trauma

Abstract: Primary localized cutaneous nodular amyloidosis (nodular amyloidosis) is a rare and distinct type of amyloidosis, in which amyloid L deposition is limited to the skin and typically manifested as a tumefactive nodule on the acral sites. However, the definite cause of nodular amyloidosis is still unknown. Although it is relatively well known that the amyloid deposits in nodular amyloidosis originate from immunoglobulin light chains secreted by local plasma cells, traumatic injury to the skin has rarely been reco… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

1
17
0

Year Published

2014
2014
2021
2021

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 14 publications
(18 citation statements)
references
References 16 publications
1
17
0
Order By: Relevance
“…The causal relationship between the cat scratch and NPLCA in our patient remains unclear. While trauma-induced amyloidosis has been recognised in papular and macular amyloid, a few case reports indicate a similar association with nodular amyloidosis 9–11. In our case, lack of inflammation or infection at the time of the cat scratch makes Bartonella henselae and cowpox infections unlikely.…”
Section: Discussionsupporting
confidence: 50%
See 1 more Smart Citation
“…The causal relationship between the cat scratch and NPLCA in our patient remains unclear. While trauma-induced amyloidosis has been recognised in papular and macular amyloid, a few case reports indicate a similar association with nodular amyloidosis 9–11. In our case, lack of inflammation or infection at the time of the cat scratch makes Bartonella henselae and cowpox infections unlikely.…”
Section: Discussionsupporting
confidence: 50%
“…Quoted progression rates of NPLCA to systemic amyloidosis vary significantly. Earlier studies suggest a rate of 50%,9 while more recent studies suggest closer to 7% 3. Although there is no consensus on screening and long-term follow-up of NPLCA for systemic involvement, imaging studies including CT scanning and Serum amyloid P component (SAP) scintigraphy have been suggested.…”
Section: Discussionmentioning
confidence: 99%
“…Although local trauma has rarely been reported to precede development of PCNA, it is not clear if any of these few cases had coexistent psoriasis. It seems possible that foreign material persisting in the soft tissues from the original injury could act as an antigenic target for B‐cell antibody production.…”
Section: Reportmentioning
confidence: 95%
“…PCNA is considered the rarest form of cutaneous amyloidosis compared with the other 2 types, macular amyloidosis and lichen amyloidosis. 2 , 3 , 4 The fibrils of amyloid in PCNA are composed of immunoglobulin light chains of either kappa and/or lambda type, called “protein AL” and do not differ from those seen in primary systemic amyloidosis and in multiple myeloma. 5 , 6 Unlike in the more common forms such as macular and lichen amyloidosis where the amyloid is formed by degenerating keratinocytes, monoclonal plasma cells in PCNA produce and secrete the immunoglobulin kappa and lambda light chains through an unknown mechanism.…”
Section: Discussionmentioning
confidence: 99%