Primary Leptomeningeal Melanoma

Allcutt, D; Michowiz, Shalom; Weitzman, Sheila; Becker, Laurence E.; Blasér, Susan; Hoffman, Harold J.; Humphreys, Robin P.; Drake, James M.; Rutka, James T.

doi:10.1097/00006123-199305000-00004

Cited by 9 publications

(15 citation statements)

References 44 publications

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“…Primary leptomeningeal melanoma has been described as ocurring in a number of different forms. All forms of leptomeningeal melanoma are uncommon in children [1,3,4]. Acute presentation in infancy usually involves hydrocephalus and other symptoms of raised intracranail pressure, such lethargy, iritability, poor feeding and seizures [1,3,[5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…All forms of leptomeningeal melanoma are uncommon in children [1,3,4]. Acute presentation in infancy usually involves hydrocephalus and other symptoms of raised intracranail pressure, such lethargy, iritability, poor feeding and seizures [1,3,[5][6][7][8]. The most commom age at presentation is on 0-24 months [1,3].…”

Section: Discussionmentioning

confidence: 99%

“…Since the first description by Virchow in 1859, approximately 230 cases of the prymary leptomeningeal melanoma have been reported [2,3]. A population study in Norway covering a 30-year period identified six definite casesan incidence of 0.005 new cases per year [4].…”

Section: Introductionmentioning

confidence: 99%

“…Aproximately 75% of patients with primary leptomeningeal melanoma lack any significant concomitant lesion [5]. The typical neurological manifestations of leptomeningeal melanoma include seizures, psychiatric disturbances, and symptoms and signs of raised intracranial pressure secundary to hydrocephalus [3,[6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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A Child with Primary Leptomeningeal Melanoma

Dutra¹,

Rezende²,

Morato³

et al. 2020

COR

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Primary malignant melanoma of the meninges is an exceedingly rare neoplasm. Usually its symptoms include raised intracraneal pressure resulting from hydrocephalus seconday to tumoral obliteration of cisternal basal cisterns, but the passage of time from initial symptomalogy to diagnosis is frequently delayed. A 12-year-old male with primary letomeningeal melanoma is reported. At the beginning, he presented with vomiting, headache, complex seizures, fever four months before the admission in the hospital where progressive loss of consciouness after admission. Lumbar puncture reveled high protein level, normal glucose level and 50 leucocytes/mm3 with 86% polymorphic cells. Magnetic ressonance imaging of the brain was referred and in T1-weighted images revealed a diffuse enhancement of the leptomeninges on right frontal cortical. An open brain biopsy trough was performed, after exclusion of the infectious nervous system disease. Histological examination revealed massive infiltration of meninges with brown tumor cells. These cells stained positive for HMB-45, S-100 protein and vimentin. The patient received post operative radiation therapy, but died after three months of the diagnosis with septic shock and epileptical status

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Child with Primary Leptomeningeal Melanoma

Dutra¹,

Rezende²,

Morato³

et al. 2020

COR

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“…Other leptomeningeal melanomas have rarely been found outside of the CNS, particularly in the lungs [28], liver [29] and peritoneum. The last location has often been associated with VP shunting, and the shunt itself has been presumed to be seeding the abdomen [30]. …”

Section: Discussionmentioning

confidence: 99%

Primary Pineal Malignant Melanoma

Bookland

Anderson²,

Biser-Rohrbaugh

et al. 2007

Pediatr Neurosurg

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Primary pineal malignant melanomas are a rare subset of primary central nervous system melanomas. This report presents the case of a 20-year-old female patient with a primary pineal region malignant melanoma who underwent endoscopic biopsy and adjuvant therapy. Her treatment consisted of stereotactic radiation to the pineal tumor, conventional whole-brain radiation and Temodar® for the disseminated disease. She required a ventriculo-peritoneal shunt for refractory ICP problems. This report details the clinical features of the case and summarizes the literature on a rare but aggressive neoplasm.

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Melanozytäre Nävi und maligne Melanome

Garbe

Pädiatrische Dermatologie

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Primary Leptomeningeal Melanoma

Cited by 9 publications

References 44 publications

A Child with Primary Leptomeningeal Melanoma

A Child with Primary Leptomeningeal Melanoma

Primary Pineal Malignant Melanoma

Melanozytäre Nävi und maligne Melanome

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