Primary leptomeningeal anaplastic oligodendroglioma with a 1p36–19q13 deletion: Report of a unique case successfully treated with Temozolomide

Michotte, Alex; Chaskis, Cristo; Sadones, Jan; Veld, Peter In’t; Neyns, Bart

doi:10.1016/j.jns.2009.08.047

Cited by 29 publications

(25 citation statements)

References 15 publications

(18 reference statements)

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“…5 Although calcification is characteristic of intracerebral oligodendrogliomas, it is infrequently reported in diffuse leptomeningeal oligodendrogliomatosis. 2,6 Elevated CSF protein is common among reported cases, but CSF cytology is almost uniformly negative, as it was in this case. 1,2 This suggests that tumor cells spread centrifugally along the meninges rather than via dissemination in the CSF.…”

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confidence: 49%

“…1 However, approximately one-third of tumors progress to anaplasia, leading to death months to years after diagnosis. 1,6 The presence of mitoses on biopsy, as seen in our patient, predicts shorter survival. 1 Dramatic clinical and radiologic improvement has been reported in a patient with anaplastic primary leptomeningeal oligodendrogliomatosis and 1p19q codeletion who was treated with temozolomide.…”

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confidence: 61%

“…1 Dramatic clinical and radiologic improvement has been reported in a patient with anaplastic primary leptomeningeal oligodendrogliomatosis and 1p19q codeletion who was treated with temozolomide. 6 Our patient died shortly after starting temozolomide and radiation therapy. Although the 1p19q codeletion is associated with better overall survival for patients with intracerebral oligodendrogliomas, a similar relationship has not been observed in diffuse leptomeningeal oligodendrogliomatosis.…”

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confidence: 82%

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Diffuse anaplastic leptomeningeal oligodendrogliomatosis mimicking neurosarcoidosis

et al. 2013

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Diffuse leptomeningeal oligodendrogliomatosis is a rare, frequently fatal CNS malignancy that most often affects children.1 Although potentially treatable with chemotherapy and radiation, the radiologic findings are nonspecific and pathologic confirmation of the diagnosis is difficult. We describe an adult patient whose initial presentation mimicked neurosarcoidosis. Despite extensive imaging abnormalities, 3 biopsies were required before the diagnosis of diffuse leptomeningeal oligodendrogliomatosis was confirmed.A 54-year-old woman presented with a 1-year history of progressive headache, left eye visual disturbance, and mild distal lower extremity weakness. Head and spine MRI revealed optic chiasm enlargement, diffuse nodular leptomeningeal enhancement with communicating hydrocephalus, and nodular enhancement of the cauda equina (figure 1, A-E). CSF protein was elevated (510 mg/dL) with 6 nucleated cells and no oligoclonal bands. CSF cytology and extensive testing for infectious etiologies including tuberculosis were negative. Lumbar leptomeningeal biopsy showed fibrotic arachnoid with minimal chronic lymphocytic inflammation. Empiric prednisone (20 mg daily) was initiated.The patient presented 3 months later with seizures and worsening mental status. Head and spine MRI revealed progression of the enhancing leptomeningeal process. A right ventriculoperitoneal shunt was placed. Conjunctival biopsies, serum angiotensin converting enzyme, and CT of the chest, abdomen, and pelvis were unremarkable. Repeat biopsy of the lumbar leptomeninges and cauda equina again showed fibrosis with minimal chronic inflammation. The

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confidence: 82%

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Diffuse anaplastic leptomeningeal oligodendrogliomatosis mimicking neurosarcoidosis

et al. 2013

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“…Leptomeningeal oligodendrogliomas are thought to arise from heterotopic nests of glial tissue within the subarachnoid space [1] . They are extremely rare; only 13 cases (including this report) have been reported, and were summarized by Michotte et al [2] . Several cases of patients with diffuse leptomeningeal disease and a small, discrete, parenchymal nodule have been reported [3][4][5][6] .…”

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confidence: 82%

Primary Diffuse Leptomeningeal Oligodendroglioma

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Blaivas³

et al. 2010

Pediatr Neurosurg

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“…Le témozolomide à doses conventionnelles par voie orale pourrait également présenter un intérêt dans des MN de gliomes de l'adulte [28], de mélanome, de médulloblas-tomes [20] ou dans la gliomatose leptoméningée primitive diffuse [21]. Les résultats d'études de phase II pédia-triques comprenant du témozolomide dans les rechutes de tumeurs cérébrales ou d'autres pathologies sont en attente.…”

Section: La Chimiothérapie Systémiqueunclassified