Primary localized amyloidosis of the uterine cervix during pregnancy

Y, Takimoto; Kogiku, Ai; Konda, Eri; Samoto, Takashi; Ishihara, Misa; Yamashita, Taro

doi:10.1111/jog.14218

Cited by 2 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of them, the majority is in localized form. Affected sites were described as uterus, vagina, and cervix [5,7,8]. Existing literature suggests uterine (endometrial or myometrial) amyloidosis is a rare condition.…”

Section: Discussionmentioning

confidence: 99%

“…Amyloid deposition confined to a site may be associated with several endocrine organs or tumors, taking its origin from the relevant hormones or local protein precursors [ 2 ]. Localized uterine amyloidoses have also been described in malignancy- or pregnancy-associated fashion [ 5 , 6 ]. In our literature search on uterine amyloidoses associated with systemic amyloidosis, as a rare site of involvement compared to other organs, we have identified five cases only.…”

Section: Discussionmentioning

confidence: 99%

“…AA amyloidosis was found in 8.6% of 2246 patients with FMF in a study conducted in Turkey [4]. Gynecological amyloidosis has also been documented, albeit rarely [5][6][7][8][9][10][11][12][13]. The majority of reported cases were localized amyloidoses [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Gynecological amyloidosis has also been documented, albeit rarely [5][6][7][8][9][10][11][12][13]. The majority of reported cases were localized amyloidoses [5,6]. Uterine amyloidosis associated with systemic amyloidosis has been described in a few cases, mostly comprised of primary amyloidosis (AL), whereas uterine AA amyloidosis has been reported just in one case who had RA [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Menorrhagia due to uterine amyloidosis in familial Mediterranean fever: case-based review

2020

View full text Add to dashboard Cite

Amyloidosis is described by the deposition of misfolded proteins in the tissues. Amyloidoses are classified into two as systemic and localized. Out of the systemic forms, AL (light chain) amyloidosis is the most prevalent type; however, amyloid A (AA) amyloidosis is more frequently encountered in the rheumatology practice. AA amyloidosis stands out as a major complication of familial Mediterranean fever (FMF). Splenic and renal involvement is more likely in FMF-associated systemic amyloidosis. The involvement of thyroid and adrenal glands has also been described, although infrequently. Amyloidoses have a heterogeneous plethora of clinical manifestations, with certain phenotypes associated with specific amyloid forms. Gynecological amyloidosis is a rare condition. Uterine involvement may occur in a localized fashion or may also arise as a part of systemic involvement, albeit at a lesser ratio. Several cases of uterine AL amyloidosis have been documented so far as an organ involvement in systemic AL amyloidosis. On the other hand, uterine amyloidosis associated with AA amyloidosis has been described merely in one case with rheumatoid arthritis (RA). Here, we presented a 40-year-old female patient with FMF known for 38 years who underwent splenectomy and hysterectomy due to massive splenomegaly, deep anemia, and persistent menometrorrhagia. Histological examinations of materials revealed uterine and splenic AA amyloidosis. This case report is first-of-its-kind to describe FMF-associated uterine AA amyloidosis and also provides a discussion of possible mechanisms of amyloidosis-induced uterine bleeding.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%