Primary leiomyosarcoma of the omentum presenting as an ovarian carcinoma, case report and review of the literature

Barel, Oshri; Qian, C.; Manolitsas, Tom P.

doi:10.1016/j.gore.2016.07.002

Cited by 5 publications

(5 citation statements)

References 11 publications

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“…The most common presenting symptom was abdominal mass followed by pain abdomen similar to the present case. Ascitis was also reported in few cases [2,3,6]. Our patient did not have ascitis.…”

Section: Discussionsupporting

confidence: 59%

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Primary Omental Leiomyosarcoma: A Rare Case Report

Bhandari

Jadhav

Patil

et al. 2017

Trop J Pathol Microbiol

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Primary leiomyosarcoma of greater omentum is rare and mimics gastrointestinal stromal tumor (GIST) due to their common origin. A 65 years old male presented with a large mass per abdomen of one year duration. Imaging findings were suggestive of extra-gastrointestinal stromal tumor (E-GIST) arising from greater omentum. The mass was excised. On microscopy, the diagnosis of leiomyosarcoma and E-GIST were considered. The tumor cells showed immunoreactivity for smooth muscle actin, muscle-specific actin, heavy-caldesmon and desmin and were immunonegative for CD117, DOG1 and CD34, hence confirming primary leiomyosarcoma of greater omentum. We present this case for its rarity.

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Section: Discussionsupporting

confidence: 59%

“…Most of these cases originated from the greater omentum. These tumors are generally seen in the middle age [2,3]. These tumors can mimic other tumors like gastrointestinal stromal tumors (GIST) due to their common origin from mesenchymal stem cells [4].…”

Section: Introductionmentioning

confidence: 99%

Primary Omental Leiomyosarcoma: A Rare Case Report

Bhandari

Jadhav

Patil

et al. 2017

Trop J Pathol Microbiol

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“…Their etiological factors are still unknown. In a review of the literature, Fagkrezos et al reported 54 cases of extra-gastrointestinal stromal tumors [ 7 ], Barel et al reported 27 cases of leiomyosarcoma [ 8 ], and Hashimoto et al reported 19 cases of liposarcoma of the greater omentum [ 9 ]. According to these reports, the preoperative diagnosis of primary omental tumor is difficult because of its rarity, and thus, the diagnosis is usually made postoperatively.…”

Section: Discussionmentioning

confidence: 99%

Neuroendocrine tumor arising from the greater omentum treated with laparoscopic tumor resection: a case report

et al. 2021

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Background Primary omental tumors are extremely rare. Herein, we report the first case of a primary omental neuroendocrine tumor (NET). Case presentation A 59-year-old woman was referred to our hospital for the treatment of an 18-mm tumor located at the ventral side of the duodenum. No other tumor was detected. The preoperative imaging diagnosis was omental tumor. A laparoscopic tumor resection was performed. Histopathological examination revealed that the tumor consisted of cuboidal cells with eosinophilic, granular cytoplasm showing trabecular or ribbon architecture. No other component was seen. The mitotic count was of 5 per 10 high-power fields. Immunohistochemical staining was positive for chromogranin A, synaptophysin, and CD56. Her Ki-67 index was 5%. These results led to the diagnosis of grade 2 omental NET. The patient was discharged on the 3rd postoperative day without any complications and did not develop any recurrence for 3 years. Conclusions We encountered a very rare case of omental NET. Complete resection is recommended with minimally invasive surgery for the diagnosis of NET.

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“…Abdominal leiomyosarcomas have been rarely reported since Hirota et al first described GISTs with c-kit mutations [1]. One such study is that by Barel et al who reported a case involving primary leiomyosarcoma of the omentum and reviewed 27 other cases previously published in the literature [4]. Moreover, lesser omental leiomyosarcomas are even more infrequent with only three cases being identified using a PubMed search with the keywords “lesser omentum” and “leiomyosarcoma.” However, all three reports did not include c-kit immunostaining, which would help distinguish leiomyosarcoma from GIST [5–7].…”

Section: Discussionmentioning

confidence: 99%

“…In a summary of 27 reports of primary omental leiomyosarcoma by Barel et al, 11 cases died during follow-up. Although the true prognosis for lesser omental leiomyosarcoma is unknown, it is likely to be poor [4]. Although the apparent prognosis for lesser omental leiomyosarcoma has remained unknown, the possibility of poor prognosis has been suggested.…”

Section: Discussionmentioning

confidence: 99%

First Account of Primary Leiomyosarcoma of the Lesser Omentum since Establishment of c-Kit Mutations in Gastrointestinal Stromal Tumors

Saijo

Sato

Handa

et al. 2019

Case Reports in Surgery

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Background Primary omental leiomyosarcoma is an extremely rare type of tumor. Leiomyosarcomas originating from the lesser omentum have not been reported since immunohistochemical staining for c-kit has been used for the diagnosis of mesenchymal abdominal tumors. They are yet to be reported since gastrointestinal stromal tumors were categorized. Here we reported a case of successful resection of a lesser omental leiomyosarcoma. Case Presentation A 71-year-old man underwent ultrasonography at the outpatient clinic through which an upper abdominal tumor was identified. Following computed tomography and endoscopy, a 4.5 cm submucosal tumor in the lesser curvature of the stomach was highly suspected. A laparoscopic partial resection of the stomach was performed. Histopathological examination revealed the tumor to be a leiomyosarcoma arising from the lesser omentum that did not invade the stomach. Immunohistochemical staining showed that the tumor was negative for CD34, c-kit, and S-100 and positive for desmin and α-smooth muscle actin. No recurrence had been observed 1 year after surgery without adjuvant chemotherapy. Conclusions Primary lesser omental leiomyosarcoma, which is difficult to diagnose before surgery given the location of the primary tumor in the lesser omentum, has rarely been reported. Considering the high possibility of malignancy, close observation is essential.

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Primary leiomyosarcoma of the omentum presenting as an ovarian carcinoma, case report and review of the literature

Cited by 5 publications

References 11 publications

Primary Omental Leiomyosarcoma: A Rare Case Report

Primary Omental Leiomyosarcoma: A Rare Case Report

Neuroendocrine tumor arising from the greater omentum treated with laparoscopic tumor resection: a case report

First Account of Primary Leiomyosarcoma of the Lesser Omentum since Establishment of c-Kit Mutations in Gastrointestinal Stromal Tumors

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