Primary Leiomyosarcoma in the Heart of a Guinea Pig

Vogler, Barbara Renate; Vetsch, E.; Wernick, Morena B.; Sydler, Titus; Wiederkehr, D.

doi:10.1016/j.jcpa.2012.04.005

Cited by 6 publications

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“…The primary leiomyosarcoma was noticed e.g. in the heart of a three-year-old female guinea pig (Vogler et al 2012), however, to our knowledge there is no report of ovarian leiomyosarcoma in this animal species. In women, the most common manifestation of leiomyomas is uterine and these neoplasms are called fibroids; ovarian leiomyosarcomas belong to highly aggressive tumours with hormonal influence (Fletcher et al 2002;Divya and Srinivasamurthy 2014).…”

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confidence: 72%

Leiomyosarcoma of the ovary in a young female guinea pig – a case report

2017

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This case report presents a one-year old pet female smooth-coated guinea pig with a diagnosis of leiomyosarcoma of the left ovary with locally aggressive behaviour. The animal had been showing lethargy and alopetic dermatosis for a few weeks. The mass in the area of the left ovary was suspected based on palpation, x-ray, ultrasonography of the abdominal cavity and the presence of the mass in the abdomen was confirmed by probatory laparotomy. Since the lesion was inoperable due to its size and infiltrative growth, the animal was euthanized. Leiomyosarcoma of the ovary with infiltrative growth into spleen and pancreas was diagnosed based on histopathological examination and the diagnosis was proved by immunohistochemical staining for the presence of smooth muscle actin. This is the first described case of this type of tumour in young intact female guinea pig. The case report could contribute to better understanding and knowledge of the occurrence of neoplastic changes of the ovary in guinea pigs especially for better treatment management and prevention of reproductive tract diseases.

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confidence: 72%

Leiomyosarcoma of the ovary in a young female guinea pig – a case report

2017

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“…31 Primary leiomyosarcoma originating from smooth muscle within striated muscle bundles and not from the striated muscle itself is extremely rare. 6,32 In the veterinary literature, there are only a few reports of primary leiomyosarcoma in the skeletal muscles, including leiomyosarcoma in the hind limb of a hamster with metastasis to the bone marrow, lungs, and diaphragm, 33 and leiomyosarcoma in the hind leg of a Taiwanese macaque (Macaca cyclopis). 29 Leiomyosarcomas localized in the soft tissues such as skeletal muscle are thought to originate from smooth muscle of small blood vessels.…”

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confidence: 99%