Primary Leiomyosarcoma of the Oral Cavity: A Case Report and Review of the Literature

Fasanmade, Adekunmi; Barrett, A.W.; Newman, Laurence; Hyde, NC

doi:10.1177/229255030201000302

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2013

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“…There is no age and sex predilection. [20] Histologically LMS typically displays spindle cells with abundant cytoplasm and centrally placed blunt ended cigar shaped nuclei of varying sizes. Multinucleated giant cells are common.…”

Section: Discussionmentioning

confidence: 99%

Leimyosarcoma of the buccal mucosa and review of literature

Nagpal

Prabhu

Shah³

et al. 2013

J Oral Maxillofac Pathol

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Leiomyosarcoma (LMS) is an uncommon malignant spindle cell tumor of the head and neck region. The occurrence is particularly rare in the buccal mucosa of the oral cavity. It is a rapidly growing tumor with aggressive behavior and poor prognosis. Method: This article presents a rare case of primary leimyosarcoma of the buccal mucosa in a 35 year old female and retrospective analysis of primary oral LMS published in the English literature since past 20 years is done. Diagnosis was confirmed by immunohistochemistry profile showing positivity for vimentin, smooth muscle actin (SMA), high proliferative index displayed by Ki-67, focal positivity for pan-CK and negativity for S-100. Conclusion: Based on the presence of malignant spindle cells showing positivity for vimentin and SMA, a diagnosis of leiomyosarcoma was made.

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Section: Discussionmentioning

confidence: 99%