Primary Leiomyosarcoma of the Liver

Wilson, Samuel E.; Braitman, Howard E.; Plested, William G.; Longmire, William P.

doi:10.1097/00000658-197108000-00009

Cited by 24 publications

(12 citation statements)

References 4 publications

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“…In the present study, the second most common site of EBV-associated SMTs in AIDS patients were the lung, liver, vocal cord, abdominal wall and adrenal gland, which are rarely observed in non-HIV-infected patients (19,20). These observations are consistent with those of three recent reviews (6,9,10).…”

Section: Discussionsupporting

confidence: 93%

Epstein-Barr Virus-associated Smooth Muscle Tumors in AIDS Patients: A Largest Case (Series)

2014

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This study aimed to determine the outcomes of Epstein-Barr virus (EBV)-associated smooth muscle tumors (SMTs) in AIDS patients at King Chulalongkorn Memorial Hospital, Bangkok, Thailand, treated from 2001-2011. Of the 17 patients, there were five men with a median CD4 count of 26 cells/μL. Eight and nine patients had single and multiple sites, respectively. The most common site was the cranial epidura (58.8%). All patients had EBV within the tumor. Seven patients underwent surgery. The median follow-up was one year. The mortality rate was 41.2%. All patients with undetectable HIV viremia survived. This is the largest case series regarding EBV-associated SMTs in AIDS patients with a long follow-up period.

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Section: Discussionsupporting

confidence: 93%

Epstein-Barr Virus-associated Smooth Muscle Tumors in AIDS Patients: A Largest Case (Series)

2014

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“…Furthermore, intracranial metastasis of leiomyosarcoma is rare [15,16]. To date, there have been no reported liver metastases in AIDS cases [17,18]. Most SMTs are locally invasive even in immunosuppressed patients [19].…”

Section: Discussionmentioning

confidence: 99%

“…Metastatic leiomyosarcomas in the liver are also rare but are probably more common than primary hepatic leiomyosarcomas [18]. To date, there have been no reports of metastatic leiomyosarcomas in the liver in patients with AIDS [17].…”

Section: Discussionmentioning

confidence: 99%

Epstein-Barr Virus Infection-Associated Smooth-Muscle Tumors in Patients with AIDS

Suankratay¹,

Shuangshoti²,

Mutirangura³

et al. 2005

Clinical Infectious Diseases

143

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“…An additional 11 patients were further excluded from OS analysisduetothelackoftumorsize [11][12][13][14][15][16]andtreatment modality description [14,17,18]. The median OS for the 84eligiblepatientswas19months(range0-181months),with survival rates at 1, 2, and 5 years after initial intervention being61.2,41.1,and14.5%,respectively.…”

Section: Overall Survivalmentioning

confidence: 99%

Primary Hepatic Leiomyosarcoma in Adults: Analysis of Prognostic Factors

2012

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Primary hepatic leiomyosarcoma (LMS) is a rare malignancy of the liver in adults, with variable overall survival (OS). The main purpose of this study was to identify prognostic factors of improved survival. Relevant data were abstracted from MEDLINE, EMBASE, and Academic Search Premiere (ASP), and from the medical records of a patient treated at our institution. Multivariate analysis was conducted by generating Cox proportional hazard ratios. We identified 109 patients with primary hepatic LMS; 95 were included for basic description, and 84 for OS analysis. Median age was 58 years (range 19–86 years), 45.0% of the patients were female, and 21.1% were AJCC stage IV. The primary treatment for all 95 patients was as follows: 61.1% had surgery, 13.7% had chemotherapy, 5.3% had liver transplantation, 2.1% received radiotherapy, and 14.7% were managed conservatively. Median OS was 19 months (range 0–181 months) with 1-, 2-, and 5-year survival rates of 61.2, 41.1, and 14.5%, respectively. In a multivariate analysis, smaller size of the largest hepatic lesion (p = 0.038) and negative resection margin (p = 0.0004) were associated with improved survival. Complete surgical resection with clear margin is necessary to improve survival of patients with primary hepatic LMS.

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Primary Leiomyosarcoma of the Liver

Cited by 24 publications

References 4 publications

Epstein-Barr Virus-associated Smooth Muscle Tumors in AIDS Patients: A Largest Case (Series)

Epstein-Barr Virus-associated Smooth Muscle Tumors in AIDS Patients: A Largest Case (Series)

Epstein-Barr Virus Infection-Associated Smooth-Muscle Tumors in Patients with AIDS

Primary Hepatic Leiomyosarcoma in Adults: Analysis of Prognostic Factors

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