Primary liver carcinoma.Autopsy study of 60 cases

Patton, Roy Β.; Horn, Robert C.

doi:10.1002/1097-0142(196406)17:6<757::aid-cncr2820170611>3.0.co;2-9

Cited by 110 publications

(24 citation statements)

References 5 publications

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“…It seems that the tumour may be associated with any type of cirrhosis and in some reports it has been predominantly of the fatty or alcoholic variety (eg, Parker, 1957;Eppstein, 1964). Our findings are similar to those of most recent observers who describe liver cancer as a complication predominantly of coarse multilobular cirrhosis (Gall, 1960;Miyai and Ruebner, 1963;Sagebiel, McFarland, and Taft, 1963;Patton and Horn, 1964;San Jose, Cady, West, Chomet, and Zimmerman, 1965). Post-hepatitic and post-necrotic varieties may be recognized, but in our experience this subdivision was sometimes uncertain on morphological grounds, while the clinical history was usually uninformative.…”

Section: Discussionsupporting

confidence: 87%

Incidence of primary carcinoma of the liver in the west of Scotland between 1949 and 1965.

Manderson¹,

Patrick²,

Peters³

1968

Gut

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Section: Discussionsupporting

confidence: 87%

Incidence of primary carcinoma of the liver in the west of Scotland between 1949 and 1965.

Manderson¹,

Patrick²,

Peters³

1968

Gut

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“…Moreover, the incidence of intrahepatic metastasis correlated well with the frequency of vascular invasion. The reported incidence of tumor thrombi in intrahepatic vessels in HCC ranges from 47.6 to 91.8% [14,15]. In reports that described tumor thrombosis of both the portal and hepatic venous systems, the incidence in the portal system varied from 23.9 to 90.2% and in the hepatic venous system from 3.7 to 15.2% [5,[15][16][17].…”

Section: Discussionmentioning

confidence: 99%

Intrahepatic metastases in hepatocellular carcinoma: the role of the portal vein as an efferent vessel

et al. 1996

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The mechanism and pathogenesis of the high frequency of intrahepatic metastasis in hepatocellular carcinoma (HCC) has not yet been elucidated. Two hundred and thirty one tumors (< or = 5 cm in diameter) of resected specimens of HCC were examined for the relationship between mode of tumor spread and tumor size. Efferent vessels in HCC were identified by direct injection of radiopaque material into the tumor in 23 resected liver specimens selected at random from the 231 tumors. The most frequent site for tumor spread in HCC was capsular invasion followed by extracapsular invasion, vascular invasion, and finally intrahepatic metastasis. There was a strong statistical correlation between the presence of intrahepatic metastasis and the frequency of vascular invasion (correlation coefficient = 0.998). Radiopaque material injected directly into 23 resected tumors entered only the portal vein in 17 tumors and into both the portal and hepatic veins in six tumors. In all eight patients with unresectable lesions, radiopaque media injected percutaneously into tumor nodules flowed only into the portal vein. These findings suggest that tumor spread in HCC progresses from capsular invasion to intrahepatic invasion and that the portal vein may act as an efferent tumor vessel.

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“…It might be argued that the frequency and seriousness of the recurrences were approximately predictable from what is already known about the highly unfavorable natural history of primary hepatic malignancies (Berman 1959, Lawrence et al 1966, Patton & Horn 1964. However, there is the possibility that the metastatic growth may actually have been accelerated as a consequence of the immunosuppressive therapy in the patients who were evidently unknowingly left with residual neoplasm.…”

Section: Daysmentioning

confidence: 99%